{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:02:11Z","timestamp":1761058931279},"reference-count":14,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1981,4]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 The authors have analyzed the effect of pentobarbital (10<jats:sup>\u22125<\/jats:sup>M to 10<jats:sup>\u22123<\/jats:sup>M) on the contractile activity of isolated human cerebral arteries. Pentobarbital was found to inhibit both the spontaneous mechanical activity and the basal tone of these vessels. Relaxation induced by this drug was dose-dependent, and was more marked when the arterial tone was previously increased with noradrenalin, potassium chloride, or 5-hydroxytryptamine. In addition, pentobarbital inhibits, in a dose-dependent manner, the contractions elicited by these vasoconstrictor agents. The present findings indicate that barbiturates decrease cerebrovascular reactivity, and disagree with the hypothesis that these drugs reduce raised intracranial pressure by means of exerting a direct constrictive effect on the cerebral arteries.<\/jats:p>","DOI":"10.3171\/jns.1981.54.4.0521","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T13:57:10Z","timestamp":1241791030000},"page":"521-524","source":"Crossref","is-referenced-by-count":27,"title":["Effect of pentobarbital on the reactivity of isolated human cerebral arteries"],"prefix":"10.3171","volume":"54","author":[{"given":"Jes\u00fas","family":"Mar\u00edn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramiro D.","family":"Lobato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mercedes L.","family":"Rico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mercedes","family":"Salaices","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"Benitez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Am J Physiol","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1152\/ajplegacy.1975.229.6.1635","article-title":"Pentobarbital and contraction of vascular smooth muscle.","volume":"229","author":"Altura","year":"1975"},{"key":"b2","series-title":"J Pharmacol Exp Ther","first-page":"80","article-title":"Barbiturates block calcium uptake by stimulated and potassium-depolarized rat sympathetic ganglia.","volume":"196","author":"Blaustein","year":"1976"},{"key":"b3","series-title":"Physiol Rev","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1152\/physrev.1979.59.3.606","article-title":"Mechanisms of action of transmitters and other substances on smooth muscle.","volume":"59","author":"Bolton","year":"1979"},{"key":"b4","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1161\/01.STR.9.1.12","article-title":"Dose dependent reduction of glucose utilization by pentobarbital in rat brain.","volume":"9","author":"Crane","year":"1978"},{"key":"b5","series-title":"The Release of Catecholamines from Adrenergic Neurons.","first-page":"241","article-title":"Modification of catecholamine release by anaesthetics and alcohols","author":"G\u00f6ther","year":"1978"},{"key":"b6","series-title":"Intracranial Pressure IV.","first-page":"669","article-title":"Closing discussion","author":"Langfitt","year":"1980"},{"key":"b7","series-title":"J Pharmacol Exp Ther","first-page":"166","article-title":"Inhibition by pentobarbital of the acetylcholine release from the postganglionic parasympathetic neuron of the heart.","volume":"210","author":"Lindmar","year":"1979"},{"key":"b8","series-title":"Anesthesiology","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1097\/00000542-197708000-00006","article-title":"Neurosurgical intensive care.","volume":"47","author":"Marsh","year":"1977"},{"key":"b9","series-title":"Crit Care Med","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00003246-197801000-00001","article-title":"Pentobarbital therapy for intracranial hypertension in metabolic coma: Reye's syndrome.","volume":"6","author":"Marshall","year":"1978"},{"key":"b10","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3171\/jns.1979.50.1.0020","article-title":"The outcome with aggressive treatment in severe head injuries. 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