{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T03:59:04Z","timestamp":1780113544923,"version":"3.54.0"},"reference-count":17,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1978,11]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Of 48 cases of subependymoma reported to date, 22 were associated with symptoms. In a personal series of 47 additional cases of subependymoma reviewed by the author, 21 were symptomatic. The mean age of patients with symptom-producing subependymomas was 39 years, that is, 20 years younger than that of patients with asymptomatic tumors. Symptoms were most often produced by large tumors, particularly those arising from the septum pellucidum (100%), the floor of the fourth ventricle (65%), and the lateral ventricular walls (55%). The majority of symptomatic tumors displayed the classic gross and microscopic features of subependymomas; however, large tumors more frequently demonstrated cyst formation, microcalcification, and vessel degeneration accompanied by hemorrhage. Of all subependymomas, 15% were microscopically composed of an admixture of classic subependymoma and cellular ependymoma; of these, one-half occurred within the first decade, all were situated in the fourth ventricle, and 80% were symptomatic. In contrast to pure subependymomas, the mortality rate of patients with mixed tumors was 80%, reflecting their growth potential, large size, and dangerous location.<\/jats:p>","DOI":"10.3171\/jns.1978.49.5.0689","type":"journal-article","created":{"date-parts":[[2009,5,7]],"date-time":"2009-05-07T15:24:00Z","timestamp":1241709840000},"page":"689-696","source":"Crossref","is-referenced-by-count":131,"title":["Symptomatic subependymoma"],"prefix":"10.3171","volume":"49","author":[{"given":"Bernd W.","family":"Scheithauer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Acta Neuropathol","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/BF00691968","article-title":"Subependymoma: a case report with ultrastructural study.","volume":"40","author":"Azzarelli","year":"1977"},{"key":"b2","series-title":"J Neuropathol Exp Neurol","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1097\/00005072-195401000-00006","article-title":"Subependymal glomerate astrocytomas.","volume":"13","author":"Boykin","year":"1954"},{"key":"b3","series-title":"J Neuropathol Exp Neurol","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1097\/00005072-195610000-00008","article-title":"Subependymal mixed gliomas.","volume":"15","author":"Chason","year":"1956"},{"key":"b4","series-title":"Am J Pathol","first-page":"839","article-title":"The cytology of the glioma group; with special reference to the inclusion of cells derived from the invaded tissue.","volume":"9","author":"Cox","year":"1933"},{"key":"b5","series-title":"Am J Pathol","first-page":"539","article-title":"Electron microscopic observations on astrocytomas.","volume":"43","author":"Duffell","year":"1963"},{"key":"b6","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"433","DOI":"10.3171\/jns.1948.5.5.0433","article-title":"Tumors of the septum pellucidum.","volume":"5","author":"French","year":"1948"},{"key":"b7","series-title":"Cancer","doi-asserted-by":"publisher","first-page":"1992","DOI":"10.1002\/1097-0142(197412)34:6<1992::AID-CNCR2820340618>3.0.CO;2-C","article-title":"Is subependymoma (subependymal glomerate astrocytoma) an astrocytoma or ependymoma? A comparative ultrastructural and tissue culture study.","volume":"34","author":"Fu","year":"1974"},{"key":"b8","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"385","DOI":"10.3171\/jns.1959.16.4.0385","article-title":"Subependymal glomerate astrocytoma. Report of two cases.","volume":"16","author":"Godwin","year":"1959"},{"key":"b9","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"640","DOI":"10.3171\/jns.1968.29.6.0640","article-title":"Subependymomas of the septum pellucidum. Report of two cases.","volume":"29","author":"Hehman","year":"1968"},{"key":"b10","series-title":"J Neurol Neurosurg Psychiatry","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1136\/jnnp.28.6.548","article-title":"Pedunculated gliomas in the lateral ventricle.","volume":"28","author":"Kunicki","year":"1965"},{"key":"b11","series-title":"Acta Psychiatr Neurol Scand","first-page":"331","article-title":"Cysts and tumors of the septum pellucidum.","volume":"19","author":"Riskaer","year":"1941"},{"key":"b12","series-title":"Arch Neurol Psychiatry","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1001\/archneurpsyc.1932.02230180010002","article-title":"Histologic classification of tumors of the central nervous system.","volume":"27","author":"Roussy","year":"1932"},{"key":"b13","series-title":"South Med J","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1097\/00007611-196509000-00014","article-title":"Subependymal glomerate astrocytoma.","volume":"58","author":"Rushing","year":"1965"},{"key":"b14","series-title":"Pathology of Tumours of the Nervous Sytem","author":"Russell","year":"1977"},{"key":"b15","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"232","DOI":"10.3171\/jns.1945.2.3.0232","article-title":"Subependymoma: a newly recognized tumor of subependymal derivation.","volume":"2","author":"Scheinker","year":"1945"},{"key":"b16","series-title":"Rev Neurol","first-page":"270","article-title":"Tumeur primitive du septum lucidum avec troubles dementiels.","volume":"38","author":"Souques","year":"1922"},{"key":"b17","series-title":"Zbl Allg Pathol Anat","first-page":"257","article-title":"Gliom des Septum-pellucidum mit Uebergang auf die Balkenausstrahlung.","volume":"31","author":"Wolf","year":"1920"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/49\/5\/article-p689.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/49\/5\/article-p689.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/49\/5\/article-p689.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,14]],"date-time":"2022-08-14T18:07:03Z","timestamp":1660500423000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/49\/5\/article-p689.xml"}},"subtitle":["Report of 21 cases with review of the literature"],"short-title":[],"issued":{"date-parts":[[1978,11]]},"references-count":17,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.3171\/jns.1978.49.5.0689","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[1978,11]]}}}