{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T21:53:48Z","timestamp":1776376428363,"version":"3.51.2"},"reference-count":13,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1981,11]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Transient reversible osmotic blood-brain barrier disruption was produced in the posterior fossa of 33 dogs. A percutaneous catheter technique was used for the infusion of hypertonic mannitol into the vertebral artery. Neither the catheter technique nor the osmotic barrier modification resulted in interference with brain-stem function in most animals. The degree of barrier modification achieved by osmotic disruption in the posterior fossa is similar to that previously described for barrier modification of the supratentorial parenchyma. Methotrexate delivered to the brain via the vertebral artery resulted in a drug concentration of 100 to 300 ng\/gm brain tissue. When the same amount of drug was given following osmotic blood-brain barrier disruption, brain tissue contained 1100 to 5000 ng of methotrexate\/gm of brain tissue. Finally, the adequacy of the blood-brain barrier modification in the posterior fossa was shown to be quantifiable by the amount of enhancement on computerized tomographic scans.<\/jats:p>","DOI":"10.3171\/jns.1981.55.5.0742","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T13:47:55Z","timestamp":1241790475000},"page":"742-748","source":"Crossref","is-referenced-by-count":54,"title":["Osmotic blood-brain barrier disruption in the posterior fossa of the dog"],"prefix":"10.3171","volume":"55","author":[{"given":"Edward A.","family":"Neuwelt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Glasberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Diehl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene P.","family":"Frenkel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peggy","family":"Barnett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Proc Natl Acad Sci USA","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1073\/pnas.76.1.481","article-title":"Modification of the blood-brain barrier: increased concentration and fate of enzymes entering the brain.","volume":"76","author":"Barranger","year":"1979"},{"key":"b2","series-title":"Anatomy of the Dog","first-page":"316","author":"Miller","year":"1964"},{"key":"b3","series-title":"Ann Intern Med","doi-asserted-by":"publisher","first-page":"449","DOI":"10.7326\/0003-4819-94-4-449","article-title":"Monitoring of methotrexate delivery in patients with malignant brain tumors after osmotic blood-brain barrier disruption.","volume":"94","author":"Neuwelt","year":"1981"},{"key":"b4","series-title":"Ann Intern Med","doi-asserted-by":"publisher","first-page":"137","DOI":"10.7326\/0003-4819-93-1-137","article-title":"Is there a therapeutic role for blood-brain barrier disruption?","volume":"93","author":"Neuwelt","year":"1980"},{"key":"b5","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1227\/00006123-198007000-00007","article-title":"Reversible osmotic blood-brain barrier disruption in humans: implications for the chemotherapy of malignant brain tumors.","volume":"7","author":"Neuwelt","year":"1980"},{"key":"b6","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1227\/00006123-198007000-00006","article-title":"Effect of osmotic blood-brain barrier disruption on methotrexate pharmacokinetics in the dog.","volume":"7","author":"Neuwelt","year":"1980"},{"key":"b7","series-title":"J Clin Invest","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1172\/JCI109509","article-title":"Osmotic blood-brain barrier disruption. Computerized tomographic monitoring of chemotherapeutic agent delivery.","volume":"64","author":"Neuwelt","year":"1979"},{"key":"b8","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1227\/00006123-198001000-00007","article-title":"Use of enhanced computerized tomography to evaluate osmotic blood-brain barrier disruption.","volume":"6","author":"Neuwelt","year":"1980"},{"key":"b9","series-title":"Ann Neurol","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1002\/ana.410050302","article-title":"Osmotic opening of the blood-brain barrier and local cerebral glucose utilization.","volume":"5","author":"Pappius","year":"1979"},{"key":"b10","series-title":"Blood-Brain Barrier in Physiology and Medicine","author":"Rapoport","year":"1976"},{"key":"b11","series-title":"Science","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1126\/science.176.4040.1243","article-title":"Chronic effects of osmotic opening of the blood-brain barrier in the monkey.","volume":"176","author":"Rapoport","year":"1972"},{"key":"b12","series-title":"Brain Res","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/0006-8993(77)90128-7","article-title":"Osmotic opening of the blood-brain barrier in the rhesus monkey without measurable brain edema.","volume":"136","author":"Rapoport","year":"1977"},{"key":"b13","series-title":"Acta Radiol","doi-asserted-by":"publisher","first-page":"368","DOI":"10.3109\/00016925309136722","article-title":"Catheter replacement of the needle in percutaneous arteriography. A new technique.","volume":"39","author":"Seldinger","year":"1953"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/55\/5\/article-p742.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/55\/5\/article-p742.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/55\/5\/article-p742.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,24]],"date-time":"2022-07-24T11:58:45Z","timestamp":1658663925000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/55\/5\/article-p742.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,11]]},"references-count":13,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.3171\/jns.1981.55.5.0742","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[1981,11]]}}}