{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T22:26:36Z","timestamp":1747779996052},"reference-count":25,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1981,5]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 In 13 dogs the response of the cerebral circulation to changes in PaCO<jats:sub>2<\/jats:sub> ranging from 20 to 60 torr was studied before and after administration of high doses of sodium thiopental. Infusion of sufficient barbiturate to produce 30- to 60-second burst suppression in the electroencephalogram was associated with a profound degree of cerebral vasoconstriction, equivalent to that produced by hypocapnia with PaCO<jats:sub>2<\/jats:sub> = 20 torr. Furthermore, once sodium thiopental was administered, no significant difference in cerebral blood flow (CBF) or vascular resistance (CVR) was noted between PaCO<jats:sub>2<\/jats:sub> of 30 and 20 torr. However, changes of approximately 15% in CBF and 30% in CVR were noted between PaCO<jats:sub>2<\/jats:sub> at 40 and 20 torr. These data suggest that hyperventilation of PaCO<jats:sub>2<\/jats:sub> of less than 30 torr may not effectively increase the degree of cerebral vasoconstriction in these circumstances.<\/jats:p>","DOI":"10.3171\/jns.1981.54.5.0615","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T13:55:24Z","timestamp":1241790924000},"page":"615-619","source":"Crossref","is-referenced-by-count":17,"title":["Influence of changes in arterial pCO2 on cerebral blood flow and metabolism during high-dose barbiturate therapy in dogs"],"prefix":"10.3171","volume":"54","author":[{"given":"Neal F.","family":"Kassell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick W.","family":"Hitchon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary K.","family":"Gerk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin D.","family":"Sokoll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd R.","family":"Hill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Appl Physiol","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1152\/jappl.1968.24.1.66","article-title":"Cerebral carbohydrate metabolism of man during respiratory and metabolic alkalosis.","volume":"24","author":"Alexander","year":"1968"},{"key":"b2","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1161\/01.STR.10.6.647","article-title":"Barbiturates in focal ischemia of primate cortex: effects on blood flow distribution, evoked potential and extracellular potassium.","volume":"10","author":"Branston","year":"1979"},{"key":"b3","series-title":"J Appl Physiol","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1152\/jappl.1971.31.4.598","article-title":"Some sources of error in measuring regional blood flow with radioactive microspheres.","volume":"31","author":"Buckberg","year":"1971"},{"key":"b4","series-title":"Acta Neurochir Scand Suppl","first-page":"152","article-title":"Antioxidant effects of barbiturates in model membranes undergoing free radical damage.","volume":"64","author":"Demopoulos","year":"1977"},{"key":"b5","series-title":"Acta Neurochir Scand Suppl","first-page":"150","article-title":"Possible molecular mechanisms of barbiturate-mediated protection in regional cerebral ischemia.","volume":"64","author":"Flamm","year":"1977"},{"key":"b6","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"65","DOI":"10.3171\/jns.1962.19.1.0065","article-title":"The achievement of optimal brain relaxation by hyperventilation technics of anesthesia.","volume":"19","author":"Hayes","year":"1962"},{"key":"b7","series-title":"Prog Cardiovasc Dis","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/S0033-0620(77)80005-4","article-title":"Blood flow measurements with radionuclide-labeled particles.","volume":"20","author":"Heymann","year":"1977"},{"key":"b8","series-title":"Acta Neurochir Scand Suppl","first-page":"158","article-title":"Barbiturates for protection from cerebral ischemia in aneurysm surgery.","volume":"64","author":"Hoff","year":"1977"},{"key":"b9","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1227\/00006123-198012000-00011","article-title":"Alterations in cerebral blood flow, oxygen metabolism, and electrical activity produced by high dose sodium thiopental.","volume":"7","author":"Kassell","year":"1980"},{"key":"b10","series-title":"J Clin Invest","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1172\/JCI101995","article-title":"The effects of altered arterial tensions of carbon dioxide and oxygen on cerebral blood flow and cerebral oxygen consumption of normal young men.","volume":"27","author":"Kety","year":"1948"},{"key":"b11","series-title":"Anesthesiology","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1097\/00000542-197809000-00002","article-title":"Cerebral hypometabolism obtained with deep pentobarbital anesthesia and hypothermia (30\u00b0C).","volume":"49","author":"Lafferty","year":"1978"},{"key":"b12","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"975","DOI":"10.3171\/jns.1966.24.6.0975","article-title":"Acute brain swelling in neurosurgical patients.","volume":"24","author":"Langfitt","year":"1966"},{"key":"b13","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"710","DOI":"10.3171\/jns.1979.51.5.0710","article-title":"Treatment of intraoperative middle cerebral artery occlusion with pentobarbital and extracranial-intracranial bypass. 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