{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T00:42:23Z","timestamp":1792888943168,"version":"4.5.0"},"reference-count":39,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>The hyperostosis frequently associated with sphenoid wing meningiomas is actual invasion of bone by the tumor. The intracranial portion of the tumor is usually thin with en plaque spread, and the tumor tends to invade the orbit through the superior orbital fissure.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>The authors reviewed the records of 67 patients with sphenoid wing meningiomas who underwent surgery at the University of Arkansas for Medical Sciences between 1994 and 2004. In all 67 cases, the surgery was performed by the senior author. Seventeen of the patients had the distinguishing characteristics of hyperostotic sphenoid wing meningiomas\u2014extensive bone invasion, en plaque dural involvement, and a minimal intracranial mass with minimal orbital involvement. In all patients, hyperostosis was determined on the basis of preoperative neuroimaging. Histopathological evaluation of bone specimens was performed in 14 cases. Estrogen and progesterone receptor expression and Ki 67 labeling were evaluated in all specimens. Chromosome analysis was performed in all tumors resected since 2001 (seven cases). Particular attention was paid to removing all involved bone and dura mater.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Total removal was achieved in 14 cases (82.3%), with only one recurrence (7.1%) over a mean follow-up period of 36 months (range 5\u201372 months). Radical resection was followed by cranioorbital reconstruction to prevent enophthalmos and to obtain good cosmetic results. No deaths or serious complications occurred in association with surgery. Proptosis was corrected in all cases and visual acuity improved in seven (70%) of 10 cases. Revision of the orbital reconstruction was required because of postoperative enophthalmos (two cases) or restricted postoperative ocular movement (one case).<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Sphenoid wing meningiomas frequently invade bone, although such invasion does not represent malignancy. These lesions are generally histologically benign. Total removal with a prospect for cure and visual preservation should be the goal of treatment. This requires extensive drilling of the invaded bone and extensive excision of the involved dura. When the optic canal is involved, it should be decompressed. Extensive bone resection should be followed by cranioorbital reconstruction for good cosmesis and to prevent enophthalmos.<\/jats:p><\/jats:sec>","DOI":"10.3171\/jns-07\/11\/0905","type":"journal-article","created":{"date-parts":[[2007,12,13]],"date-time":"2007-12-13T18:48:13Z","timestamp":1197571693000},"page":"905-912","source":"Crossref","is-referenced-by-count":128,"title":["Management of bone-invasive, hyperostotic sphenoid wing meningiomas"],"prefix":"10.3171","volume":"107","author":[{"given":"Kerem","family":"Bikmaz","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Mrak","sequence":"additional","affiliation":[{"name":"Neuropathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ossama","family":"Al-Mefty","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-1070905","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"51","DOI":"10.3171\/jns.1983.58.1.0051","article-title":"The recurrence of intracranial meningiomas after surgical treatment","volume":"58","author":"Adegbite","year":"1983"},{"key":"b2-1070905","series-title":"Contemp Neurosurg","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00029679-199214090-00001","article-title":"The cranio-orbital zygomatic approach for intracranial lesions","volume":"14","author":"Al-Mefty","year":"1992"},{"key":"b3-1070905","series-title":"Surg Neurol","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/0090-3019(85)90012-6","article-title":"Superolateral orbital exposure and orbital reconstruction","volume":"23","author":"Al-Mefty","year":"1985"},{"key":"b4-1070905","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"210","DOI":"10.3171\/jns.2004.101.2.0210","article-title":"Malignant progression in meningioma: documentation of a series and analysis of cytogenetic findings","volume":"101","author":"Al-Mefty","year":"2004"},{"key":"b5-1070905","series-title":"Meningiomas and Their Surgical Management","first-page":"311","article-title":"Primary intraorbital meningiomas","author":"Basso","year":"1991"},{"key":"b6-1070905","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"587","DOI":"10.3171\/jns.1980.53.5.0587","article-title":"Invading meningiomas of the sphenoid ridge","volume":"53","author":"Bonnal","year":"1980"},{"key":"b7-1070905","series-title":"Rev Neurol","first-page":"537","article-title":"Deux cas d'henicraniose","volume":"11","author":"Brissaud","year":"1903"},{"key":"b8-1070905","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"188","DOI":"10.3171\/jns.1952.9.2.0188","article-title":"Pterional meningiomas en plaque","volume":"9","author":"Castellano","year":"1952"},{"key":"b9-1070905","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3171\/jns.1984.60.1.0052","article-title":"Morbidity, mortality, and quality of life following surgery for intracranial meningiomas. A retrospective study in 257 cases","volume":"60","author":"Chan","year":"1984"},{"key":"b10-1070905","series-title":"Arch Neurol Psychiatry","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1001\/archneurpsyc.1922.02190140030003","article-title":"The cranial hyperostoses produced by meningeal endotheliomas","volume":"8","author":"Cushing","year":"1922"},{"key":"b11-1070905","series-title":"Meningiomas: Their Classification, Regional Behaviour, Life History, and Surgical End Results","author":"Cushing","year":"1938"},{"key":"b12-1070905","series-title":"Clin Neurosurg","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1093\/neurosurgery\/25.CN_suppl_1.435","article-title":"Bone problems in meningiomas invading the base of the skull","volume":"25","author":"Derome","year":"1978"},{"key":"b13-1070905","series-title":"Surg Neurol","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0090-3019(01)00440-2","article-title":"Surgical management of meningioma en plaque of the sphenoid wing","volume":"55","author":"de J\u00e9sus","year":"2001"},{"key":"b14-1070905","series-title":"J Neurosurg Sci","first-page":"151","article-title":"Hyperostosing meningiomas of the cranial vault","volume":"24","author":"De Santis","year":"1980"},{"key":"b15-1070905","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1097\/00006123-199905000-00008","article-title":"Benign nonmeningeal tumors of the cavernous sinus","volume":"44","author":"Eisenberg","year":"1999"},{"key":"b16-1070905","series-title":"Arch Neurol Psychiatry","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1001\/archneurpsyc.1933.02240110003001","article-title":"Meningeal fibroblastomas of the cerebrum","volume":"29","author":"Frazier","year":"1933"},{"key":"b17-1070905","series-title":"J Neuropathol Exp Neurol","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1097\/00005072-194801000-00006","article-title":"Bone formation and destruction in hyperostoses associated with meningiomas","volume":"7","author":"Freedman","year":"1948"},{"key":"b18-1070905","series-title":"Acta Neurol Scand","first-page":"243","article-title":"Localised cranial hyperostosis of meningiomas: a result of neoplastic enzymatic activity?","volume":"87","author":"Heick","year":"1993"},{"key":"b19-1070905","series-title":"Surg Neurol","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/0090-3019(86)90259-4","article-title":"Seemingly complete removal of histologically benign intracranial meningioma: late recurrence rate and factors predicting recurrence in 657 patients. A multivariate analysis","volume":"26","author":"J\u00e4\u00e4skel\u00e4inen","year":"1986"},{"key":"b20-1070905","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"517","DOI":"10.3171\/jns.2004.100.3.0517","article-title":"The anatomical basis for surgical preservation of temporal muscle","volume":"100","author":"Kadri","year":"2004"},{"key":"b21-1070905","series-title":"Neurosurgery","first-page":"2","article-title":"Factors affecting operative and excess long-term mortality in 935 patients with intracranial meningioma","volume":"31","author":"Kallio","year":"1992"},{"key":"b22-1070905","series-title":"AJR Am J Roentgenol","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.2214\/ajr.149.5.1017","article-title":"CT features of hyperostosing meningioma en plaque","volume":"149","author":"Kim","year":"1987"},{"key":"b23-1070905","series-title":"AJR Am J Roentgenol","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.2214\/ajr.141.6.1217","article-title":"The dural lucent sign: characteristic sign of hyperostosing meningioma en plaque","volume":"141","author":"Kim","year":"1983"},{"key":"b24-1070905","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1227\/00006123-198311000-00018","article-title":"Triple fossa metastasis of prostate cancer","volume":"13","author":"Kwee","year":"1983"},{"key":"b25-1070905","series-title":"Eur J Neurol","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1046\/j.1468-1331.1999.630363.x","article-title":"Bilateral sphenoid wing metastases of prostate cancer presenting with extensive brain edema","volume":"6","author":"Lindsberg","year":"1999"},{"key":"b26-1070905","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"114","DOI":"10.3171\/jns.1972.36.1.0114","article-title":"Meningiomas of the sphenoidal ridge","volume":"36","author":"MacCarty","year":"1972"},{"key":"b27-1070905","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"202","DOI":"10.3171\/jns.1994.80.2.0202","article-title":"Recurrent spheno-orbital meningioma","volume":"80","author":"Maroon","year":"1994"},{"key":"b28-1070905","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1097\/00006123-199607000-00002","article-title":"Recurrence of cranial base meningiomas","volume":"39","author":"Mathiesen","year":"1996"},{"key":"b29-1070905","series-title":"Neurosurg Clin N Am","first-page":"193","article-title":"Predicting recurrence of intracranial meningiomas. A multivariate clinicopathologic model\u2014interim report of the New York University Medical Center Meningioma Project","volume":"5","author":"Miller","year":"1994"},{"key":"b30-1070905","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"18","DOI":"10.3171\/jns.1985.62.1.0018","article-title":"Meningioma: analysis of recurrence and progression following neurosurgical resection","volume":"62","author":"Mirimanoff","year":"1985"},{"key":"b31-1070905","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"455","DOI":"10.3171\/jns.1999.90.3.0455","article-title":"Preoperative identification of meningiomas that are highly likely to recur","volume":"90","author":"Nakasu","year":"1999"},{"key":"b32-1070905","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1227\/01.NEU.0000079484.19821.4A","article-title":"Recurrence of olfactory groove meningiomas","volume":"53","author":"Obeid","year":"2003"},{"key":"b33-1070905","series-title":"Radiology","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1148\/123.2.375","article-title":"Prognosis in meningioma through evaluation of skull bone patterns","volume":"123","author":"Olmsted","year":"1977"},{"key":"b34-1070905","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1227\/00006123-197903000-00016","article-title":"Primary intraosseous meningioma presenting as a solitary osteolytic skull lesion: case report","volume":"4","author":"Pearl","year":"1979"},{"key":"b35-1070905","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1097\/00006123-199904000-00028","article-title":"Hyperostosis associated with meningioma of the cranial base: secondary changes or tumor invasion","volume":"44","author":"Pieper","year":"1999"},{"key":"b36-1070905","series-title":"Surg Neurol","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/S0090-3019(82)80006-2","article-title":"Hyperostosing meningiomas of the sphenoid ridge\u2014clinical features, surgical therapy, and long-term observations: review of 49 cases","volume":"17","author":"Pompili","year":"1982"},{"key":"b37-1070905","series-title":"AJR Am J Roentgenol","first-page":"1","article-title":"Roentgenological aspects of brain tumours: meningiomas","volume":"13","author":"Sosman","year":"1925"},{"key":"b38-1070905","series-title":"Arch Neurol Psychiatry","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1001\/archneurpsyc.1929.02210210163011","article-title":"Cranial hyperostosis associated with underlying meningeal fibroblastoma","volume":"21","author":"Spiller","year":"1929"},{"key":"b39-1070905","series-title":"JAMA","first-page":"2059","article-title":"Hemicraniosis and cure of brain tumor by operation","volume":"49","author":"Spiller","year":"1907"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/107\/5\/article-p905.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/107\/5\/article-p905.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/107\/5\/article-p905.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T01:14:57Z","timestamp":1681348497000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/107\/5\/article-p905.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":39,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.3171\/jns-07\/11\/0905","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11]]}}}