{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:24:12Z","timestamp":1760189052841},"reference-count":34,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1980,11]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 The effects of acute hypertension and respiratory stress induced by Aramine (metaraminol bitartrate) upon blood-brain barrier (BBB) permeability to horseradish peroxidase (HRP) were studied in adult inbred white rats. The BBB permeability was quantitated by slicing the brain of each animal into 500-\u00b5 thick sections, incubating the sections using the Reese-Karnovsky method, and counting all observed HRP perivascular exudates. No evidence of BBB compromise or significant elevation of blood pressure (BP) was observed in the following experimental groups: 1) control group of five animals; 2) hyperventilated group of five animals (final mean arterial blood gases: pO<jats:sub>2<\/jats:sub>, 104.2 mm Hg; pCO<jats:sub>2<\/jats:sub>, 24.8 mm Hg; pH, 7.53); 3) anoxicstress group of five animals (final mean arterial blood gases: pCO<jats:sub>2<\/jats:sub>, 31.4 mm Hg; pCO<jats:sub>2<\/jats:sub>, 58.2 mm Hg; pH, 7.21). However, in a group of 15 animals subjected to anoxic stress followed by hyperventilation, in addition to extreme changes in the levels of arterial blood gases, a significant BP increase occurred (mean BP increase per second, 3.43 \u00b1 0.25 mm Hg; final mean BP, 163.3 \u00b1 3.18 mm Hg); as well as significant BBB opening (mean number of HRP exudates per animal, 12.2 \u00b1 0.85). Likewise, a final group of 10 animals given intravenous Aramine displayed a significant systemic BP elevation (mean BP increase per second, 6.9 \u00b1 0.38 mm Hg; final mean BP, 165.8 \u00b1 3.16 mm Hg), accompanied by BBB opening (mean number of exudates per animal, 51.5 \u00b1 5.95). The variable most strongly associated with the degree of barrier opening was the rate of BP rise (correlation coefficient = + 0.84).<\/jats:p>","DOI":"10.3171\/jns.1980.53.5.0666","type":"journal-article","created":{"date-parts":[[2009,5,7]],"date-time":"2009-05-07T15:40:18Z","timestamp":1241710818000},"page":"666-673","source":"Crossref","is-referenced-by-count":7,"title":["Influence of respiratory stress and hypertension upon the blood-brain barrier"],"prefix":"10.3171","volume":"53","author":[{"given":"Joe Sam","family":"Robinson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Moody","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Appl Physiol","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1152\/jappl.1967.23.5.726","article-title":"Cerebral cortical blood flow during changes of acid-base equilibrium of the brain.","volume":"23","author":"Betz","year":"1967"},{"key":"b2","series-title":"J Comp Neurol","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1002\/cne.901520402","article-title":"Osmotic opening of tight junctions in cerebral endothelium.","volume":"152","author":"Brightman","year":"1973"},{"key":"b3","series-title":"Lancet","first-page":"201","article-title":"The pathogenesis of hypertensive encephalopathy and its relation to the malignant phase of hypertension. 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