{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T22:39:26Z","timestamp":1776724766472,"version":"3.51.2"},"reference-count":13,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1981,6]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Pituitary abscess is an unusual cause of sella turcica enlargement. Because its presentation closely mimics that of a pituitary tumor, the condition is seldom recognized preoperatively. Most cases have been of bacterial etiology; however, a single patient with a primary mycotic pituitary abscess secondary to <jats:italic>Aspergillus<\/jats:italic> species has been reported. That patient died of diffuse <jats:italic>Aspergillus<\/jats:italic> meningoencephalitis following a transfrontal craniotomy. In the present case, a woman with primary pituitary aspergillosis survived her infection with virtually intact pituitary function following a transsphenoidal approach which avoided contamination of cerebrospinal fluid. Postoperative amphotericin-B and 5-fluorocytosine therapy probably contributed greatly to her survival. Factors that should alert the clinician to the presence of a pituitary abscess in a patient with sella turcica enlargement are prior episodes of meningitis, sinusitis, or cerebrospinal fluid abnormalities, including pleocytosis, depressed glucose, and elevated protein.<\/jats:p>","DOI":"10.3171\/jns.1981.54.6.0839","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T13:45:35Z","timestamp":1241790335000},"page":"839-841","source":"Crossref","is-referenced-by-count":56,"title":["Primary pituitary aspergillosis responding to transsphenoidal surgery and combined therapy with amphotericin-B and 5-fluorocytosine"],"prefix":"10.3171","volume":"54","author":[{"given":"Angelita","family":"Ramos-Gabatin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard M.","family":"Jordan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Neurochirurgia","first-page":"34","article-title":"Intrasellar abscess simulating pituitary adenoma.","volume":"14","author":"Askenazy","year":"1971"},{"key":"b2","series-title":"Am J Med","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/0002-9343(73)90207-6","article-title":"5-fluorocytosine treatment of meningeal and pulmonary aspergillosis.","volume":"55","author":"Atkinson","year":"1973"},{"key":"b3","series-title":"JAMA","doi-asserted-by":"publisher","first-page":"2418","DOI":"10.1001\/jama.1979.03290480052025","article-title":"Combined amphotericin B-5-fluorocytosine therapy in Aspergillus pneumonia.","volume":"241","author":"Codish","year":"1979"},{"key":"b4","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"601","DOI":"10.3171\/jns.1977.46.5.0601","article-title":"Pituitary abscesses. Report of seven cases and review of the literature.","volume":"46","author":"Domingue","year":"1977"},{"key":"b5","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"530","DOI":"10.3171\/jns.1977.46.4.0530","article-title":"Aspergillus infection complicating transsphenoidal yttrium-90 pituitary implant. Report of two cases.","volume":"46","author":"Feely","year":"1977"},{"key":"b6","series-title":"Trans Am Ophthalmol Soc","first-page":"65","article-title":"Mycotic intrasellar abscess.","volume":"72","author":"Goldhammer","year":"1974"},{"key":"b7","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"616","DOI":"10.3171\/jns.1973.38.5.0616","article-title":"Intrasellar or pituitary abscess.","volume":"38","author":"Lindholm","year":"1973"},{"key":"b8","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"359","DOI":"10.3171\/jns.1972.36.3.0359","article-title":"Abscess formation in a Rathke's cleft cyst. Case report.","volume":"36","author":"Obenchain","year":"1972"},{"key":"b9","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"785","DOI":"10.3171\/jns.1972.36.6.0785","article-title":"Pituitary abscess in a craniopharyngioma. 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Successful therapy after failure with amphotericin B and surgery.","volume":"244","author":"Yu","year":"1980"},{"key":"b13","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1227\/00006123-197912000-00014","article-title":"Invasive pituitary adenoma with abscess formation. Case report.","volume":"5","author":"Zorub","year":"1979"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/54\/6\/article-p839.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/54\/6\/article-p839.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/54\/6\/article-p839.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,19]],"date-time":"2023-03-19T20:25:56Z","timestamp":1679257556000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/54\/6\/article-p839.xml"}},"subtitle":["Case report"],"short-title":[],"issued":{"date-parts":[[1981,6]]},"references-count":13,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.3171\/jns.1981.54.6.0839","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[1981,6]]}}}