{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T21:06:57Z","timestamp":1784063217263,"version":"3.55.0"},"reference-count":40,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1980,3]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Local cerebral blood volume (CBV) was mapped in 10 normal subjects and in 30 patients after head injury. In normal subjects, the mean CBV was 4.34 ml\/100 gm. The coefficient of variation was 12% for the group mean, and 3% for values obtained in duplicate studies of individuals. Patients with head injuries were divided into three groups according to the stage of their illness: acute illness, early recovery, and later recovery. Averages of mean CBV were within one standard deviation of normal. In contrast, consistent changes were found in serial studies of the mean CBV in the same patient. Compared to recovery values, levels of mean CBV measured soon after injury were reduced, largely at the expense of the gray-matter compartment. In five adults with predominantly unilateral lesions, there was an average early reduction in mean CBV and cerebral blood flow of 15% and 36%, respectively. In three children with diffuse brain swelling, there was an average early mean CBV reduction of 12%; a single child had early increased mean CBV at a time when intracranial pressure was high. Greater changes were seen in local CBV on individual sections. There were mixed zones of hypervolemia and hypovolemia in regions of infarction and intracerebral hematoma. Subdural hematomas had consistent medial margins of increased local CBV, representing dilated blood vessels of the underlying cortex. The presence and displacement of this hypervolemic zone were sensitive indicators of persistent subdural collection and mass effect, even when the collection was lucent to x-ray computed tomography.<\/jats:p>","DOI":"10.3171\/jns.1980.52.3.0309","type":"journal-article","created":{"date-parts":[[2009,5,7]],"date-time":"2009-05-07T15:46:11Z","timestamp":1241711171000},"page":"309-320","source":"Crossref","is-referenced-by-count":81,"title":["Local cerebral blood volume in head-injured patients"],"prefix":"10.3171","volume":"52","author":[{"given":"David E.","family":"Kuhl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abass","family":"Alavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward J.","family":"Hoffman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Phelps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Zimmerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter D.","family":"Obrist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek A.","family":"Bruce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel H.","family":"Greenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Uzzell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Childs Brain","first-page":"174","article-title":"The pathophysiology, treatment, and outcome following severe head injury in children.","volume":"5","author":"Bruce","year":"1979"},{"key":"b2","series-title":"Blood Flow and Metabolism in the Brain.","first-page":"7.15","article-title":"Potential pitfalls in the measurement of regional cerebral blood volume","author":"Eichling","year":"1975"},{"key":"b3","series-title":"Circ Res","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1161\/01.RES.37.6.707","article-title":"In vivo determination of cerebral blood volume with radioactive oxygen-15 in the monkey.","volume":"37","author":"Eichling","year":"1975"},{"key":"b4","series-title":"J Neurol Neurosurg Psychiatry","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1136\/jnnp.37.12.1378","article-title":"Regional cerebral blood flow and intraventricular pressure in acute head injuries.","volume":"37","author":"Fieschi","year":"1974"},{"key":"b5","series-title":"Fed Proc","first-page":"2263","article-title":"Anatomical asymmetry as the basis for cerebral dominance.","volume":"37","author":"Geschwind","year":"1978"},{"key":"b6","series-title":"Circ Res","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1161\/01.RES.43.2.324","article-title":"Local cerebral blood volume response to carbon dioxide in man.","volume":"43","author":"Greenberg","year":"1978"},{"key":"b7","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1161\/01.STR.4.3.390","article-title":"The effects of arterial blood pressure on the regional cerebral blood volume by x-ray fluorescence.","volume":"4","author":"Grubb","year":"1973"},{"key":"b8","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"446","DOI":"10.3171\/jns.1977.46.4.0446","article-title":"Effects of subarachnoid hemorrhage on cerebral blood volume, blood flow, and oxygen utilization in humans.","volume":"46","author":"Grubb","year":"1977"},{"key":"b9","series-title":"Ann Neurol","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1002\/ana.410040407","article-title":"Measurement of regional cerebral blood volume by emission tomography.","volume":"4","author":"Grubb","year":"1978"},{"key":"b10","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"385","DOI":"10.3171\/jns.1975.43.4.0385","article-title":"Effects of increased intracranial pressure on cerebral blood volume, blood flow, and oxygen utilization in monkeys.","volume":"43","author":"Grubb","year":"1975"},{"key":"b11","series-title":"J Nucl Med","first-page":"1187","article-title":"Kit-produced 99mTc-labeled red cells for spleen imaging.","volume":"15","author":"Gutkowski","year":"1974"},{"key":"b12","series-title":"J Comput Assist Tomogr","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1097\/00004728-197906000-00001","article-title":"Quantitation in positron emission computed tomography. 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