{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T03:45:49Z","timestamp":1771645549598,"version":"3.50.1"},"reference-count":15,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1972,1]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Alterations in cerebrovascular tone caused by the intracarotid administration of prostaglandin E<jats:sub>1<\/jats:sub>, A<jats:sub>1<\/jats:sub>, and F<jats:sub>2<jats:italic>a<\/jats:italic><\/jats:sub> were evaluated by means of a standard perfusion technique in dogs and monkeys. Only PGF<jats:sub>2<jats:italic>a<\/jats:italic><\/jats:sub> evoked a selective increase in cerebrovascular tone. This effect was observed in both species and resembled the action of serotonin. On the other hand, prostaglandin E<jats:sub>1<\/jats:sub> selectively reduced cerebrovascular tone in dogs, but had no such specific action in the monkey. Prostaglandin A<jats:sub>1<\/jats:sub> lacked a specific influence on the cerebral circulation of either species. Since different prostaglandins produced specific and diametrically opposite effects on cerebral circulation, these substances may be useful in experimental studies of vasospasm, and may normally influence cerebrovascular tone.<\/jats:p>","DOI":"10.3171\/jns.1972.36.1.0034","type":"journal-article","created":{"date-parts":[[2009,5,7]],"date-time":"2009-05-07T14:47:14Z","timestamp":1241707634000},"page":"34-42","source":"Crossref","is-referenced-by-count":59,"title":["The effects of prostaglandins E1, A1, and F2a on the cerebral circulation of dogs and monkeys"],"prefix":"10.3171","volume":"36","author":[{"given":"Ira C.","family":"Denton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard P.","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James 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