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Resection risks damaging these critical structures, and radiotherapeutic techniques, similar to those applied for paranasal sinus tumors, may damage these vital structures and result in late sequelae such as blindness and cortical necrosis.<\/jats:p>\n                  <jats:p>Management strategies for this neoplasm lack uniformity, and there is no universally accepted staging system. In this paper the authors discuss the clinical presentation, radiological and pathological features, and treatment of this rare, malignant skull base neoplasm, as well as review the literature. They also present their results and treatment regimen, which includes preoperative radio- and chemotherapy or 1) craniofacial resection if the lesion has a significant intrac-erebral component, or 2) frontal sinus resection if little intracranial extension exists.<\/jats:p>","DOI":"10.3171\/foc.2002.12.5.5","type":"journal-article","created":{"date-parts":[[2008,1,24]],"date-time":"2008-01-24T06:58:03Z","timestamp":1201157883000},"page":"1-9","source":"Crossref","is-referenced-by-count":39,"title":["Esthesioneuroblastoma: clinical presentation, radiological, and pathological features, treatment, review of the literature, and the University of Virginia experience"],"prefix":"10.3171","volume":"12","author":[{"given":"Rod J.","family":"Oskouian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Jane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron S.","family":"Dumont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas M.","family":"Sheehan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey J.","family":"Laurent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Levine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"p_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1001\/archotol.1975.00780300005001","volume":"101","author":"Bailey BJ","year":"1975","journal-title":"Arch Otolaryngol"},{"key":"p_2","first-page":"404","volume":"15","author":"Berger L","year":"1926","journal-title":"Bull Assoc Fr Etude Cancer"},{"key":"p_3","first-page":"410","volume":"13","author":"Berger L","year":"1924","journal-title":"Bull Assoc Fr Etude Cancer"},{"key":"p_4","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1001\/archotol.1997.01900010038005","volume":"123","author":"Bhattacharyya N","year":"1997","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"p_5","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199011000-00013"},{"key":"p_6","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(05)80068-1"},{"key":"p_7","first-page":"2683","volume":"17","author":"Broich G","year":"1997","journal-title":"Anticancer Res"},{"key":"p_8","doi-asserted-by":"publisher","DOI":"10.1007\/BF01054767"},{"key":"p_9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1977.tb01611.x"},{"key":"p_10","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(86)90368-2"},{"key":"p_11","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880140610"},{"key":"p_12","first-page":"658","volume":"9","author":"Devaney K","year":"1996","journal-title":"Mod Pathol"},{"key":"p_13","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0039-6109(16)41285-5","volume":"57","author":"Djalilian M","year":"1977","journal-title":"Surg Clin North Am"},{"key":"p_14","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.46.1.83"},{"key":"p_15","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199208000-00001"},{"key":"p_16","first-page":"825","author":"Ebersold MJ","year":"1995","journal-title":"Brian Tumors: An Encyclopedic Approach. 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