{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T07:25:46Z","timestamp":1769498746296,"version":"3.49.0"},"reference-count":8,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1976,5]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 <jats:italic>In vitro<\/jats:italic> experiments were performed with a small volume chamber to determine the contractile activity of various vasoactive agents on human basilar and anterior cerebral arteries. Cumulative log-dose response curves were obtained for most of the agents tested including serotonin and three different prostaglandins; many of these curves were found to be similar to curves previously obtained with canine cerebral arteries. It was concluded from these similarities that canine cerebral arteries are a good <jats:italic>in vitro<\/jats:italic> model for studying human cerebral arterial spasm. It was also demonstrated that human cerebrospinal fluid, collected up to 17 days after a subarachnoid hemorrhage from patients with clinical and angiographic evidence of cerebral arterial spasm, would cause large, dose-dependent contractions in human anterior cerebral arteries.<\/jats:p>","DOI":"10.3171\/jns.1976.44.5.0594","type":"journal-article","created":{"date-parts":[[2009,5,7]],"date-time":"2009-05-07T15:12:22Z","timestamp":1241709142000},"page":"594-600","source":"Crossref","is-referenced-by-count":73,"title":["Cerebral arterial spasm"],"prefix":"10.3171","volume":"44","author":[{"given":"George S.","family":"Allen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol J.","family":"Gross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyle A.","family":"French","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelley N.","family":"Chou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"451","DOI":"10.3171\/jns.1974.40.4.0451","article-title":"Cerebral arterial spasm. Part 3: In vivo intracisternal production of spasm by serotonin and blood and its reversal by phenoxybenzamine.","volume":"40","author":"Allen","year":"1974"},{"key":"b2","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"433","DOI":"10.3171\/jns.1974.40.4.0433","article-title":"Cerebral arterial spasm. Part 1: In vitro contractile activity of vasoactive agents on canine basilar and middle cerebral arteries.","volume":"40","author":"Allen","year":"1974"},{"key":"b3","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"442","DOI":"10.3171\/jns.1974.40.4.0442","article-title":"Cerebral arterial spasm. Part 2: In vitro contractile activity of serotonin in human serum and CSF on the canine basilar artery, and its blockade by methylsergide and phenoxybenzamine.","volume":"40","author":"Allen","year":"1974"},{"key":"b4","series-title":"Am J Physiol","doi-asserted-by":"publisher","first-page":"1698","DOI":"10.1152\/ajplegacy.1970.219.6.1698","article-title":"Differential effects of substrate depletion on drug-induced contractions of rabbit aorta.","volume":"219","author":"Altura","year":"1970"},{"key":"b5","series-title":"Am J Physiol","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1152\/ajplegacy.1972.222.2.345","article-title":"Effects of vasoactive agents on isolated human umbilical arteries and veins.","volume":"222","author":"Altura","year":"1972"},{"key":"b6","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"293","DOI":"10.3171\/jns.1974.41.3.0293","article-title":"Role of prostaglandin F2\u03b1 in human cerebral vasospasm.","volume":"41","author":"La Torre","year":"1974"},{"key":"b7","series-title":"Biochemistry of Blood Platelets","first-page":"105","article-title":"Studies on release of biogenic amines from blood platelets","author":"Markwardt","year":"1967"},{"key":"b8","series-title":"Circ Res","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1161\/01.RES.33.1.98","article-title":"Responsiveness of isolated cerebral and peripheral arteries to serotonin, norepinephrine, and transmural electrical stimulation.","volume":"33","author":"Toda","year":"1973"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/44\/5\/article-p594.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/44\/5\/article-p594.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/44\/5\/article-p594.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T08:06:34Z","timestamp":1658736394000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/44\/5\/article-p594.xml"}},"subtitle":["Part 5: In vitro contractile activity of vasoactive agents including human CSF on human basilar and anterior cerebral arteries"],"short-title":[],"issued":{"date-parts":[[1976,5]]},"references-count":8,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.3171\/jns.1976.44.5.0594","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[1976,5]]}}}