{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T12:45:29Z","timestamp":1773837929023,"version":"3.50.1"},"reference-count":18,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1978,12]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Serial postoperative angiograms were performed in 28 patients with intracranial aneurysms, 26 of whom had presented with a subarachnoid hemorrhage. The clinical state and intracranial pressure (ICP) were also measured. Angiograms were performed in the ward using a cannula, which was passed into the proximal external carotid artery via the superficial temporal artery. Measurements of the vessel diameters were made, with the preoperative angiogram as a baseline. Patients could be placed into one of five groups depending on the presence or absence of significant arterial spasm, the clinical state of the patient, and the normality or otherwise of the ICP. No patient's condition deteriorated without an elevated ICP and\/or significant arterial spasm. The study shows that this spasm is usually associated with a poor clinical state if it reaches a maximum 8 to 12 hours after the operation, although the clinical deterioration is not apparent for a further 6 to 12 hours. Knowledge of the natural history of postoperative arterial spasm may allow earlier treatment of the spasm, which may be more successful than delaying treatment until clinical deterioration has occurred. The worth of the varied drugs proposed for the treatment of spasm may be assessed using this type of protocol.<\/jats:p>","DOI":"10.3171\/jns.1978.49.6.0805","type":"journal-article","created":{"date-parts":[[2009,5,7]],"date-time":"2009-05-07T15:23:44Z","timestamp":1241709824000},"page":"805-815","source":"Crossref","is-referenced-by-count":35,"title":["An investigation with serial angiography into the evolution of cerebral arterial spasm following aneurysm surgery"],"prefix":"10.3171","volume":"49","author":[{"given":"Christopher B. T.","family":"Adams","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Fearnside","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean A.","family":"O'Laoire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Br Med J","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1136\/bmj.2.6036.607","article-title":"Intracranial aneurysms: analysis of results of microneurosurgery.","volume":"2","author":"Adams","year":"1976"},{"key":"b2","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3171\/jns.1965.22.1.0021","article-title":"Ruptured intracranial aneurysms. The role of arterial spasm.","volume":"22","author":"Allcock","year":"1965"},{"key":"b3","series-title":"Surg Neurol","first-page":"71","article-title":"Cerebral arterial spasm. Part 8: The treatment of delayed cerebral arterial spasm in human beings.","volume":"4","author":"Allen","year":"1976"},{"key":"b4","first-page":"76","article-title":"Clinical applications of intracranial pressure monitoring","author":"Azevedo Filho","year":"1975"},{"key":"b5","series-title":"Proc R Soc Med","first-page":"55","article-title":"Effects of intracranial dopamine perfusion: behavioural arousal and reversal of cerebral arterial spasm following surgery for clipping of ruptured cerebral aneurysms.","volume":"70","author":"Boullin","year":"1977"},{"key":"b6","series-title":"Br J Radiol","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1259\/0007-1285-47-557-257","article-title":"Per-operative cerebral angiography.","volume":"47","author":"Cummins","year":"1974"},{"key":"b7","series-title":"Cerebral Vascular Diseases, Seventh Conference.","first-page":"232","article-title":"Discussion of Symon L: Vasospasm in aneurysm","author":"Drake","year":"1971"},{"key":"b8","series-title":"Proc R Soc Med","first-page":"77","article-title":"The anaesthetist's effect upon the cerebral arteries.","volume":"64","author":"du Boulay","year":"1971"},{"key":"b9","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"49","DOI":"10.3171\/jns.1974.41.1.0049","article-title":"Sequential changes of vascular ultrastructure in experimental cerebral vasospasm. Myonecrosis of subarachnoid arteries.","volume":"41","author":"Fein","year":"1974"},{"key":"b10","series-title":"Arch Neurol Psychiatry","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1001\/archneurpsyc.1940.02280040191013","article-title":"Physiologic regulation of the cerebral circulation.","volume":"43","author":"Forbes","year":"1940"},{"key":"b11","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"515","DOI":"10.3171\/jns.1978.48.4.0515","article-title":"Cerebral artery spasm. A histological study at necropsy of the blood vessels in cases of subarachnoid hemorrhage.","volume":"48","author":"Hughes","year":"1978"},{"key":"b12","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3171\/jns.1968.28.1.0014","article-title":"Surgical risk as related to time of intervention in the repair of intracranial aneurysms.","volume":"28","author":"Hunt","year":"1968"},{"key":"b13","series-title":"Am J Roentgenol","first-page":"506","article-title":"The effect of changes in end expiratory carbon dioxide tension on the normal cerebral angiogram.","volume":"90","author":"Krueger","year":"1963"},{"key":"b14","author":"Loach"},{"key":"b15","series-title":"Arch Neurol","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1001\/archneur.1975.00490490037003","article-title":"Cerebral vasospasm and ruptured intracranial aneurysm.","volume":"32","author":"Millikan","year":"1975"},{"key":"b16","series-title":"Clin Neurosurg","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1093\/neurosurgery\/22.CN_suppl_1.29","article-title":"Cerebral vasospasm.","volume":"22","author":"Odom","year":"1975"},{"key":"b17","article-title":"Mural thrombosis as a cause of prolonged so called vasospasm following aneurysmal rupture.","author":"Someda"},{"key":"b18","series-title":"Background to Migraine. 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