{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T09:00:22Z","timestamp":1780736422607,"version":"3.54.1"},"reference-count":14,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FOC"],"published-print":{"date-parts":[[1998,10]]},"abstract":"<jats:p>The authors retrospectively evaluated the short-term neurological improvement of 69 patients undergoing endovascular treatment for symptomatic cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH). The patient group observed here is a subset of patients enrolled in the multicenter North American Trial of Tirilazad in SAH. Thirty-one patients were treated with intraarterial administration of papaverine (IAP). Fourteen patients were only treated with transluminal balloon angioplasty (TBA), and 24 patients received a combination of angioplasty and papaverine.<\/jats:p>\n                  <jats:p>The purpose of this study was to compare the effects of IAP and TBA on short-term clinical improvement of patients. Daily clinical staging with the modified Glasgow Coma Scale and every-other-day transcranial Doppler (TCD) measurements allowed for a close investigation of the clinical course. Furthermore, this study was designed to investigate the effects of treatment timing on short-term outcome.<\/jats:p>\n                  <jats:p>Although TCD studies demonstrated a decrease in flow velocities in the middle cerebral artery in both treatment groups, indicating a vasodilating effect of both treatment modalities (dv = -18.4 cm\/second for papaverine, dv = -26.04 cm\/second for angioplasty; p = 0.5509), there was no significant difference in clinical improvement at Days 1 and 4 postprocedure (p = 0.1996). Neither of the two treatment forms showed an effect of therapy timing on neurological outcome.<\/jats:p>\n                  <jats:p>Neither IAP nor TBA was correlated with a high percentage of short-term neurological improvement. The authors discuss reasons why those procedures may result in limited clinical change.<\/jats:p>","DOI":"10.3171\/foc.1998.5.4.9","type":"journal-article","created":{"date-parts":[[2008,1,24]],"date-time":"2008-01-24T06:48:40Z","timestamp":1201157320000},"page":"E8","source":"Crossref","is-referenced-by-count":11,"title":["Endovascular treatment for symptomatic cerebral vasospasm after subarachnoid hemorrhage: transluminal balloon angioplasty compared with intraarterial papaverine"],"prefix":"10.3171","volume":"5","author":[{"given":"Volker A.","family":"Coenen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn Apperson","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Mstat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal F.","family":"Kassell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard S.","family":"Polin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"p_4","first-page":"27","volume":"16","year":"1995","journal-title":"AJNR"},{"key":"p_8","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1998.88.2.0277"},{"key":"p_15","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1161\/01.STR.23.2.205","volume":"23","author":"Surgery","year":"1992","journal-title":"Stroke"},{"key":"p_18","first-page":"361","author":"Amsterdam","year":"1993","journal-title":"Elsevier"},{"key":"p_20","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1992.77.6.0848"},{"key":"p_23","first-page":"337","author":"Amsterdam","year":"1993","journal-title":"Elsevier"},{"key":"p_30","first-page":"329","author":"Findlay","year":"1993","journal-title":"Elsevier"},{"key":"p_32","first-page":"348","volume":"39","year":"1992","journal-title":"Neurosurg"},{"key":"p_34","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1989.71.5.0654"},{"key":"p_36","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199806000-00031"},{"key":"p_41","first-page":"365","author":"Vasospasm","year":"1993","journal-title":"Elsevier"},{"key":"p_42","first-page":"321","author":"Zubkov YN","year":"1993","journal-title":"Cerebral Vasospasm. Amsterdam: Elsevier"},{"key":"p_44","doi-asserted-by":"publisher","DOI":"10.1007\/BF01406044"},{"key":"p_46","first-page":"325","author":"Findlay","year":"1993","journal-title":"Elsevier"}],"container-title":["Neurosurgical Focus"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/neurosurg-focus\/5\/4\/article-pE8.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/neurosurg-focus\/5\/4\/article-pE8.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/neurosurg-focus\/5\/4\/article-pE8.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T08:12:07Z","timestamp":1780733527000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/neurosurg-focus\/5\/4\/article-pE8.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,10]]},"references-count":14,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.3171\/foc.1998.5.4.9","relation":{},"ISSN":["1092-0684"],"issn-type":[{"value":"1092-0684","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,10]]}}}