{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T15:14:14Z","timestamp":1769354054696,"version":"3.49.0"},"reference-count":38,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1979,2]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Premature fusion of the coronal suture was produced in 9-day-old rabbits by immobilization of the suture area bilaterally with methyl-cyanoacrylate adhesive. The effects of suture fusion and its surgical release on suture growth and on skull morphology were evaluated by radiographic cephalometry. Immobilization resulted in significant changes in the angular dimensions in the vault toward an anteroposterior shortening. No permanent deformity was observed in the angular relationship between the cranial base and the facial skeleton. Craniectomy at 30 days, when a skull deformity had been established, resulted in rapid separation of the bones at the suture site which returned the deformed skull to a normal configuration by 90 days of age. Surgical removal of a normal suture in a control group also resulted in accelerated separation of the bones at the excised suture site, but it was less than after removal of an immobilized suture. The experimental data indicate that premature fusion of rapidly growing sutures results in consistent skull deformity. Early release of the fusion, when this is the primary abnormality, will result in spontaneous correction of the deformity.<\/jats:p>","DOI":"10.3171\/jns.1979.50.2.0187","type":"journal-article","created":{"date-parts":[[2009,5,7]],"date-time":"2009-05-07T15:38:51Z","timestamp":1241710731000},"page":"187-197","source":"Crossref","is-referenced-by-count":99,"title":["Craniofacial growth following experimental craniosynostosis and craniectomy in rabbits"],"prefix":"10.3171","volume":"50","author":[{"given":"K. Maurits","family":"Persson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William A.","family":"Roy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Persing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George T.","family":"Rodeheaver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Richard","family":"Winn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3171\/jns.1965.22.3.0229","article-title":"Craniosynostosis. A survey of 204 cases.","volume":"22","author":"Anderson","year":"1965"},{"key":"b2","series-title":"Acta Paediatr Scand","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1111\/j.1651-2227.1966.tb15225.x","article-title":"Craniosynostosis as a complication after operation for hydrocephalus.","volume":"55","author":"Andersson","year":"1966"},{"key":"b3","series-title":"Acta Paediatr Scand","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1111\/j.1651-2227.1968.tb07285.x","article-title":"Craniosynostosis. Review of the literature and indications for surgery.","volume":"57","author":"Andersson","year":"1968"},{"key":"b4","series-title":"Acta Ophthalmol","first-page":"1","article-title":"The premature synostosis of the cranial sutures.","author":"Bertelsen","year":"1958"},{"key":"b5","series-title":"Am J Anat","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1002\/aja.1000170404","article-title":"On the premature obliteration of sutures in the human skull.","volume":"17","author":"Bolk","year":"1915"},{"key":"b6","series-title":"Growth Including Reproduction and Morphological Development.","first-page":"346","article-title":"Organ weights from birth to maturity: Man, North American","author":"Boyd","year":"1962"},{"key":"b7","series-title":"Plast Reconstr Surg","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1097\/00006534-197407000-00002","article-title":"Craniofacial osteotomies and reconstructions in infants and young children.","volume":"54","author":"Edgerton","year":"1974"},{"key":"b8","series-title":"J Pediatr","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/S0022-3476(43)80168-2","article-title":"Early operation in premature cranial synostosis for the prevention of blindness and other sequelae. Five case reports with follow-up.","volume":"22","author":"Faber","year":"1943"},{"key":"b9","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"48","DOI":"10.3171\/jns.1975.43.1.0048","article-title":"Craniosynostosis.","volume":"43","author":"Foltz","year":"1975"},{"key":"b10","series-title":"Pediatrics","first-page":"57","article-title":"Craniostenosis. A review of the literature and report of thirty-four cases.","volume":"30","author":"Freeman","year":"1962"},{"key":"b11","series-title":"Anat Rec","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1002\/ar.1090880202","article-title":"Studies in skull growth. Coronal suture fixation.","volume":"88","author":"Giblin","year":"1944"},{"key":"b12","series-title":"J Exp Med","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1084\/jem.57.6.967","article-title":"Oxycephaly and allied conditions in man and in the rabbit.","volume":"57","author":"Greene","year":"1933"},{"key":"b13","series-title":"Biol Neonate","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1159\/000240527","article-title":"Growth and development of the rabbit brain.","volume":"21","author":"Harel","year":"1972"},{"key":"b14","series-title":"J Pediatr","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/S0022-3476(61)80264-3","article-title":"Craniosynostosis involving the sagittal suture only: Guilt by association?","volume":"58","author":"Hemple","year":"1961"},{"key":"b15","series-title":"Development and Aging in the Nervous System.","first-page":"151","article-title":"Neurochemical patterns in the developing and aging brain","author":"Himwich","year":"1973"},{"key":"b16","series-title":"Surgery","first-page":"518","article-title":"Clinical studies in craniosynostosis: Analysis of fifty cases and description of a method of surgical treatment.","volume":"24","author":"Ingraham","year":"1948"},{"key":"b17","series-title":"Z Gesamte Inn Med","first-page":"426","article-title":"Sch\u00e4deldynostosen.","volume":"7","author":"Jaensch","year":"1952"},{"issue":"(7)","key":"b18","series-title":"Birth Defects","first-page":"341","article-title":"Radical reconstruction of complex cranioorbitofacial abnormalities.","volume":"11","author":"Jane","year":"1975"},{"key":"b19","series-title":"Proc Finn Dent Soc","first-page":"1","article-title":"Adaptive sutures. Changes after unilateral masticatory muscle resection in rats.","volume":"77","author":"Koskinen","year":"1977"},{"key":"b20","series-title":"Acta Ophthalmol","first-page":"121","article-title":"Ophthalmological observations in craniosynostosis.","volume":"34","author":"Laitinen","year":"1956"},{"key":"b21","series-title":"Pediatrics","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1542\/peds.10.6.637","article-title":"Importance of early surgical treatment of craniosynostosis. Review of thirty six cases treated during the first six months of life.","volume":"10","author":"McLaurin","year":"1952"},{"key":"b22","series-title":"Am J Phys Anthropol","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1002\/ajpa.1330230312","article-title":"Cranial base morphology in association with intentional cranial vault deformation.","volume":"23","author":"McNeil","year":"1965"},{"key":"b23","series-title":"Anat Rec","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1002\/ar.1091650305","article-title":"Age changes in the cranial base of the rabbit (Oryctolagus cuniculus).","volume":"165","author":"Moore","year":"1969"},{"key":"b24","series-title":"Childs Brain","first-page":"22","article-title":"Functional anatomy of cranial synostosis.","volume":"1","author":"Moss","year":"1975"},{"key":"b25","series-title":"Am J Anat","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1002\/aja.1000940302","article-title":"Growth of the calvaria in the rat. The determination of osseous morphology.","volume":"94","author":"Moss","year":"1954"},{"key":"b26","series-title":"Am J Phys Anthropol","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1002\/ajpa.1330160302","article-title":"The pathogenesis of artificial cranial deformation.","volume":"16","author":"Moss","year":"1958"},{"key":"b27","series-title":"Acta Anat","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1159\/000141479","article-title":"The pathogenesis of premature cranial synostosis in man.","volume":"37","author":"Moss","year":"1959"},{"key":"b28","series-title":"Acta Neurochir","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/BF01406556","article-title":"Neue Gesichtspunkte zue Pathogenese und Therapie der Kraniosynostose. (Zweiter Teil.)","volume":"26","author":"M\u00fcke","year":"1972"},{"key":"b29","series-title":"J Pediatr","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/S0022-3476(75)80963-2","article-title":"Premature craniosynostosis \u2014 a complication of thyroid replacement therapy.","volume":"86","author":"Penfold","year":"1975"},{"key":"b30","series-title":"Odontol Revy","first-page":"1","article-title":"Structure and growth of facial sutures. Histologic, microangiography and autoradiographic studies in rats and a histologic study in man.","volume":"24","author":"Persson","year":"1973"},{"key":"b31","series-title":"J Pediatr","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/S0022-3476(64)80192-X","article-title":"Craniosynostosis in the rachitic spectrum.","volume":"64","author":"Reilly","year":"1964"},{"key":"b32","series-title":"Z Kinderheilkunde","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/BF00438521","article-title":"Zur Pathogenese des Turmsch\u00e4dels, der Dysostosis craniofacial sowie der Acrocephalosyndaktylie.","volume":"79","author":"Sch\u00f6nenberg","year":"1957"},{"key":"b33","series-title":"Radiology","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1148\/101.3.631","article-title":"Premature closure of the frontosphenoidal suture in synostosis of the coronal suture.","volume":"101","author":"Seeger","year":"1971"},{"key":"b34","series-title":"Pediatrics","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1542\/peds.41.4.829","article-title":"Craniosynostosis: a review of 519 surgical patients.","volume":"41","author":"Shillito","year":"1968"},{"key":"b35","series-title":"Plast Reconstr Surg","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1097\/00006534-197705000-00013","article-title":"The pathogenesis of premature craniosynostosis in acrocephalosyndactyly (Apert's syndrome). A reconsideration.","volume":"59","author":"Stewart","year":"1977"},{"key":"b36","series-title":"Plast Reconstr Surg","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1097\/00006534-197109000-00005","article-title":"Relationship of craniostenoses to craniofacial dysostoses, and to faciostenoses. A study with therapeutic implications.","volume":"48","author":"Tessier","year":"1971"},{"key":"b37","series-title":"Verh Phys Med Gesamte Wurzburg","first-page":"230","article-title":"\u00dcber den Cretinismus, namentlich in Franken, und \u00fcber pathologische Sch\u00e4delformen.","volume":"2","author":"Virchow","year":"1851\u20131852"},{"key":"b38","series-title":"Plast Reconstr Surg","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1097\/00006534-197710000-00013","article-title":"Early surgery for isolated craniofacial dysostosis. Improvement and possible prevention of increasing deformity.","volume":"60","author":"Whitaker","year":"1977"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/50\/2\/article-p187.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/50\/2\/article-p187.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/50\/2\/article-p187.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T20:47:47Z","timestamp":1679863667000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/50\/2\/article-p187.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,2]]},"references-count":38,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3171\/jns.1979.50.2.0187","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[1979,2]]}}}