{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:12:21Z","timestamp":1760955141722},"reference-count":17,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1979,5]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Regional cerebral blood flow (CBF) was measured by the microsphere technique in anesthetized, mechanically ventilated dogs before and after cervical laminectomy in four (control group), or cervical laminectomy followed by cervical cord transection (CCT) at the C-6 level in six (experimental group). No significant differences in arterial pH, pO<jats:sub>2<\/jats:sub> or pCO<jats:sub>2<\/jats:sub> were observed between control and experimental dogs. Baseline values for mean arterial pressure (MAP) were also similar in the two groups, but MAP fell in all experimental dogs after CCT (p &lt; 0.025). At 120 minutes after CCT, three of the six dogs had an MAP &gt; 60 torr (66 \u00b1 4 torr), and in three the MAP was &lt; 50 torr (45 \u00b1 3 torr). Regional CBF in cortical gray matter, white matter, and medulla did not change significantly after CCT in dogs with MAP &gt; 60 torr. The CBF fell significantly at 120 minutes after CCT in all regions sampled in the dogs with MAP &lt; 50 torr (p &lt; 0.025). At 30 and 120 minutes after CCT, cerebellar blood flow fell significantly in all experimental animals (p &lt; 0.05).<\/jats:p>\n<jats:p content-type=\"fine-print\">These findings indicate that, despite hypotension and sympathetic denervation of cerebral vessels, CBF in cortical gray matter, white matter, and medulla is maintained at normal levels after CCT by autoregulation as long as MAP exceeds 60 torr. Decreased cerebellar blood flow in the experimental group suggests redistribution of CBF after CCT with relative preservation of flow to gray matter, white matter, and medulla. Reduced CBF in the acutely cord-injured patient with significant hypotension (MAP &lt; 60 torr) may simulate or complicate coexistent head injury.<\/jats:p>","DOI":"10.3171\/jns.1979.50.5.0633","type":"journal-article","created":{"date-parts":[[2009,5,7]],"date-time":"2009-05-07T15:39:06Z","timestamp":1241710746000},"page":"633-638","source":"Crossref","is-referenced-by-count":7,"title":["Studies of experimental cervical spinal cord transection"],"prefix":"10.3171","volume":"50","author":[{"given":"Phillip A.","family":"Tibbs","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byron","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. G.","family":"McAllister","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward P.","family":"Todd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Circ Res","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1161\/01.RES.37.5.550","article-title":"Effects of decreasing arterial blood pressure on cerebral blood flow in the baboon. 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Effect of sympathetic denervation in dogs.","volume":"41","author":"Mueller","year":"1977"},{"key":"b11","series-title":"Blood Vessels","first-page":"2","article-title":"Autonomic neuroreceptor mechanisms in brain vessels.","volume":"11","author":"Owman","year":"1974"},{"key":"b12","series-title":"J Clin Invest","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.1172\/JCI104623","article-title":"Cerebral circulation and metabolism during thiopental anesthesia and hyperventilation in man.","volume":"41","author":"Pierce","year":"1962"},{"key":"b13","series-title":"Circ Res","first-page":"205","article-title":"Autoregulation of canine cerebral blood flow.","volume":"15","author":"Rapela","year":"1964"},{"key":"b14","series-title":"Am J Physiol","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1152\/ajplegacy.1970.219.1.96","article-title":"Total and regional cerebral blood flow in unanesthetized dogs.","volume":"219","author":"Roth","year":"1970"},{"key":"b15","series-title":"Ann Surg","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1097\/00000658-196605000-00014","article-title":"Factors affecting cerebral blood flow \u2014 Experimental review. 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