{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T04:41:21Z","timestamp":1768452081753,"version":"3.49.0"},"reference-count":10,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1976,12]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 There has been little comment on the specific management of intracerebral bleeding occurring in patients suffering idiopathic thrombocytopenic purpura. The authors present the cases of four children with intracerebral hemorrhage due to this coagulation disturbance. A plan of management is described based on this experience; it includes immediate control of cerebral edema, emergency splenectomy, supportive care with platelet transfusions and corticosteroids, cerebral angiography, and a definitive neurosurgical procedure. If necessary, the radiological investigation and surgical therapy can be performed with a single general anesthetic. Three of the patients have survived without major neurological sequelae.<\/jats:p>","DOI":"10.3171\/jns.1976.45.6.0700","type":"journal-article","created":{"date-parts":[[2009,5,7]],"date-time":"2009-05-07T15:09:10Z","timestamp":1241708950000},"page":"700-704","source":"Crossref","is-referenced-by-count":17,"title":["Management of intracerebral hemorrhage in idiopathic thrombocytopenic purpura"],"prefix":"10.3171","volume":"45","author":[{"given":"Robin P.","family":"Humphreys","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony D.","family":"Hockley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melvin H.","family":"Freedman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. Fred.","family":"Saunders","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Can Med Assoc J","first-page":"562","article-title":"Idiopathic thrombocytopenic purpura in childhood.","volume":"97","author":"Choi","year":"1967"},{"key":"b2","series-title":"Ann Intern Med","doi-asserted-by":"publisher","first-page":"861","DOI":"10.7326\/0003-4819-53-5-861","article-title":"Idiopathic and secondary thrombocytopenic purpura: clinical study and evaluation of 381 cases over a period of 28 years.","volume":"53","author":"Doan","year":"1960"},{"key":"b3","series-title":"Br J Haematol","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1111\/j.1365-2141.1970.tb01605.x","article-title":"Thrombokinetics in idiopathic thrombocytopenic purpura.","volume":"19","author":"Harker","year":"1970"},{"key":"b4","series-title":"Arch Intern Med","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1001\/archinte.1951.03810120002001","article-title":"\u201cIdiopathic\u201d thrombocytopenia. Review of 89 cases with particular reference to the differentiation and treatment of acute (self-limited) and chronic types.","volume":"88","author":"Hirsch","year":"1951"},{"key":"b5","series-title":"Can Med Assoc J","first-page":"774","article-title":"Cerebrovascular disease in children.","volume":"107","author":"Humphreys","year":"1972"},{"key":"b6","series-title":"Arch Dis Child","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1136\/adc.29.148.502","article-title":"Prognosis in idiopathic thrombocytopenic purpura of childhood.","volume":"29","author":"Kowrower","year":"1954"},{"key":"b7","series-title":"J Pediatr","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/S0022-3476(66)80218-4","article-title":"Idiopathic thrombocytopenic purpura in childhood.","volume":"68","author":"Lusher","year":"1966"},{"key":"b8","series-title":"Pediatrics","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1542\/peds.55.1.68","article-title":"Idiopathic thrombocytopenic purpura in children: diagnosis and management.","volume":"55","author":"McClure","year":"1975"},{"key":"b9","series-title":"Pediatrics","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1542\/peds.33.6.979","article-title":"Diagnosis and treatment: management of idiopathic thrombocytopenic purpura.","volume":"33","author":"Schulman","year":"1964"},{"key":"b10","series-title":"Trans Assoc Am Physicians","first-page":"374","article-title":"The role of the reticuloendothelial system in the pathogenesis of idiopathic thrombocytopenic purpura.","volume":"78","author":"Shulman","year":"1965"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/45\/6\/article-p700.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/45\/6\/article-p700.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/45\/6\/article-p700.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T05:32:12Z","timestamp":1658727132000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/45\/6\/article-p700.xml"}},"subtitle":["Report of four cases"],"short-title":[],"issued":{"date-parts":[[1976,12]]},"references-count":10,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.3171\/jns.1976.45.6.0700","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[1976,12]]}}}