{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:34:38Z","timestamp":1759484078208},"reference-count":11,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1980,11]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Myoglobinuria developed in a patient with subarachnoid hemorrhage treated with a course of 1.43 kg of epsilon-aminocaproic acid (EACA) given over 41 days. Review of eight other cases with a variety of medical disorders shows that this effect occurs after at least 4 weeks of taking doses of a minimum of 24 gm EACA per day. The effect seems to be reversible if discovered early. This side-effect should provide impetus for restricting the duration of EACA therapy to periods under 28 days, in doses no higher than 24 gm\/day.<\/jats:p>","DOI":"10.3171\/jns.1980.53.5.0690","type":"journal-article","created":{"date-parts":[[2009,5,7]],"date-time":"2009-05-07T15:40:18Z","timestamp":1241710818000},"page":"690-692","source":"Crossref","is-referenced-by-count":20,"title":["Myoglobinuria following epsilon-aminocaproic acid (EACA) therapy"],"prefix":"10.3171","volume":"53","author":[{"given":"Henry M.","family":"Brodkin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Postgrad Med J","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1136\/pgmj.48.561.440","article-title":"Myopathy from \u03b5-aminocaproic acid: a second case.","volume":"48","author":"Bennett","year":"1972"},{"issue":"6","key":"b2","series-title":"Med Clin North Am","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1016\/S0025-7125(16)33112-1","article-title":"The complications of therapy with epsilonaminocaproic acid.","volume":"50","author":"Bergin","year":"1966"},{"key":"b3","series-title":"Lancet","first-page":"741","article-title":"Prevention of early recurrence of spontaneous subarachnoid haemorrhage by \u03b5-aminocaproic acid.","volume":"1","author":"Chowdhary","year":"1979"},{"key":"b4","series-title":"N Engl J Med","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1056\/NEJM197204132861503","article-title":"Epsilon aminocaproic acid therapy of hereditary angioneurotic edema. A double-blind study.","volume":"286","author":"Frank","year":"1972"},{"key":"b5","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"499","DOI":"10.3171\/jns.1974.40.4.0499","article-title":"Streptokinase clot lysis time in patients with ruptured intracranial aneurysms.","volume":"40","author":"Geronemus","year":"1974"},{"key":"b6","series-title":"Acta Med Scand","first-page":"341","article-title":"Extensive muscle necrosis after long-term treatment with aminocaproic acid (EACA) in a case of hereditary periodic edema.","volume":"185","author":"Korsan-Bengsten","year":"1969"},{"key":"b7","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"597","DOI":"10.3171\/jns.1978.49.4.0597","article-title":"Myopathy associated with epsilon-aminocaproic acid (EACA) therapy: report of two cases.","volume":"49","author":"MacKay","year":"1978"},{"key":"b8","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1161\/01.STR.6.6.622","article-title":"Intracranial aneurysms and subarachnoid hemorrhage. A cooperative study. Antifibrinolytic therapy in recent onset subarachnoid hemorrhage.","volume":"6","author":"Nibbelink","year":"1975"},{"key":"b9","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"290","DOI":"10.3171\/jns.1977.46.3.0290","article-title":"Ruptured intracranial aneurysms. Case morbidity and mortality.","volume":"46","author":"Post","year":"1977"},{"key":"b10","series-title":"JAMA","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.1001\/jama.1976.03270170011010","article-title":"Myoglobinuria following aminocaproic acid administration.","volume":"236","author":"Rizza","year":"1976"},{"key":"b11","series-title":"Lancet","first-page":"847","article-title":"Epsilon aminocaproic acid and subarachnoid hemorrhage.","volume":"2","author":"Shaw","year":"1974"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/53\/5\/article-p690.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/53\/5\/article-p690.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/53\/5\/article-p690.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T09:37:22Z","timestamp":1658741842000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/53\/5\/article-p690.xml"}},"subtitle":["Case report"],"short-title":[],"issued":{"date-parts":[[1980,11]]},"references-count":11,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.3171\/jns.1980.53.5.0690","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[1980,11]]}}}