{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T16:33:29Z","timestamp":1751387609282},"reference-count":30,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1976,10]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 A choroid plexus papilloma (CPP) removed from a child with communicating hydrocephalus was studied with the electron microscope. In addition to the usual organelles, the neoplastic epithelial cells contained polypoid microvilli, cilia, coated pinocytotic vesicles, and apical tight junctions. The basal surfaces were consistently juxtaposed to large capillaries lined by fenestrated endothelium. The fine structural details of the tumor were essentially the same as those of normal CP and thus appeared ideally suited for an active secretory function. Two additional features in this tumor were tubular bodies in the endothelium and well developed pericytes. The present findings provide strong evidence for cerebrospinal fluid production by CPP, a phenomenon that has long been suggested by clinical observation.<\/jats:p>","DOI":"10.3171\/jns.1976.45.4.0409","type":"journal-article","created":{"date-parts":[[2009,5,7]],"date-time":"2009-05-07T15:10:05Z","timestamp":1241709005000},"page":"409-415","source":"Crossref","is-referenced-by-count":37,"title":["Ultrastructural evidence for CSF production by a choroid plexus papilloma"],"prefix":"10.3171","volume":"45","author":[{"given":"Nitya R.","family":"Ghatak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joe M.","family":"McWhorter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Histochem Cytochem","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1177\/15.3.160","article-title":"Fine structure observations of the uptake of intravenously injected peroxidase by the rat choroid plexus.","volume":"15","author":"Becker","year":"1967"},{"key":"b2","series-title":"Prog Brain Res","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/S0079-6123(08)64147-3","article-title":"The intracerebral movement of proteins injected into blood and cerebrospinal fluid of mice.","volume":"29","author":"Brightman","year":"1968"},{"key":"b3","series-title":"J Cell Biol","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1083\/jcb.40.3.648","article-title":"Junctions between intimately apposed cell membranes in the vertebrate brain.","volume":"40","author":"Brightman","year":"1969"},{"key":"b4","series-title":"Lab Invest","first-page":"376","article-title":"The reaction of pericytes of the central nervous system to exogenous protein.","volume":"26","author":"Cancilla","year":"1972"},{"key":"b5","series-title":"Acta Neuropathol","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1007\/BF00686764","article-title":"A histochemical and fine structure study of the developing rat choroid plexus.","volume":"6","author":"Cancilla","year":"1966"},{"key":"b6","series-title":"Cancer","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1002\/1097-0142(197210)30:4<1130::AID-CNCR2820300434>3.0.CO;2-K","article-title":"Ultrastructure of three choroid plexus papillomas.","volume":"30","author":"Carter","year":"1972"},{"key":"b7","series-title":"Physiology of the Cerebrospinal Fluid.","first-page":"432","author":"Davson","year":"1967"},{"key":"b8","series-title":"Acta Neurol Lat Am","first-page":"99","article-title":"Secretion and drainage of the cerebrospinal fluid.","volume":"1","author":"Davson","year":"1971"},{"key":"b9","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"56","DOI":"10.3171\/jns.1971.34.1.0056","article-title":"The choroid plexus in experimental hydrocephalus. 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