{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T08:32:17Z","timestamp":1710491537416},"reference-count":10,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1977,11]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Hypophysectomy was performed in six patients with advanced carcinoma other than from breast and prostate gland to alleviate pain. Two patients received significant and lasting relief of pain; one achieved relief but died from progression of disease 5 weeks after surgery; one patient, initially relieved, had recurrence of pain 3 months later; one had about 50% relief; and one received no benefit. Possible mechanisms for pain relief include changes in pituitary hormones, prostaglandins, and the newly isolated brain peptides, alpha and beta endorphin. These preliminary observations will require further critical evaluation in a larger series to determine the effectiveness of hypophysectomy in relieving pain in cancer other than from the breast and prostate. The results, nevertheless, do imply that a different approach to pain, namely endocrine manipulation, may be beneficial in certain cancer patients.<\/jats:p>","DOI":"10.3171\/jns.1977.47.5.0659","type":"journal-article","created":{"date-parts":[[2009,5,7]],"date-time":"2009-05-07T15:15:37Z","timestamp":1241709337000},"page":"659-662","source":"Crossref","is-referenced-by-count":10,"title":["Pain relief in metastatic cancer other than breast and prostate gland following transsphenoidal hypophysectomy"],"prefix":"10.3171","volume":"47","author":[{"given":"George T.","family":"Tindall","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel W.","family":"Nixon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James H.","family":"Christy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jimmy D.","family":"Neill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Science","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1126\/science.959823","article-title":"Opioid peptides endorphins in pituitary and brain.","volume":"193","author":"Goldstein","year":"1976"},{"key":"b2","series-title":"Proc Natl Acad Sci USA","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1073\/pnas.68.8.1742","article-title":"Stereospecific and nonspecific interactions of the morphine congener levorphanol in subcellular fractions of mouse brain.","volume":"68","author":"Goldstein","year":"1971"},{"key":"b3","series-title":"CR Acad Sci Paris","first-page":"783","article-title":"Endorphines, peptides, d'origine hypothalamique et neurohypophysaire \u00e0 activit\u00e9 morphinomim\u00e9tique. Isolement et structure mol\u00e9culaire de l'alpha-endorphine.","volume":"282","author":"Guillemin","year":"1976"},{"key":"b4","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"582","DOI":"10.3171\/jns.1971.34.4.0582","article-title":"Transsphenoidal hypophysectomy.","volume":"34","author":"Hardy","year":"1971"},{"key":"b5","series-title":"Proc Natl Acad Sci USA","doi-asserted-by":"publisher","first-page":"2895","DOI":"10.1073\/pnas.73.8.2895","article-title":"Betaendorphin is a potent analgesic agent.","volume":"73","author":"Loh","year":"1976"},{"key":"b6","series-title":"Advances in Neurology, Volume 4. Pain.","first-page":"707","article-title":"Chemical hypophysectomy for cancer pain","author":"Moricca","year":"1974"},{"key":"b7","series-title":"Anaesthesiology.","first-page":"271","article-title":"Chemolysis of the pituitary in the management of cancer pain","author":"Moricca","year":"1973"},{"key":"b8","series-title":"Characterization of Human Tumors.","first-page":"218","article-title":"Hormonal control of malignant tumors","volume":"vol 1","author":"Moricca","year":"1973"},{"key":"b9","series-title":"South Med J","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1097\/00007611-197605000-00029","article-title":"Hypophysectomy in the treatment of disseminated carcinoma of the breast and prostate gland.","volume":"69","author":"Tindall","year":"1976"},{"key":"b10","series-title":"The Pituitary. A Current Review.","first-page":"399","article-title":"Transsphenoidal hypophysectomy for disseminated carcinoma of the breast and prostate gland","author":"Tindall","year":"1977"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/47\/5\/article-p659.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/47\/5\/article-p659.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/47\/5\/article-p659.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T13:41:46Z","timestamp":1666532506000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/47\/5\/article-p659.xml"}},"subtitle":["A preliminary report"],"short-title":[],"issued":{"date-parts":[[1977,11]]},"references-count":10,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.3171\/jns.1977.47.5.0659","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[1977,11]]}}}