{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:29:10Z","timestamp":1767706150592},"reference-count":11,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1980,2]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 An experimental model of spinal cord compression by epidural neoplasms was produced in rabbits by injecting a VX<jats:sub>2<\/jats:sub> tumor-cell suspension anterior to the T-13 vertebral body. With this experimental model, edema and circulatory disturbance of the spinal cord compressed by epidural tumors were studied. The characteristic histopathological findings in the compressed spinal cord were edema and axonal swelling in the white matter. Water content and uptake of intravenously injected <jats:sup>99m<\/jats:sup>Tc pertechnetate in the compressed spinal cord were significantly greater than in the spinal cord distant from the tumor, and increased in proportion to the degree of neurological loss. Microangiography and fluorescein angiography demonstrated stenosis or obstruction of the epidural venous plexus and impairment of venous drainage in the compressed spinal cord at the early stage of neurological symptoms. It is suggested that venous stasis and subsequent vasogenic edema in the spinal cord play an important role in the symptomatology of metastatic epidural spinal cord compression.<\/jats:p>","DOI":"10.3171\/jns.1980.52.2.0203","type":"journal-article","created":{"date-parts":[[2009,5,7]],"date-time":"2009-05-07T15:47:18Z","timestamp":1241711238000},"page":"203-209","source":"Crossref","is-referenced-by-count":41,"title":["Edema and circulatory disturbance in the spinal cord compressed by epidural neoplasms in rabbits"],"prefix":"10.3171","volume":"52","author":[{"given":"Hiroya","family":"Ikeda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukitaka","family":"Ushio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Hayakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heitaro","family":"Mogami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Arch Neurol","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1001\/archneur.1966.00470130104012","article-title":"Metastatic spinal epidural tumors. An analysis of 50 cases.","volume":"15","author":"Auld","year":"1966"},{"key":"b2","series-title":"The Spinal Cord. Basic Aspects and Surgical Considerations","first-page":"444","author":"Austin","year":"1972"},{"key":"b3","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1212\/WNL.9.2.91","article-title":"Experience with metastatic neoplasms involving the spinal cord.","volume":"9","author":"Barron","year":"1959"},{"key":"b4","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"653","DOI":"10.3171\/jns.1977.47.5.0653","article-title":"Indication for nonoperative treatment of spinal cord compression due to breast cancer.","volume":"47","author":"Cobb","year":"1977"},{"key":"b5","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"277","DOI":"10.3171\/jns.1971.35.3.0277","article-title":"Microangiographic study of experimental spinal cord injuries.","volume":"35","author":"Fairholm","year":"1971"},{"key":"b6","series-title":"Shinkeikenkyu-no-shinpo (Tokyo)","first-page":"616","article-title":"[Pathology of spinal cord softening caused by leukemia: Venous infarction of the spinal cord due to tumor infiltration of the vertebral venous plexus.]","volume":"18","author":"Nagashima","year":"1974"},{"key":"b7","series-title":"Mem Hosp Clin Bull","first-page":"65","article-title":"Spinal cord compression: a neurological emergency.","volume":"1","author":"Posner","year":"1971"},{"key":"b8","series-title":"Arch Neurol","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1001\/archneur.1974.00490330025004","article-title":"Corticosteroid hormones. Effects in an experimental brain tumor.","volume":"30","author":"Shapiro","year":"1974"},{"key":"b9","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"380","DOI":"10.3171\/jns.1977.47.3.0380","article-title":"Treatment of experimental spinal cord compression caused by extradural neoplasms.","volume":"47","author":"Ushio","year":"1977"},{"key":"b10","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1212\/WNL.27.5.422","article-title":"Experimental spinal cord compression by extradural neoplasms.","volume":"27","author":"Ushio","year":"1977"},{"key":"b11","series-title":"Cancer","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1002\/1097-0142(197103)27:3<558::AID-CNCR2820270307>3.0.CO;2-E","article-title":"Role of surgery in the treatment of spinal cord compression by metastatic neoplasm.","volume":"27","author":"White","year":"1971"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/52\/2\/article-p203.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/52\/2\/article-p203.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/52\/2\/article-p203.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T00:47:18Z","timestamp":1679273238000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/52\/2\/article-p203.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,2]]},"references-count":11,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3171\/jns.1980.52.2.0203","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[1980,2]]}}}