{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:59:19Z","timestamp":1787169559675,"version":"build-2736575974"},"reference-count":34,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1981,1]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 The neurological and neuroradiological manifestations of pediatric achondroplasia are analyzed on the basis of 10 cases. In addition to the classical symptomatology of an enlarging head, with or without increased intracranial pressure, several patients presented symptoms related to a small foramen magnum. Respiratory problems and quadriparesis were also observed in these patients. Six patients who were treated by foramen magnum decompression showed remarkable improvement. Neuroradiological evaluation revealed a significant number of patients with dilated cortical sulci and basal cisterns, and mild dilatation of the ventricles on computerized tomography (CT) and\/or ventriculography. Two patients showed signs of obstruction at the fourth ventricle outlets. Some exhibited anomalous dilatation of cerebral veins and dural sinuses, narrowing of the sinuses at the jugular foramen, and enlarged emissary veins. Ventriculoperitoneal or ventriculoatrial shunts were placed in three patients. In the other children with a large head and dilated ventricles, head growth curves paralleled the normal slope, and there was no significant clinical evidence of increased intracranial pressure or enlarging ventricles on follow-up CT scan.<\/jats:p>","DOI":"10.3171\/jns.1981.54.1.0049","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T09:55:57Z","timestamp":1241776557000},"page":"49-57","source":"Crossref","is-referenced-by-count":79,"title":["Neurological manifestations of pediatric achondroplasia"],"prefix":"10.3171","volume":"54","author":[{"given":"Hiroshi","family":"Yamada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigetoshi","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Tajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Kageyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Acta Neurol Scand","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/j.1600-0404.1971.tb07464.x","article-title":"Neurological symptoms in achondroplasia.","volume":"47","author":"Bergstr\u00f6m","year":"1971"},{"key":"b2","series-title":"Arch Neurol Psychiatry","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1001\/archneurpsyc.1959.02340180027004","article-title":"Production of hydrocephalus by increased cephalic-venous pressure.","volume":"81","author":"Bering","year":"1959"},{"key":"b3","series-title":"J Pediatr","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/S0022-3476(67)80296-8","article-title":"Neurological abnormalities in achondroplastic children.","volume":"71","author":"Cohen","year":"1967"},{"key":"b4","series-title":"Am J Obstet Gynecol","first-page":"1346","article-title":"Identical hydrocephalic achondroplastic twins; subsequent delivery of single sibling with same abnormalities.","volume":"7","author":"Cohn","year":"1956"},{"key":"b5","series-title":"Bull Johns Hopkins Hosp","first-page":"5","article-title":"Hydrocephalus in chondrodystrophy.","volume":"32","author":"Dandy","year":"1921"},{"key":"b6","series-title":"Dev Med Child Neurol","first-page":"28","article-title":"Hydrocephalus associated with raised venous pressure.","volume":"12","author":"de Lange","year":"1970"},{"key":"b7","series-title":"Brain","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1093\/brain\/84.3.427","article-title":"Megalencephaly, internal hydrocephalus and other neurological aspects of achondroplasia.","volume":"84","author":"Dennis","year":"1961"},{"key":"b8","series-title":"Dev Med Child Neurol","first-page":"224","article-title":"CSF scanning in achondroplastic children with cranial enlargement.","volume":"17","author":"Depresseux","year":"1975"},{"key":"b9","series-title":"Arch Dis Child","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1136\/adc.31.158.288","article-title":"Hydrocephalus associated with obliteration of the longitudinal sinus.","volume":"31","author":"Emery","year":"1956"},{"key":"b10","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1212\/WNL.5.12.875","article-title":"Compression of spinal cord and cauda equina in achondroplastic dwarfs.","volume":"5","author":"Epstein","year":"1955"},{"key":"b11","series-title":"Neuroradiology","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/BF00345272","article-title":"Neurological complications and myelographic features of achondroplasia.","volume":"17","author":"Galanski","year":"1978"},{"key":"b12","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"597","DOI":"10.3171\/jns.1975.42.5.0597","article-title":"Hydrocephalus resulting from superior vena cava thrombosis in an infant. Case report.","volume":"42","author":"Haar","year":"1975"},{"key":"b13","series-title":"Paraplegia","first-page":"23","article-title":"Spinal compression in achondroplasia.","volume":"3","author":"Hancock","year":"1965"},{"key":"b14","series-title":"Pediatrics","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1542\/peds.28.5.792","article-title":"Hydrocephalus and obstruction of the superior vena cava in infancy.","volume":"28","author":"Hooper","year":"1961"},{"key":"b15","series-title":"Pediatrics","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1542\/peds.49.1.46","article-title":"Hydrocephalus in achondroplasia studied by cisternography.","volume":"49","author":"James","year":"1972"},{"key":"b16","series-title":"J Anat","first-page":"360","article-title":"The causation of the condition known as achondroplasia.","volume":"47","author":"Jansen","year":"1912"},{"key":"b17","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"195","DOI":"10.3171\/jns.1962.19.3.0195","article-title":"Hydrocephalus and the dural venous sinuses.","volume":"19","author":"Kinal","year":"1962"},{"key":"b18","series-title":"Am J Roentgenol","doi-asserted-by":"publisher","first-page":"12","DOI":"10.2214\/ajr.100.1.12","article-title":"Achondroplasia.","volume":"100","author":"Langer","year":"1967"},{"key":"b19","series-title":"J Bone Joint Surg (Am)","doi-asserted-by":"publisher","first-page":"87","DOI":"10.2106\/00004623-197759010-00016","article-title":"Neurological symptoms in achondroplastic dwarfs \u2014 surgical treatment.","volume":"59","author":"Lutter","year":"1977"},{"key":"b20","series-title":"Acta Neurochir","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/BF01809153","article-title":"Basilar impression in an achondroplastic dwarf: causative role in tetraparesis.","volume":"41","author":"Luyendijk","year":"1978"},{"key":"b21","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"673","DOI":"10.3171\/jns.1969.30.6.0673","article-title":"Evaluation of photoscanning of the diffusion of intrathecal RISA in infantile and childhood hydrocephalus.","volume":"30","author":"McCullough","year":"1969"},{"key":"b22","series-title":"Hydrocephalus and the Cerebrospinal Fluid.","first-page":"46","author":"Milhorat","year":"1972"},{"key":"b23","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1212\/WNL.27.5.430","article-title":"Achondroplasia and hydrocephalus.","volume":"27","author":"Mueller","year":"1977"},{"key":"b24","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"561","DOI":"10.3171\/jns.1969.31.5.0561","article-title":"Venous factors in infantile hydrocephalus.","volume":"31","author":"Norrell","year":"1969"},{"key":"b25","series-title":"Arch Neurol","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1001\/archneur.1978.00500290052009","article-title":"Megalencephaly in infants and children. The possible role of increased dural sinus pressure.","volume":"35","author":"Portnoy","year":"1978"},{"key":"b26","series-title":"Pathology of the Fetus and the Infant","first-page":"550","author":"Potter","year":"1975"},{"key":"b27","series-title":"Ann Neurol","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1002\/ana.410030516","article-title":"Hydrocephalus caused by increased intracranial venous pressure: a clinicopathological study.","volume":"3","author":"Rosman","year":"1978"},{"key":"b28","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"169","DOI":"10.3171\/jns.1965.23.2.0169","article-title":"Sagittal sinus venous pressure in hydrocephalus.","volume":"23","author":"Shulman","year":"1965"},{"key":"b29","series-title":"J Neurol Neurosurg Psychiatry","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1136\/jnnp.15.4.246","article-title":"Three cases of achondroplasia with neurological complications.","volume":"15","author":"Spillane","year":"1952"},{"key":"b30","series-title":"J Pediatr Surg","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/0022-3468(75)90383-8","article-title":"Hydrocephalus as a complication of jugular catheterization during total parenteral nutrition.","volume":"10","author":"Stewart","year":"1975"},{"key":"b31","series-title":"Arch Neurol Psychiatry","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1001\/archneurpsyc.1949.02310120048003","article-title":"Lesions of the spinal cord (transverse myelopathy) in achondroplasia.","volume":"61","author":"Vogl","year":"1949"},{"key":"b32","series-title":"Congenital Malformations.","first-page":"768","author":"Warkany","year":"1971"},{"key":"b33","series-title":"Beitr Pathol Anat Pathol","first-page":"1","article-title":"Zur Frage des Hydrocephalus chondrodystrophicus congenitus.","volume":"97","author":"Welter","year":"1936"},{"key":"b34","series-title":"Neuropaediatrie","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1055\/s-0028-1091803","article-title":"Achondroplasia and hydrocephalus.","volume":"3","author":"Wise","year":"1971"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/54\/1\/article-p49.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/54\/1\/article-p49.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/54\/1\/article-p49.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,19]],"date-time":"2023-03-19T16:24:32Z","timestamp":1679243072000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/54\/1\/article-p49.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,1]]},"references-count":34,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3171\/jns.1981.54.1.0049","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[1981,1]]}}}