{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T14:56:54Z","timestamp":1789916214276,"version":"4.0.1"},"reference-count":19,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2007,7]]},"abstract":"\n Object<\/jats:title>\n The authors prospectively assessed the value of awake craniotomy used nonselectively in patients undergoing resection of supratentorial tumors.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n The demographic features, presenting symptoms, tumor location, histological diagnosis, outcomes, and complications were documented for 610 patients who underwent awake craniotomy for supratentorial tumor resection. Intraoperative brain mapping was used in 511 cases (83.8%). Mapping identified eloquent cortex in 115 patients (22.5%) and no eloquent cortex in 396 patients (77.5%).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Neurological deficits occurred in 89 patients (14.6%). In the subset of 511 patients in whom brain mapping was performed, 78 (15.3%) experienced postoperative neurological worsening. This phenomenon was more common in patients with preoperative neurological deficits or in those individuals in whom mapping successfully identified eloquent tissue. Twenty-five (4.9%) of the 511 patients suffered intraoperative seizures, and two of these individuals required intubation and induction of general anesthesia after generalized seizures occurred.<\/jats:p>\n Four (0.7%) of the 610 patients developed wound complications. Postoperative hematomas developed in seven patients (1.1%), four of whom urgently required a repeated craniotomy to allow evacuation of the clot. Two patients (0.3%) required readmission to the hospital soon after being discharged. There were three deaths (0.5%).<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Awake craniotomy is safe, practical, and effective during resection of supratentorial lesions of diverse pathological range and location. It allows for intraoperative brain mapping that helps identify and protect functional cortex. It also avoids the complications inherent in the induction of general anesthesia. Awake craniotomy provides an excellent alternative to surgery of supratentorial brain lesions in patients in whom general anesthesia has been induced.<\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/jns-07\/07\/0001","type":"journal-article","created":{"date-parts":[[2008,1,24]],"date-time":"2008-01-24T07:54:27Z","timestamp":1201161267000},"page":"1-6","source":"Crossref","is-referenced-by-count":243,"title":["Prospective study of awake craniotomy used routinely and nonselectively for supratentorial tumors"],"prefix":"10.3171","volume":"107","author":[{"given":"Demitre","family":"Serletis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Bernstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-1070001","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1227\/01.neu.0000243290.36910.a2","article-title":"Intraoperative language localization in multilingual patients with gliomas","volume":"59","author":"Bello","year":"2006"},{"key":"b2-1070001","series-title":"Cancer","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1002\/1097-0142(19940915)74:6<1784::AID-CNCR2820740622>3.0.CO;2-D","article-title":"The effect of extent of resection on recurrence in patients with low grade cerebral hemisphere gliomas","volume":"74","author":"Berger","year":"1994"},{"key":"b3-1070001","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1227\/00006123-198911000-00015","article-title":"Brain mapping techniques to maximize resection, safety, and seizure control in children with brain tumors","volume":"25","author":"Berger","year":"1989"},{"key":"b4-1070001","series-title":"Stereotact Funct Neurosurg","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1159\/000098989","article-title":"Intraoperative brain mapping techniques in neuro-oncology","volume":"58","author":"Berger","year":"1992"},{"key":"b5-1070001","series-title":"Neurosurg Clin N Am","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/S1042-3680(18)30824-6","article-title":"Neurophysiological monitoring during astrocytoma surgery","volume":"1","author":"Berger","year":"1990"},{"key":"b6-1070001","series-title":"Can J Neurol Sci","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1017\/S0317167100052781","article-title":"Outpatient craniotomy for brain tumor: a pilot feasibility study in 46 patients","volume":"28","author":"Bernstein","year":"2001"},{"key":"b7-1070001","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"2","DOI":"10.3171\/jns.2004.100.1.0002","article-title":"Surgical innovation or surgical evolution: an ethical and practical guide to handling novel neurosurgical procedures","volume":"100","author":"Bernstein","year":"2004"},{"key":"b8-1070001","series-title":"Anesth Analg","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1097\/00000539-200101000-00018","article-title":"Awake craniotomy for removal of intracranial tumor: considerations for early discharge","volume":"92","author":"Blanshard","year":"2001"},{"key":"b9-1070001","series-title":"J Clin Neurosci","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.jocn.2003.09.003","article-title":"Anaesthesia for awake craniotomy: a modern approach","volume":"11","author":"Costello","year":"2004"},{"key":"b10-1070001","series-title":"Neurosurgery","first-page":"567","article-title":"Cortical localization of temporal lobe language sites in patients with gliomas","volume":"34","author":"Haglund","year":"1994"},{"key":"b11-1070001","series-title":"Anesth Analg","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1213\/01.ANE.0000181287.86811.5C","article-title":"Patient satisfaction with awake craniotomy for tumor surgery: a comparison of remifentanil and fentanyl in conjunction with propofol","volume":"102","author":"Manninen","year":"2006"},{"key":"b12-1070001","series-title":"J Clin Anesth","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/S0952-8180(02)00354-9","article-title":"Postoperative nausea and vomiting after craniotomy for tumor surgery: a comparison between awake craniotomy and general anesthesia","volume":"14","author":"Manninen","year":"2002"},{"key":"b13-1070001","series-title":"Science","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1126\/science.472757","article-title":"Human language cortex: localization of memory, syntax, and sequential motor-phoneme identification systems","volume":"205","author":"Ojemann","year":"1979"},{"key":"b14-1070001","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"316","DOI":"10.3171\/jns.1989.71.3.0316","article-title":"Cortical language localization in left, dominant hemisphere. 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