{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:09:26Z","timestamp":1787508566190,"version":"build-2736575974"},"reference-count":22,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1980,9]]},"abstract":"<jats:p content-type=\"fine-print\">\n                    \u2713 The authors report four cases of primary intracranial choriocarcinoma, all in young males. Three tumors occurred in the pineal region and one in the lateral ventricle. Besides the signs of increased intracranial pressure and ophthalmological disorders, skin pigmentation or eruption was observed in three cases and precocious puberty in two cases. Angiography revealed tumor stain with irregular vessels in all cases. Enhanced computerized tomography scans in the last two cases demonstrated a round, lobulated lesion of high density, with relatively low density in the central portion. Hormonal study was carried out in three cases. In addition to high levels of human chorionic gonadotropin (HCG) in the urine and cerebrospinal fluid and\/or of plasma luteinizing hormone (LH), LH in the tumor tissue or medium obtained via cell cultures was also high in all three cases, suggesting inherent activity of HCG secretion by the tumor cells. The tumors were relatively demarcated from the surrounding brain. They were very hemorrhagic, and fresh hematoma was identified in the tumor in one case. Good results were obtained in two cases treated with surgical removal followed by simultaneous chemotherapy and\n                    <jats:sup>60<\/jats:sup>\n                    Co irradiation.\n                  <\/jats:p>","DOI":"10.3171\/jns.1980.53.3.0369","type":"journal-article","created":{"date-parts":[[2009,5,7]],"date-time":"2009-05-07T11:40:34Z","timestamp":1241696434000},"page":"369-374","source":"Crossref","is-referenced-by-count":37,"title":["Primary intracranial choriocarcinoma"],"prefix":"10.3171","volume":"53","author":[{"given":"Yasuto","family":"Kawakami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Tabuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Ohmoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Nishimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Pediatr","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/S0022-3476(61)80009-7","article-title":"Precocious puberty due to secreting chorionepithelioma (teratoma) of the brain.","volume":"59","author":"Bruton","year":"1961"},{"key":"b2","series-title":"Surgery","first-page":"306","article-title":"The endocrinologic aspects of tumors of the pineal gland.","volume":"16","author":"Davidoff","year":"1944"},{"key":"b3","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"246","DOI":"10.3171\/jns.1979.50.2.0246","article-title":"Primary intracranial endodermal sinus tumor. Case report.","volume":"50","author":"Eberts","year":"1979"},{"key":"b4","series-title":"J Pediatr","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/S0022-3476(65)80309-2","article-title":"Extragenital choriocarcinoma.","volume":"67","author":"Edmonds","year":"1965"},{"key":"b5","series-title":"Cancer","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1002\/1097-0142(195103)4:2<265::AID-CNCR2820040211>3.0.CO;2-X","article-title":"The comparative morphogenesis of extragenital and gonadal teratoid tumors.","volume":"4","author":"Friedman","year":"1951"},{"key":"b6","series-title":"Cancer Res","first-page":"363","article-title":"Germinoma of the pineal. Its identity with germinoma (\u201cseminoma\u201d) of the testis.","volume":"7","author":"Friedman","year":"1947"},{"key":"b7","series-title":"J Pediatr","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1016\/S0022-3476(40)80105-4","article-title":"Teratoma of the pineal body.","volume":"17","author":"Gerstley","year":"1940"},{"key":"b8","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"602","DOI":"10.3171\/jns.1975.42.5.0602","article-title":"Evolution of a primary intrasellar germinomatous teratoma into a choriocarcinoma. Case report.","volume":"42","author":"Giuffr\u00e8","year":"1975"},{"key":"b9","series-title":"JAMA","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1001\/jama.1972.03200020029007","article-title":"The chemotherapy of gestational trophoblastic disease. Principles of clinical management.","volume":"220","author":"Goldstein","year":"1972"},{"key":"b10","series-title":"Am J Obstet Gynecol","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/0002-9378(73)90389-X","article-title":"Treatment of metastatic trophoblastic disease: good and poor prognosis.","volume":"115","author":"Hammond","year":"1973"},{"key":"b11","series-title":"Med J Osaka Univ","first-page":"63","article-title":"Primary intracranial choriocarcinoma in the pineal region. A case report.","volume":"25","author":"Hasegawa","year":"1974"},{"key":"b12","series-title":"Arch Dis Child","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1136\/adc.44.238.732","article-title":"Sexual precocity due to an intracranial tumour causing unusual testicular secretion of testosterone.","volume":"44","author":"Hutchinson","year":"1969"},{"key":"b13","series-title":"Proc Soc Exp Biol Med","doi-asserted-by":"publisher","first-page":"361","DOI":"10.3181\/00379727-93-22757","article-title":"Effect of methotrexate therapy upon choriocarcinoma and chorioadenoma.","volume":"93","author":"Li","year":"1956"},{"key":"b14","series-title":"Arch Surg","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1001\/archsurg.1966.01330020134023","article-title":"Germinal neoplasms of the central nervous system.","volume":"93","author":"Nishiyama","year":"1966"},{"key":"b15","series-title":"Acta Pathol Jpn","first-page":"841","article-title":"Three autopsy cases of testicular and intracranial choriocarcinoma in the male.","volume":"6","author":"Nishizuka","year":"1956"},{"key":"b16","series-title":"Am J Obstet Gynecol","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/0002-9378(65)90661-7","article-title":"Sequential use of methotrexate and actinomycin D in the treatment of metastatic choriocarcinoma and related trophoblastic diseases in women.","volume":"93","author":"Ross","year":"1965"},{"key":"b17","series-title":"Cancer Res","first-page":"1015","article-title":"Actinomycin D in the treatment of methotrexate-resistant trophoblastic disease in women.","volume":"22","author":"Ross","year":"1962"},{"key":"b18","series-title":"J Pathol Bacteriol","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1002\/path.1700560202","article-title":"The pinealoma. Its relationship to teratoma.","volume":"56","author":"Russell","year":"1944"},{"key":"b19","series-title":"JAMA","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1001\/jama.1972.03200160028008","article-title":"Cure of metastatic choriocarcinoma of the brain.","volume":"221","author":"Stilp","year":"1972"},{"key":"b20","series-title":"Am J Pathol","first-page":"787","article-title":"Primary intracranial chorionepithelioma with metastases to the lungs.","volume":"21","author":"Stowell","year":"1945"},{"key":"b21","series-title":"Surg Neurol","first-page":"247","article-title":"Teratomas in the suprasellar region. Report of five cases.","volume":"3","author":"Tekeuchi","year":"1975"},{"key":"b22","series-title":"J Endocrinol","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1677\/joe.0.0100012","article-title":"Precocious puberty and chorioepithelioma of the pineal gland with report of a case.","volume":"10","author":"Zondek","year":"1953"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/53\/3\/article-p369.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/53\/3\/article-p369.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/53\/3\/article-p369.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T06:40:34Z","timestamp":1658731234000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/53\/3\/article-p369.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,9]]},"references-count":22,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3171\/jns.1980.53.3.0369","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[1980,9]]}}}