{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:42:14Z","timestamp":1791657734250,"version":"4.3.4"},"reference-count":7,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1975,8]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 The authors present the case of a 21-year-old woman with primary amenorrhea and hydrocephalus internus, and suggest that the amenorrhea was probably caused by insufficient basal and cyclic activity of luteinizing hormone\/releasing hormone-producing neurons in the hypothalamus. The amenorrhea persisted after ventriculocisternotomy; only after several therapeutic trials with estrogens and progesteron did spontaneous menstrual periods appear more than 5 years after operation.<\/jats:p>","DOI":"10.3171\/jns.1975.43.2.0239","type":"journal-article","created":{"date-parts":[[2009,5,7]],"date-time":"2009-05-07T15:04:32Z","timestamp":1241708672000},"page":"239-243","source":"Crossref","is-referenced-by-count":16,"title":["Deficiency of gonadotropin-releasing factor in a patient with hydrocephalus internus"],"prefix":"10.3171","volume":"43","author":[{"given":"Joseph M.","family":"Coenegracht","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan P. A. M.de","family":"Bie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis N. M.","family":"Coene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Padberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Br Med J","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1136\/bmj.3.5821.267","article-title":"Hormonal responses to synthetic luteinizing hormone and follicle stimulating hormone-releasing hormone in man.","volume":"3","author":"Besser","year":"1972"},{"key":"b2","series-title":"The Abnormal Pneumoencephalogram.","first-page":"388","author":"Davidoff","year":"1955"},{"key":"b3","series-title":"Sem Hop Paris","first-page":"876","article-title":"Syndromes neuroendocriniens et hydropsies ventriculaires ou cisternales.","volume":"27","author":"Guillaume","year":"1951"},{"key":"b4","series-title":"Am J Obstet Gynecol","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/0002-9378(72)90620-5","article-title":"The hypothalamus and reproduction.","volume":"114","author":"Schally","year":"1972"},{"key":"b5","series-title":"Arch Neurol Psychiatry","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1001\/archneurpsyc.1930.02220120088005","article-title":"Occlusion of the aqueduct of Sylvius.","volume":"23","author":"Sheldon","year":"1930"},{"key":"b6","series-title":"J Clin Endocrinol Metab","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1210\/jcem-37-3-491","article-title":"Augmented gonadotropin response to synthetic LRF in hypogonadal state.","volume":"37","author":"Siler","year":"1973"},{"key":"b7","series-title":"J Clin Endocrinol Metab","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1210\/jcem-35-6-931","article-title":"Variation of pituitary responsiveness to synthetic LRF during different phases of the menstrual cycle.","volume":"35","author":"Yen","year":"1972"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/43\/2\/article-p239.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/43\/2\/article-p239.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/43\/2\/article-p239.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T07:29:54Z","timestamp":1658734194000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/43\/2\/article-p239.xml"}},"subtitle":["Case report"],"short-title":[],"issued":{"date-parts":[[1975,8]]},"references-count":7,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3171\/jns.1975.43.2.0239","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[1975,8]]}}}