{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T09:29:42Z","timestamp":1749634182278},"reference-count":32,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1975,8]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713Four patients received <jats:sup>3<\/jats:sup>H-thymidine 4 to 7 days and vinblastine 4 to 6 hours prior to operation for recurrent malignant gliomas (three glioblastomas and one anaplastic astrocytoma). Tumor biopsies obtained at operation were fixed for routine histological studies and radioautography. The tumors' growth fractions averaged 0.28 with a range of 0.14 to 0.39. The tumor cell cycle time calculated in three patients had a mean duration of 57 hours with a standard deviation of 6 hours. The authors concluded that: 1) single short-term courses of cell-cycle specific chemotherapeutic agents alone will probably fail to achieve either significant reduction in tumor mass or dramatic clinical improvement; 2) cell-cycle phase-specific drugs should be administered to maintain effective blood levels over 2 to 3 days for maximal tumor cell kill. Tumor growth rate appears to correlate with the fraction of proliferating cells rather than the length of the tumor cell cycle. The scientific basis for combination drug and multimodality therapy is discussed.<\/jats:p>","DOI":"10.3171\/jns.1975.43.2.0127","type":"journal-article","created":{"date-parts":[[2009,5,7]],"date-time":"2009-05-07T15:04:32Z","timestamp":1241708672000},"page":"127-135","source":"Crossref","is-referenced-by-count":81,"title":["Chemotherapeutic implications of growth fraction and cell cycle time in glioblastomas"],"prefix":"10.3171","volume":"43","author":[{"given":"Takao","family":"Hoshino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles B.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark L.","family":"Rosenblum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marvin","family":"Barker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Cancer Res","first-page":"910","article-title":"A study on the establishment and growth of tumor metastases with tritiated thymidine.","volume":"20","author":"Baserga","year":"1960"},{"key":"b2","series-title":"Can J Physiol Pharmacol","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1139\/y64-045","article-title":"A preliminary investigation of the fate of tritiated vinblastine in rats.","volume":"42","author":"Beer","year":"1964"},{"key":"b3","series-title":"Lab Invest","first-page":"510","article-title":"Duration of mitosis and related time parameters of erythroblasts.","volume":"15","author":"Berman","year":"1966"},{"key":"b4","series-title":"Radiation Therapy of Tumors and Diseases of the Nervous System.","author":"Bourchard","year":"1966"},{"key":"b5","series-title":"Brain Nerve (Tokyo)","first-page":"767","article-title":"(Studies on the DNA synthesis function of glial cells by means of 3H-thymidine microradioautography).","volume":"15","author":"Chigasaki","year":"1963"},{"key":"b6","series-title":"Exp Cell Res","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/0014-4827(65)90074-1","article-title":"The relationship between the duration of the S phase and the fraction of cells which incorporate 3H-thymidine during exponential growth.","volume":"39","author":"Cleaver","year":"1965"},{"key":"b7","series-title":"Thymidine Metabolism and Cell Kinetics.","author":"Cleaver","year":"1967"},{"key":"b8","series-title":"Modern Radiotherapy and Oncology: Central Nervous System Tumours.","first-page":"131","article-title":"Localized treatments to the brain","author":"Deeley","year":"1974"},{"key":"b9","series-title":"Cancer Res","first-page":"2593","article-title":"Combination cancer therapy: Presidential address.","volume":"32","author":"Frei","year":"1972"},{"key":"b10","series-title":"Cancer Res","first-page":"1918","article-title":"The stathmokinetic effect of vincristine.","volume":"24","author":"Frei","year":"1964"},{"key":"b11","series-title":"Brain Nerve (Tokyo)","first-page":"1029","article-title":"(Autoradiographic studies of brain tumors using local labeling with 3H-thymidine in vivo.)","volume":"21","author":"Fukuma","year":"1969"},{"key":"b12","series-title":"The Cell Cycle and Cancer.","first-page":"99","article-title":"Cell cycle of cancer cells in man","author":"Gavasto","year":"1971"},{"key":"b13","series-title":"J Nat Cancer Inst","first-page":"519","article-title":"Cell kinetic analysis of a human melanoma in vitro and in vivo.","volume":"47","author":"Hagemann","year":"1971"},{"key":"b14","series-title":"Neurol Med Chir (Tokyo)","doi-asserted-by":"publisher","first-page":"125","DOI":"10.2176\/nmc.11.125","article-title":"Glioma: Its biology in vivo and in vitro.","volume":"11","author":"Hoshino","year":"1971"},{"key":"b15","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"15","DOI":"10.3171\/jns.1972.37.1.0015","article-title":"Cell kinetics of human gliomas.","volume":"37","author":"Hoshino","year":"1972"},{"key":"b16","series-title":"Eur J Cancer","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/0014-2964(67)90023-0","article-title":"Kinetics of cellular proliferation and cell loss in human carcinomas. 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