{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T12:37:28Z","timestamp":1726058248564},"reference-count":51,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1981,11]]},"abstract":"\u2713 Transformation of arachidonic acid into prostaglandins was investigated in the basilar artery by incubating sections of artery with carbon-14-labeled arachidonic acid. Thin-layer radiochromatography revealed that, in normal canine basilar arteries, 14C-arachidonic acid was transformed mainly to 6-ketoprostaglandin (PG)F1\u03b1<\/jats:sub>, a spontaneous metabolite of prostacyclin (PGI2<\/jats:sub>). Among other prostaglandins, only a small amount of PGF2\u03b1<\/jats:sub> was detected, whereas PGD2<\/jats:sub>, PGE2<\/jats:sub>, and thromboxane B2<\/jats:sub> were not. Arteries removed on Days 3 and 8 after subarachnoid blood injection showed a prostaglandin synthesis profile similar to that in the normal cerebral artery.<\/jats:p>\nIn borate-buffered saline (0.1M borate buffer, pH 9.0\/0.15M NaCl = 1:9, vol\/vol), canine basilar artery produced a PGI2<\/jats:sub>-like substance that inhibited adenosine diphosphate (ADP)-induced platelet aggregation. Its anti-aggregatory activity was completely abolished by acidification. Aspirin likewise inhibited production of the anti-aggregatory substance. From these results, it was concluded that the anti-aggregatory activity was due solely to the production of PGI2<\/jats:sub> by the arterial specimen. Based on the above results, PGI2<\/jats:sub> biosynthetic activity in the cerebral artery exposed to subarachnoid blood injection was bioassayed by measuring the inhibitory activity of the incubation product upon ADP-induced platelet aggregation following incubation of the arteries in borate-buffered saline for 5 to 30 minutes at 20\u00b0C, using synthetic PGI2<\/jats:sub>-Na as a standard.<\/jats:p>\nThe synthetic activity of PGI2<\/jats:sub> in the artery exposed to subarachnoid blood injection had diminished remarkably by Days 3 and 8. This diminution of PGI2<\/jats:sub> synthesis in the cerebral artery may be involved in the pathogenesis of cerebral vasospasm.<\/jats:p>","DOI":"10.3171\/jns.1981.55.5.0771","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T13:47:55Z","timestamp":1241790475000},"page":"771-778","source":"Crossref","is-referenced-by-count":82,"title":["Evaluation of prostaglandin biosynthetic activity in canine basilar artery following subarachnoid injection of blood"],"prefix":"10.3171","volume":"55","author":[{"given":"Tomio","family":"Sasaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sei-itsu","family":"Murota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Wakai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Asano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Sano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Neurochem","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1111\/j.1471-4159.1980.tb09980.x","article-title":"Prostaglandin profiles in tissue and blood vessels from human brain.","volume":"34","author":"Abdel-Halim","year":"1980"},{"key":"b2","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"594","DOI":"10.3171\/jns.1976.44.5.0594","article-title":"Cerebral arterial spasm. 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