{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:33:29Z","timestamp":1790969609572,"version":"4.1.0"},"reference-count":58,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1980,6]]},"abstract":"<jats:p content-type=\"fine-print\">\n                    \u2713 The relationship among cerebral blood flow (CBF), blood volume, cardiac output (CO), and mean arterial blood pressure (MABP) at varying levels of arterial CO\n                    <jats:sub>2<\/jats:sub>\n                    tensions (PaCO\n                    <jats:sub>2<\/jats:sub>\n                    ) were studied in 70 normal cats. The CBF was measured from the clearance curve of xenon\n                    <jats:sub>\u2212133<\/jats:sub>\n                    and CO with a thermal dilution catheter placed in the pulmonary artery. The CBF, CO, and MABP values varied appropriately with changes in PaCO\n                    <jats:sub>2<\/jats:sub>\n                    , confirming the reliability of the preparations and the presence of normal autoregulatory responses. Moderate hypovolemia that did not change MABP did, nevertheless, significantly decrease CO and CBF. In an effort to determine if this decrease in CO and CBF were coupled responses, the effects of beta stimulation, hypervolemia, and alpha and beta blockade were investigated. Propranolol, in a dosage insufficient to change MABP, decreased both CO and CBF. This agent abolished the CO response to elevations in PaCO\n                    <jats:sub>2<\/jats:sub>\n                    but not the CBF response, making it unlikely that this CBF reduction resulted from impaired cerebral autoregulation. Isoproterenol, which, in contrast to propranolol, does not cross the normal blood-brain barrier, alone or in combination with phenoxybenzamine, produced a 38% and 72% increase in CO, respectively, without a change in CBF. Alpha blockade (no major change in CO) and beta blockade (major decrease in CO) did not significantly effect cerebral autoregulation to changes in MABP from angiotensin. The ability of the brain to resist increases in MABP and CO and maintain normal CBF is explained by normal cerebral autoregulation. However, its vulnerability to modest decreases in blood volume, which cannot be attributed to variations in perfusion pressure, is unexplained but obviously has important therapeutic implications. This may be related to reduction in CO, changes in autonomic activity, or a decrease in the size of the perfused capillary bed.\n                  <\/jats:p>","DOI":"10.3171\/jns.1980.52.6.0745","type":"journal-article","created":{"date-parts":[[2009,5,7]],"date-time":"2009-05-07T11:42:58Z","timestamp":1241696578000},"page":"745-754","source":"Crossref","is-referenced-by-count":86,"title":["Relationship of cerebral blood flow to cardiac output, mean arterial pressure, blood volume, and alpha and beta blockade in cats"],"prefix":"10.3171","volume":"52","author":[{"given":"Dudley H.","family":"Davis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thoralf M.","family":"Sundt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Circ Res","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1161\/01.RES.41.3.278","article-title":"Cerebral blood flow and vascular reactivity after removal of the superior cervical sympathetic ganglion in the goat.","volume":"41","author":"Alborch","year":"1977"},{"key":"b2","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1161\/01.STR.7.3.291","article-title":"Effect of beta-adrenergic blockade with propranolol on cerebral blood flow, autoregulation and CO2 responsiveness.","volume":"7","author":"Aqyagi","year":"1976"},{"key":"b3","series-title":"J Physiol","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1113\/jphysiol.1961.sp006657","article-title":"A comparison of the circulatory effects of angiotensin, vasopressin, and adrenaline in the anesthetized cat.","volume":"156","author":"Barer","year":"1961"},{"key":"b4","series-title":"Circ Res","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1161\/01.RES.38.6.488","article-title":"The relevance of peripheral baroreceptors and chemoreceptors to regulation of cerebral blood flow in the cat.","volume":"38","author":"Bates","year":"1976"},{"key":"b5","series-title":"Brain Res","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/0006-8993(77)90068-3","article-title":"The effect of lesions in the locus coeruleus on the physiological responses of the cerebral blood vessels in cats.","volume":"136","author":"Bates","year":"1977"},{"key":"b6","series-title":"J Physiol","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1113\/jphysiol.1952.sp004795","article-title":"Comparison of cardiac output determinations in the cat by direct Fick and flowmeter methods.","volume":"118","author":"Baxter","year":"1952"},{"key":"b7","series-title":"Circ Res","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1161\/01.RES.35.2.262","article-title":"Release of adenosine from ischemic brain. 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