{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:09:54Z","timestamp":1791230994891,"version":"4.1.0"},"reference-count":16,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1977,11]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Simple lacerations of dog anterior tibial nerves were repaired utilizing fascicular, interfascicular, and epineural suture techniques. Two months following repair, the involved regions of the nerves were removed and stained with hematoxylin and eosin, Weil, Bielschowsky, and Masson trichrome stains. An independent, unbiased observer rated proximal and distal myelin, connective tissue responses, and proximal to distal axon counts. The proportion of proximal to distal axons revealed no significant difference between fascicular (77%) and epineural (67%) neurorrhaphy, but showed a significant beneficial effect of fascicular suture to the interfascicular (52%) repair (significance at &lt; 0.02). Masson stain revealed dense connective tissue responses, but the axon counts were adversely affected only when the separate fascicles showed internal disruption by connective tissue. In general, distal myelinization was mildly superior with the fascicular neurorrhaphy technique.<\/jats:p>\n<jats:p content-type=\"fine-print\">It appears that in simple lacerations in nerves which are repaired via direct end-to-end suture, there is no significant advantage to fascicular over epineural repair; however, there is a definite deleterious effect of interfascicular neurorrhaphy. The theoretical and technical implications of these findings are discussed.<\/jats:p>","DOI":"10.3171\/jns.1977.47.5.0744","type":"journal-article","created":{"date-parts":[[2009,5,7]],"date-time":"2009-05-07T15:15:37Z","timestamp":1241709337000},"page":"744-750","source":"Crossref","is-referenced-by-count":52,"title":["Comparison of fascicular, interfascicular, and epineural suture techniques in the repair of simple nerve lacerations"],"prefix":"10.3171","volume":"47","author":[{"given":"Robert","family":"Levinthal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Jann Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Rand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Bone Joint Surg","first-page":"659","article-title":"Peripheral nerve repair in cats. The fascicular stitch.","volume":"49A","author":"Bora","year":"1967"},{"key":"b2","series-title":"Acta Chir Scand [Suppl]","first-page":"1","article-title":"Peripheral nerve suture. A technique for improved intraneural topography evaluation of some suture materials.","volume":"331","author":"Edshage","year":"1964"},{"key":"b3","series-title":"J Bone Joint Surg","first-page":"1178","article-title":"Funicular orientation by direct stimulation. An aid to peripheral nerve repair.","volume":"50A","author":"Hakstian","year":"1968"},{"key":"b4","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"968","DOI":"10.3171\/jns.1964.21.11.0968","article-title":"A comparative study of response of species to peripheral-nerve injury. I. Severance.","volume":"21","author":"Kline","year":"1964"},{"key":"b5","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"980","DOI":"10.3171\/jns.1964.21.11.0980","article-title":"A comparative study of response of species to peripheral-nerve injury. II. Crush and severance with primary suture.","volume":"21","author":"Kline","year":"1964"},{"key":"b6","series-title":"J Physiol (Lond)","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1113\/jphysiol.1917.sp001805","article-title":"On the suture of separate nerve bundles in a nerve trunk and on internal nerve plexuses.","volume":"51","author":"Langley","year":"1917"},{"key":"b7","series-title":"Microsurgery","article-title":"Microsurgical and theoretical aspects of nerve allografting","author":"Levinthal"},{"key":"b8","series-title":"J Bone Joint Surg","first-page":"390","article-title":"Effects of stretching the tibial nerve of the rabbit.","volume":"55B","author":"Lundborg","year":"1973"},{"key":"b9","series-title":"J Bone Joint Surg","first-page":"727","article-title":"The interfascicular nerve-grafting of the median and ulnar nerve.","volume":"54A","author":"Millesi","year":"1972"},{"key":"b10","series-title":"Advances and Technical Standards in Neurosurgery","first-page":"33","article-title":"Modern aspects of peripheral and cranial nerve surgery","volume":"2","author":"Samii","year":"1975"},{"key":"b11","series-title":"Surgical Disorders of the Peripheral Nerves","author":"Sedden","year":"1972"},{"key":"b12","series-title":"Plast Reconstr Surg","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1097\/00006534-196404000-00002","article-title":"Microsurgery of peripheral nerves.","volume":"33","author":"Smith","year":"1964"},{"key":"b13","series-title":"Brain","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1093\/brain\/88.4.841","article-title":"The connective tissue of peripheral nerves.","volume":"88","author":"Sunderland","year":"1965"},{"key":"b14","series-title":"Br J Surg","first-page":"580","article-title":"Funicular suture and funicular exclusion in the repair of severed nerves.","volume":"40","author":"Sunderland","year":"1953"},{"key":"b15","series-title":"Brain","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1093\/brain\/68.4.243","article-title":"The intraneural topography of the radial median and ulnar nerves.","volume":"68","author":"Sunderland","year":"1945"},{"key":"b16","series-title":"Nerves and Nerve Injuries","author":"Sunderland","year":"1968"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/47\/5\/article-p744.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/47\/5\/article-p744.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/47\/5\/article-p744.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T13:41:59Z","timestamp":1666532519000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/47\/5\/article-p744.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,11]]},"references-count":16,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.3171\/jns.1977.47.5.0744","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[1977,11]]}}}