{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T21:52:20Z","timestamp":1761947540583},"reference-count":14,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1978,6]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Intraspinal steroids have been recommended for the treatment of sciatica and various other conditions. The procedure is controversial; moreover, evidence suggests that the steroid hormones can be delivered to the site of inflammation more easily by systemic administration. Serious complications that have arisen from the procedure are reviewed. The courses of two women who received intraspinal steroids for the treatment of sciatica and who developed severe meningitis as a consequence are reported. It is suggested that the value of intraspinal steroids in the treatment of disc-related sciatica is unproven and if they are used, one must be alert to the complications.<\/jats:p>","DOI":"10.3171\/jns.1978.48.6.1023","type":"journal-article","created":{"date-parts":[[2009,5,7]],"date-time":"2009-05-07T15:31:27Z","timestamp":1241710287000},"page":"1023-1025","source":"Crossref","is-referenced-by-count":75,"title":["Complications following intraspinal injections of steroids"],"prefix":"10.3171","volume":"48","author":[{"given":"John H.","family":"Dougherty","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard A. R.","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Neurol Neurosurg Psychiatry","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1136\/jnnp.39.11.1124","article-title":"Sclerosing spinal pachymeningitis. A complication of intrathecal administration of Depo-Medrol for multiple sclerosis.","volume":"39","author":"Bernat","year":"1976"},{"key":"b2","series-title":"Br Med J","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1136\/bmj.2.5867.635","article-title":"Extradural corticosteroid injection in management of lumbar nerve root compression.","volume":"2","author":"Dilke","year":"1973"},{"key":"b3","series-title":"Orthop Clin North Am","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/S0030-5898(20)31215-3","article-title":"Regional use of steroids in the management of lumbar intervertebral disc disease.","volume":"6","author":"Feffer","year":"1975"},{"key":"b4","series-title":"J Bone Joint Surg","first-page":"585","article-title":"Treatment of low-back and sciatic pain by the injection of hydrocortisone into degenerated intervertebral discs.","volume":"38A","author":"Feffer","year":"1956"},{"key":"b5","series-title":"Trans Am Neurol Assoc","first-page":"214","article-title":"Intraspinal corticosteroids in the treatment of sciatica.","volume":"86","author":"Gardner","year":"1961"},{"key":"b6","series-title":"J Neurol Neurosurg Psychiatry","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1136\/jnnp.38.12.1211","article-title":"Dexamethasone in the management of symptoms due to herniated lumbar disc.","volume":"38","author":"Green","year":"1975"},{"key":"b7","series-title":"N Engl J Med","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1056\/NEJM197609022951007","article-title":"Corticosteroids and growth.","volume":"295","author":"Loeb","year":"1976"},{"key":"b8","series-title":"Ann Intern Med","doi-asserted-by":"publisher","first-page":"505","DOI":"10.7326\/0003-4819-81-4-505","article-title":"Systemic corticosteroid therapy: pharmacology and endocrinologic considerations.","volume":"81","author":"Melby","year":"1974"},{"key":"b9","series-title":"Arch Neurol","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1001\/archneur.1976.00500050059015","article-title":"Arachnoiditis from intrathecally given corticosteroids in the treatment of multiple sclerosis.","volume":"33","author":"Nelson","year":"1976"},{"key":"b10","series-title":"Acta Neurol Scand","first-page":"176","article-title":"Complications from intrathecal steroid therapy in patients with multiple sclerosis.","volume":"49","author":"Nelson","year":"1973"},{"key":"b11","series-title":"JAMA","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1001\/jama.1967.03120230146032","article-title":"Tuberculous meningitis after intrathecally administered methylprednisolone acetate.","volume":"200","author":"Roberts","year":"1967"},{"key":"b12","series-title":"Trans Am Neurol Assoc","first-page":"275","article-title":"Placement of intrathecal methylprednisolone acetate in neurological disorders.","volume":"88","author":"Sehgal","year":"1963"},{"key":"b13","series-title":"JAMA","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1001\/jama.1966.03110130104035","article-title":"Dangers of spinal injections without proper diagnosis.","volume":"197","author":"Shealy","year":"1966"},{"key":"b14","series-title":"Anesth Analg","first-page":"990","article-title":"Pain Clinic II: Intradural and extradural corticosteroids for sciatica.","volume":"51","author":"Winnie","year":"1972"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/48\/6\/article-p1023.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/48\/6\/article-p1023.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/48\/6\/article-p1023.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T14:19:37Z","timestamp":1666534777000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/48\/6\/article-p1023.xml"}},"subtitle":["Report of two cases"],"short-title":[],"issued":{"date-parts":[[1978,6]]},"references-count":14,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.3171\/jns.1978.48.6.1023","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[1978,6]]}}}