{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T09:29:43Z","timestamp":1749634183713},"reference-count":18,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1980,8]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 The relative DNA content in 56 human intracranial tumors was investigated by flow cytometry and correlated to their histological type. Tumors with a modal DNA content within the diploid value (2c) \u00b1 \u00bdc were divided from those with heteroploidy. Of the \u201cbenign non-neuroepithelial tumors,\u201d the meningiomas (five), neurilemomas (two), pituitary adenomas (three), and one hemangioblastoma had a unimodal diploid\/neardiploid DNA content. The \u201cmalignant non-neuroepithelial tumors\u201d were both heteroploid (two metastatic carcinomas) and diploid\/near-diploid (three meningeal fibrosarcomas and one primary malignant lymphoma). Of the neuroepithelial tumors, the highly differentiated gliomas all had a diploid\/near-diploid DNA mode except one recurrent oligodendroglioma. The majority of the poorly differentiated gliomas also presented near-diploid DNA modes. Heteroploidy of primary brain tumors was not correlated with a more malignant clinical\/biological behavior in the individuals in this study.<\/jats:p>","DOI":"10.3171\/jns.1980.53.2.0198","type":"journal-article","created":{"date-parts":[[2009,5,7]],"date-time":"2009-05-07T15:40:56Z","timestamp":1241710856000},"page":"198-204","source":"Crossref","is-referenced-by-count":54,"title":["Modal DNA content of human intracranial neoplasms studied by flow cytometry"],"prefix":"10.3171","volume":"53","author":[{"given":"Sverre J.","family":"M\u00f8rk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ole D.","family":"Laerum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Br J Cancer","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1038\/bjc.1979.168","article-title":"Prognostic significance of modal DNA value and other factors in malignant tumours based on 1465 cases.","volume":"40","author":"Atkin","year":"1979"},{"key":"b2","series-title":"A Classification of the Tumors of the Glioma Group on a Histogenetic Basis with a Correlated Study of Prognosis","author":"Bailey","year":"1926"},{"key":"b3","series-title":"\u00c4rtzlich Lab","first-page":"77","article-title":"DNS-Messung von Zellen aus Vaginalabstrichen.","volume":"18","author":"Berkhan","year":"1972"},{"key":"b4","series-title":"Current Topics in Pathology","first-page":"151","article-title":"DNA in human tumors: a cytophotometric study","volume":"60","author":"B\u00f6hm","year":"1975"},{"key":"b5","series-title":"Histopathology","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1111\/j.1365-2559.1979.tb02987.x","article-title":"Cytophotometric DNA determination in human astroglial tumours.","volume":"3","author":"De Reuck","year":"1979"},{"key":"b6","series-title":"Z Naturforsch (B)","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1515\/znb-1969-0326","article-title":"Impulsfluorometrie bei Einzelzellen in Suspensionen.","volume":"24","author":"Dittrich","year":"1969"},{"key":"b7","series-title":"Acta Neuropathol","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/BF00690432","article-title":"Flow cytometry in tumours of the brain.","volume":"41","author":"Frederiksen","year":"1978"},{"key":"b8","series-title":"J Neuropathol Exp Neurol","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1097\/00005072-197605000-00135","article-title":"Flow microfluorometric studies of brain and brain tumors.","volume":"35","author":"Hoshino","year":"1976"},{"key":"b9","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3171\/jns.1978.49.1.0013","article-title":"The distribution of nuclear DNA from human brain-tumor cells. 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