{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:22:52Z","timestamp":1780636972413,"version":"3.54.1"},"reference-count":6,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p> Surgical manipulation of the fifth cranial nerve during its intra-or extracranial course may lead to bradycardia or even asystole as well as arterial hypotension, a phenomenon described as the trigeminocardiac reflex (TCR). The authors studied the impact of this reflex on postoperative auditory function in patients undergoing vestibular schwannoma (VS) surgery.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p> One hundred patients scheduled for VS surgery were studied prospectively for parameters influencing the postoperative auditory function. The evaluation included sex, age, pre-and postoperative auditory function, preoperative mean arterial blood pressure, preoperative medical diseases or medication (for example, antiarrhythmia drugs), tumor size and localization, and the intraoperative occurrence of the TCR.<\/jats:p>\n<jats:p>The TCR, which occurred in 11% of the patients, influenced the postoperative hearing function in the patients with Hannover Class T3 and T4 VSs.<\/jats:p>\n<jats:p>With an overall hearing preservation of 47%, 11.1% of the patients in the TCR group and 51.4% of those in the non-TCR group experienced preserved hearing function postoperatively. In cases involving larger tumors (Hannover Class T3 and T4), an intraoperative TCR was associated with a significantly worse postoperative hearing function during VS surgery (p = 0.005).<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p> The hypotension following TCR is a negative prognostic factor for hearing preservation in patients undergoing VS surgery. Patients' knowledge of this can be increased pre-and postoperatively. Further study of this phenomenon will advance the understanding of the underlying mechanisms and may help to improve hearing preservation by controlling the occurrence of the TCR.<\/jats:p><\/jats:sec>","DOI":"10.3171\/jns-07\/07\/0243","type":"journal-article","created":{"date-parts":[[2008,1,24]],"date-time":"2008-01-24T12:54:27Z","timestamp":1201179267000},"page":"243","source":"Crossref","is-referenced-by-count":42,"title":["Trigeminocardiac Reflex"],"prefix":"10.3171","volume":"107","author":[{"given":"Bernhard J.","family":"Schaller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-1070243","series-title":"Ann Otol Rhinol Laryngol","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1177\/000348948809700110","article-title":"Hearing preservation in unilateral acoustic neuroma surgery","volume":"97","author":"Gardner","year":"1988"},{"key":"b2-1070243","series-title":"Acta Neurochir (Wien)","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1007\/s00701-006-0894-2","article-title":"Detection and prevention of the trigeminocardiac reflex during cerebellopontine angle surgery","volume":"148","author":"Gharabaghi","year":"2006"},{"key":"b3-1070243","series-title":"J Neurosurg Anesthesiol","first-page":"45","article-title":"Trigemino-cardiac reflex during microvascular trigeminal decompression in cases of trigeminal neuralgia","volume":"17","author":"Schaller","year":"2005"},{"key":"b4-1070243","series-title":"Clin Neurol Neurosurg","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.clineuro.2004.12.004","article-title":"Trigeminocardiac reflex during transsphenoidal surgery for pituitary adenomas","volume":"107","author":"Schaller","year":"2005"},{"key":"b5-1070243","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"215","DOI":"10.3171\/jns.1999.90.2.0215","article-title":"Trigeminocardiac reflex during surgery in the cerebellopontine angle","volume":"90","author":"Schaller","year":"1999"},{"key":"b1-1070243a","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"215","DOI":"10.3171\/jns.1999.90.2.0215","article-title":"Trigeminocardiac reflex during surgery in the cerebellopontine angle","volume":"90","author":"Schaller","year":"1999"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/107\/1\/article-p243.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/107\/1\/article-p243.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/107\/1\/article-p243.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T01:21:39Z","timestamp":1681348899000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/107\/1\/article-p243.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":6,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3171\/jns-07\/07\/0243","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[2007,7]]}}}