{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:27:41Z","timestamp":1792168061745,"version":"4.4.0"},"reference-count":7,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1977,7]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 A case is reported in which a human chorionic gonadotropin (HCG)-producing ectopic pinealoma was found in a 5-year-old girl with precocious puberty. Physical examination revealed abnormal breast enlargement. Endocrinological study disclosed a high plasma HCG concentration of 1192 ng\/ml with a normal follicular stimulating hormone (FSH) level. The HCG content of the tumor was as high as 400 ng\/mg of acetone dried tissue, but no FSH was detectable. This is the first reported case of precocious puberty associated with pineal tumor in a female.<\/jats:p>","DOI":"10.3171\/jns.1977.47.1.0101","type":"journal-article","created":{"date-parts":[[2009,5,7]],"date-time":"2009-05-07T15:20:22Z","timestamp":1241709622000},"page":"101-105","source":"Crossref","is-referenced-by-count":36,"title":["Human chorionic gonadotropin produced by ectopic pinealoma in a girl with precocious puberty"],"prefix":"10.3171","volume":"47","author":[{"given":"Osami","family":"Kubo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Yamasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Kamijo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Amano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiko","family":"Demura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Clin Endocrinol","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1210\/jcem-29-11-1504","article-title":"Follicle-stimulating activity of human chorionic gonadotropin.","volume":"29","author":"Albert","year":"1969"},{"key":"b2","series-title":"Verh Dtsch Ges Pathol","first-page":"58","article-title":"Teratom und Chorioepitheliom der Zirbel.","volume":"10","author":"Askanazy","year":"1906"},{"key":"b3","series-title":"Biochem J","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1042\/bj1000754","article-title":"Separation and partial purification of the protein hormones from human pituitary glands.","volume":"100","author":"Hartree","year":"1966"},{"key":"b4","series-title":"Jap J Clin Med","first-page":"385","article-title":"Pubertas praecox.","volume":"20","author":"Kageyama","year":"1962"},{"key":"b5","series-title":"Neurol Surg","first-page":"243","article-title":"[Malignant suprasellar teratoma in a girl with elevated serum gonadotropin. Case report and some considerations for development and precocious puberty.]","volume":"2","author":"Mori","year":"1974"},{"key":"b6","series-title":"Saishin Agaku","first-page":"1866","article-title":"[Gonadotropin producing pinealoma.]","volume":"28","author":"Takakura","year":"1973"},{"key":"b7","series-title":"The Diagnosis and Treatment of Endocrine Disorders in Childhood and Adolescence","first-page":"206","author":"Wilkins","year":"1965"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/47\/1\/article-p101.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/47\/1\/article-p101.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/47\/1\/article-p101.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T13:26:31Z","timestamp":1666531591000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/47\/1\/article-p101.xml"}},"subtitle":["Case report"],"short-title":[],"issued":{"date-parts":[[1977,7]]},"references-count":7,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3171\/jns.1977.47.1.0101","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[1977,7]]}}}