{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:58:28Z","timestamp":1761807508012},"reference-count":38,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1980,5]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Ventricular cerebrospinal fluid (CSF) levels of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) were determined every 2 to 4 hours over a period of 1 to 4 days in 12 patients, consisting of seven cases of brain tumor, two cases of cerebrovascular disease, and three cases of head injury. The concentrations of HVA and 5-HIAA varied with time in all cases, and significant correlations were found between the two values in eight cases. However, the relationship between variations of HVA and 5-HIAA levels and rhythms of sleep and waking could not be clarified. Both HVA and 5-HIAA concentrations varied at high levels in two patients whose CSF flow was completely blocked by tumor at the site of the fourth ventricle and aqueduct, respectively. On the contrary, in a case with craniopharyngioma in the third ventricle which blocked the bilateral foramina of Monro, although the HVA values were high, the 5-HIAA values varied at low levels. Of five comatose patients, two had cerebrovascular lesions and three had sustained head injury, and, in four of the five, the values of either one or both of HVA and 5-HIAA were low, but in the fifth case the 5-HIAA value was high.<\/jats:p>\n<jats:p>Estimation of HVA and 5-HIAA concentrations in ventricular CSF may be a valuable tool in the investigation of brain monoamine metabolism. However, many factors must be considered in the interpretation of results of clinical studies.<\/jats:p>","DOI":"10.3171\/jns.1980.52.5.0635","type":"journal-article","created":{"date-parts":[[2009,5,7]],"date-time":"2009-05-07T15:43:40Z","timestamp":1241711020000},"page":"635-641","source":"Crossref","is-referenced-by-count":12,"title":["Homovanillic acid and 5-hydroxyindoleacetic acid in the ventricular CSF of comatose patients with obstructive hydrocephalus"],"prefix":"10.3171","volume":"52","author":[{"given":"Tetsuji","family":"Inagawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tohru","family":"Uozumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Lancet","first-page":"1049","article-title":"5-Hydroxyindole compounds in the cerebrospinal fluid of patients with psychiatric or neurological diseases.","volume":"2","author":"Ashcroft","year":"1966"},{"key":"b2","series-title":"J Physiol (Lond)","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1113\/jphysiol.1968.sp008660","article-title":"The active transport of 5-hydroxyindol-3-ylacetic acid and 3-methoxy-4-hydroxyphenylacetic acid from a recirculatory perfusion system of the cerebral ventricles of the unanaesthetized dog.","volume":"199","author":"Ashcroft","year":"1968"},{"key":"b3","series-title":"Acta Neurochir","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/BF01405944","article-title":"Monoamine acid metabolites in ventricular CSF of patients with brain tumours.","volume":"35","author":"Bareggi","year":"1976"},{"key":"b4","series-title":"Experientia","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1007\/BF01895283","article-title":"On the origin of homovanillic acid in the cerebrospinal fluid.","volume":"22","author":"Bartholini","year":"1966"},{"key":"b5","series-title":"Brain Res","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/0006-8993(75)90822-7","article-title":"Functional and biochemical aspects of catecholamine metabolism in brain under hypoxia.","volume":"85","author":"Brown","year":"1975"},{"key":"b6","series-title":"Brain Res","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/0006-8993(77)90308-0","article-title":"On the cerebral origin of 5-hydroxyindoleacetic acid in the lumbar cerebrospinal fluid.","volume":"122","author":"Bulat","year":"1977"},{"key":"b7","series-title":"J Pharm Pharmacol","first-page":"178","article-title":"Penetration of 5-hydroxyindoleacetic acid across the blood-cerebrospinal fluid barrier.","volume":"25","author":"Bulat","year":"1973"},{"key":"b8","series-title":"Am J Physiol","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1152\/ajplegacy.1971.220.3.718","article-title":"5-Hydroxyindoleacetic acid accumulation by isolated choroid plexus.","volume":"220","author":"Cserr","year":"1971"},{"key":"b9","series-title":"J Neurol Neurosurg Psychiatry","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1136\/jnnp.33.1.1","article-title":"The cerebrospinal fluid homovanillic acid concentration in patients with Parkinsonism treated with L-dopa.","volume":"33","author":"Curzon","year":"1970"},{"key":"b10","series-title":"Nature (New Biol)","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1038\/newbio231189a0","article-title":"Amine metabolites in the lumbar cerebrospinal fluid of humans with restricted flow of cerebrospinal fluid.","volume":"231","author":"Curzon","year":"1971"},{"key":"b11","series-title":"J Neurochem","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1111\/j.1471-4159.1973.tb07522.x","article-title":"The effect of hypoxia on monoamine synthesis, levels and metabolism in rat brain.","volume":"21","author":"Davis","year":"1973"},{"key":"b12","series-title":"J Neurochem","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1111\/j.1471-4159.1968.tb11637.x","article-title":"A comparison of 5-hydroxyindoles in various regions of dog brain and cerebrospinal fluid.","volume":"15","author":"Eccleston","year":"1968"},{"key":"b13","series-title":"Acta Neurol Scand","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1111\/j.1600-0404.1971.tb07500.x","article-title":"Brain concentrations of dopamine, noradrenaline, 5-hydroxytryptamine and homovanillic acid during intracranial hypertension following traumatic brain injury in rabbit.","volume":"47","author":"Edvinsson","year":"1971"},{"key":"b14","series-title":"Serotonin: New Vistas. 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