{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T21:07:35Z","timestamp":1784063255206,"version":"3.55.0"},"reference-count":41,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1976,2]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 The authors measured regional cerebral <jats:sup>133<\/jats:sup>xenon (<jats:sup>133<\/jats:sup>Xe) blood flow (rCBF), intraventricular pressure (IVP), cerebrospinal fluid (CSF) pH and lactate, systemic arterial blood pressure (SAP), and arterial blood gases during the acute phase in 23 comatose patients with severe head injuries. The IVP was kept below 45 mm Hg. The rCBF was measured repeatedly, and the response to induced hypertension and hyperventilation was tested. Most patients had reduced rCBF. No correlation was found between average CBF and clinical condition, and neither global nor regional ischemia contributed significantly to the reduced brain function. No correlation was found between CBF and IVP or CBF and cerebral perfusion pressure (CPP). The CSF lactate was elevated significantly in patients with brain-stem lesions, but not in patients with \u201cpure\u201d cortical lesions. The <jats:sup>133<\/jats:sup>Xe clearance curves from areas of severe cortical lesions had very fast initial components called tissue peaks. The tissue peak areas correlated with areas of early veins in the angiograms, indicating a state of relative hyperemia, referred to as tissue-peak hyperemia. Tissue-peak hyperemia was found in all patients with cortical laceration or severe contusion but not in patients with brainstem lesions without such cortical lesions. The peaks increased in number during clinical deterioration and disappeared during improvement. They could be provoked by induced hypertension and disappeared during hyperventilation. The changes in the tissue-peak areas appeared to be related to the clinical course of the cortical lesion.<\/jats:p>","DOI":"10.3171\/jns.1976.44.2.0191","type":"journal-article","created":{"date-parts":[[2009,5,7]],"date-time":"2009-05-07T15:12:58Z","timestamp":1241709178000},"page":"191-214","source":"Crossref","is-referenced-by-count":142,"title":["Dynamic changes in regional CBF, intraventricular pressure, CSF pH and lactate levels during the acute phase of head injury"],"prefix":"10.3171","volume":"44","author":[{"given":"Erna M.","family":"Enevoldsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Cold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finn","family":"Taageh\u00f8j Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Malmros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1161\/01.STR.2.1.1","article-title":"Cerebral blood flow measurement as a safeguard during carotid endarterectomy.","volume":"2","author":"Boysen","year":"1971"},{"key":"b2","series-title":"J Neurol Neurosurg Psychiatry","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1136\/jnnp.37.4.384","article-title":"Cerebral blood flow and oxygen uptake, and cerebrospinal fluid biochemistry in severe coma.","volume":"37","author":"Brodersen","year":"1974"},{"key":"b3","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"131","DOI":"10.3171\/jns.1973.38.2.0131","article-title":"Regional cerebral blood flow, intracranial pressure, and brain metabolism in comatose patients.","volume":"38","author":"Bruce","year":"1973"},{"key":"b4","series-title":"Am J Pathol","first-page":"455","article-title":"Cerebral ischemia. 3. 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