{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T11:26:28Z","timestamp":1784028388613,"version":"3.55.0"},"reference-count":7,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1978,5]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 The authors describe a case in which 0.5 cc of 5% fluorescein diluted in 10 cc of cerebrospinal fluid (CSF) was injected at the L4\u20135 level for evaluation of nasal CSF leakage. Within minutes, tone increased in lower extremities accompanied by knee and ankle clonus and subjective numbness up to the waist. Non-preserved saline irrigation of the lumbar CSF was administered until it became clear, and the patient's head was elevated to retard the developing symptomatology. Although a transient temperature elevation was observed with negative CSF cultures, all signs and symptoms cleared within 48 hours. In a survey of the members of the American Association of Neurological Surgeons regarding frequency of use and complications stemming from intrathecal fluorescein, the response rate was 58.3% (1111) of the 1907 members, of which 6.8% (76) had used intrathecal fluorescein, and among those, 25% (19 of the 76) had observed complications involving lower extremity weakness, numbness, generalized seizure activity, opisthotonos, and cranial nerve deficit. No complications were permanent. The authors recommend caution if intrathecal fluorescein must be used. Means should be available to clear the CSF of the agent and elevate the head if complications arise.<\/jats:p>","DOI":"10.3171\/jns.1978.48.5.0765","type":"journal-article","created":{"date-parts":[[2009,5,7]],"date-time":"2009-05-07T15:29:39Z","timestamp":1241710179000},"page":"765-767","source":"Crossref","is-referenced-by-count":84,"title":["Spectrum of complications in the use of intrathecal fluorescein"],"prefix":"10.3171","volume":"48","author":[{"given":"John I.","family":"Moseley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles A.","family":"Carton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Eugene","family":"Stern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Microsurgery, Part II.","article-title":"Extracranial microsurgical approaches to cerebrospinal fluid leaks","author":"Calcaterra"},{"key":"b2","series-title":"Ann Otol Rhinol Laryngol","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1177\/000348943804700316","article-title":"Spontaneous cerebrospinal fluid rhinorrhea.","volume":"47","author":"Friedberg","year":"1938"},{"key":"b3","series-title":"Trans Am Acad Ophthalmol Otolaryngol","first-page":"916","article-title":"Spontaneous cerebrospinal rhinorrhea from the sphenoid sinus.","volume":"84","author":"Jenkins","year":"1977"},{"key":"b4","series-title":"Surg Forum","first-page":"406","article-title":"Use of fluorescein for the diagnosis and localization of cerebrospinal fluid fistulas.","volume":"12","author":"Kirchner","year":"1961"},{"key":"b5","series-title":"Trans Am Laryngol Rhinol Otol Soc","first-page":"786","article-title":"Method for the identification and localization of cerebrospinal fluid, rhinorrhea and otorrhea.","volume":"47","author":"Kirchner","year":"1960"},{"key":"b6","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"298","DOI":"10.3171\/jns.1966.25.3.0298","article-title":"Complication following intrathecal injection of fluorescein. Case report.","volume":"25","author":"Mahaley","year":"1966"},{"key":"b7","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"659","DOI":"10.3171\/jns.1972.36.5.0659","article-title":"Status epilepticus as a complication of intrathecal fluorescein.","volume":"36","author":"Wallace","year":"1972"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/48\/5\/article-p765.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/48\/5\/article-p765.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/48\/5\/article-p765.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T14:30:38Z","timestamp":1666535438000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/48\/5\/article-p765.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,5]]},"references-count":7,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.3171\/jns.1978.48.5.0765","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[1978,5]]}}}