{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T23:00:49Z","timestamp":1715554849882},"reference-count":26,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1982,3]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Experiments were performed to determine the effects of fibrin-fibrinogen degradation products on the human basilar artery <jats:italic>in vitro<\/jats:italic>. Citrated plasma and streptokinase were incubated at 37\u00b0C to produce a preparation of fibrinogen degradation products. Aliquots of the incubate were obtained at 90 minutes, 48 hours, and 1 and 2 weeks after preparation, and were separated into fractions of different molecular weight (MWt), using an ultrafiltration technique. Each fraction was tested at each of the above times for contractile activity and possible interaction with a threshold concentration of 5-hydroxytryptamine (5-HT) on the human basilar artery. Contractile activity was initially confined to the 90-minute aliquot fraction MWt &gt; 100,000, but as the incubation proceeded, such activity was also seen in the lower MWt fraction &lt; 100,000 &gt; 10,000 at all time intervals. This activity was never seen in the fraction MWt &lt; 10,000 at any time. Enhancement of the 5-HT response was initially confined to the higher molecular weight fractions, but after 48-hour incubation all fractions showed this activity. It is suggested that products of fibrin-fibrinogen degradation may be involved directly or indirectly in influencing the pathophysiological mechanism(s) responsible for cerebral arterial spasm following subarachnoid hemorrhage.<\/jats:p>","DOI":"10.3171\/jns.1982.56.3.0339","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T16:20:46Z","timestamp":1241799646000},"page":"339-343","source":"Crossref","is-referenced-by-count":12,"title":["Effect of fibrin-fibrinogen degradation products on human basilar artery preparations"],"prefix":"10.3171","volume":"56","author":[{"given":"Richard H.","family":"Lye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamal S.","family":"Paul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine M.","family":"Forster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric T.","family":"Whalley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Dutton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"451","DOI":"10.3171\/jns.1974.40.4.0451","article-title":"Cerebral arterial spasm. Part 3: In vivo intracisternal production of spasm by serotonin and blood and its reversal by phenoxybenzamine.","volume":"40","author":"Allen","year":"1974"},{"key":"b2","series-title":"Cerebral Arterial Spasm.","first-page":"144","article-title":"The relationship of vasoactive substances in CSF of subarachnoid patients to cerebral vasospasm and prognosis","author":"Blaso","year":"1980"},{"key":"b3","series-title":"Cerebral Vasospasm.","first-page":"241","article-title":"Model systems for investigation of cerebral vasospasm","author":"Boullin","year":"1980"},{"key":"b4","series-title":"J Neurol Neurosurg Psychiatry","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1136\/jnnp.39.8.756","article-title":"Evidence for the presence of a vasoactive substance (possibly involved in the aetiology of cerebral arterial spasm) in cerebrospinal fluid from patients with subarachnoid haemorrhage.","volume":"39","author":"Boullin","year":"1976"},{"key":"b5","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3171\/jns.1968.28.1.0001","article-title":"The biphasic response of cerebral vasospasm in experimental subarachnoid hemorrhage.","volume":"28","author":"Brawley","year":"1968"},{"key":"b6","series-title":"J Clin Pathol","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1136\/jcp.29.4.341","article-title":"Fibrin-fibrinogen degradation products in cerebrospinal fluid.","volume":"29","author":"Brueton","year":"1976"},{"key":"b7","article-title":"Fibrin(ogen) degradation products and cerebral vasospasm.","author":"Forster","year":"1981"},{"key":"b8","series-title":"Cerebral Arterial Spasm.","first-page":"186","article-title":"Interaction of fibrin degradation products and 5-hydroxytryptamine on various vascular smooth muscle preparations: possible role in cerebral vasospasm","author":"Forster","year":"1980"},{"key":"b9","series-title":"Br J Clin Pharmacol","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1111\/j.1365-2125.1980.tb01749.x","article-title":"Vascular smooth muscle response to fibrinogen degradation products and 5-hydroxytryptamine: possible role in cerebral vasospasm in man.","volume":"10","author":"Forster","year":"1980"},{"key":"b10","series-title":"Fibrinolysis: Current Fundamental and Clinical Concepts.","first-page":"97","article-title":"Features of the interaction of plasmin with fibrinogen","author":"Furlan","year":"1978"},{"key":"b11","series-title":"Fibrinolysis: Current Fundamental and Clinical Concepts.","first-page":"109","article-title":"Fibrin-plasmin interactions: a synthesis of molecular and clinical observations","author":"Gaffney","year":"1978"},{"key":"b12","series-title":"J Neurol Neurosurg Psychiatry","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1136\/jnnp.37.3.249","article-title":"Fibrin\/fibrinogen degradation products in cerebrospinal fluid of patients admitted to a psychiatric unit.","volume":"37","author":"Hunter","year":"1974"},{"key":"b13","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"468","DOI":"10.3171\/jns.1970.32.4.0468","article-title":"Experimental evaluation of potential spasmolytic drugs.","volume":"32","author":"Kapp","year":"1970"},{"key":"b14","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"293","DOI":"10.3171\/jns.1974.41.3.0293","article-title":"Role of prostaglandin F2 in human cerebral vasospasm.","volume":"41","author":"La Torre","year":"1974"},{"key":"b15","series-title":"J Biol Chem","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.1016\/S0021-9258(18)94373-5","article-title":"High molecular weight derivatives of human fibrinogen produced by plasmin. I. Physicochemical and immunological characterization.","volume":"244","author":"Marder","year":"1969"},{"key":"b16","series-title":"Trans Assoc Am Physicians","first-page":"156","article-title":"The importance of intermediate degradation products of fibrinogen in fibrinolytic hemorrhage.","volume":"80","author":"Marder","year":"1967"},{"key":"b17","series-title":"Cerebral Arterial Spasm.","first-page":"68","article-title":"Biochemistry of vascular smooth muscle: contractile mechanism of human basilar artery","author":"Miller","year":"1980"},{"key":"b18","series-title":"Neurol Med Chir","first-page":"103","article-title":"[Etiology and treatment of prolonged vasospasm: experimental and clinical studies.]","volume":"16","author":"Miyaoka","year":"1976"},{"key":"b19","series-title":"J Clin Invest","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1172\/JCI107183","article-title":"Immunobiology of fibrinogen. Emergence of neoantigenic expressions during physiologic cleavage in vitro and in vivo.","volume":"52","author":"Plow","year":"1973"},{"key":"b20","series-title":"Fibrinolysis: Current Fundamental and Clinical Concepts.","first-page":"61","article-title":"The interaction of human plasminogen with streptokinase","author":"Robbins","year":"1978"},{"key":"b21","series-title":"Hematology","first-page":"1294","article-title":"Mechanisms of fibrinolysis","author":"Sherry","year":"1977"},{"key":"b22","series-title":"J Neurol Neurosurg Psychiatry","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1136\/jnnp.38.7.650","article-title":"Responses of isolated human basilar arteries to 5-hydroxytryptamine, noradrenaline, serum, platelets, and erythrocytes.","volume":"38","author":"Starling","year":"1975"},{"key":"b23","series-title":"Ume\u00e5 (Sweden) Med Dissert","first-page":"1","article-title":"Studies on fibrinolysis in the central nervous system with special reference to intracranial haemorrhages and to the effect of antifibrinolytic drugs.","volume":"8","author":"Tovi","year":"1972"},{"key":"b24","series-title":"Acta Neurol Scand","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1111\/j.1600-0404.1972.tb07562.x","article-title":"Increased fibrinolytic activity and fibrin degradation products after experimental intracerebral haemorrhage.","volume":"48","author":"Tovi","year":"1972"},{"key":"b25","series-title":"Acta Neurol Scand","first-page":"1","article-title":"Fibrinolytic activity of the cerebrospinal fluid after subarachnoid haemorrhage.","volume":"49","author":"Tovi","year":"1973"},{"key":"b26","series-title":"Clin Neurosurg","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1093\/neurosurgery\/26.CN_suppl_1.643","article-title":"Vasospasm: an update.","volume":"26","author":"Zervas","year":"1979"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/56\/3\/article-p339.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/56\/3\/article-p339.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/56\/3\/article-p339.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,24]],"date-time":"2022-07-24T12:38:41Z","timestamp":1658666321000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/56\/3\/article-p339.xml"}},"subtitle":["Possible role in the etiology of cerebral arterial spasm"],"short-title":[],"issued":{"date-parts":[[1982,3]]},"references-count":26,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3171\/jns.1982.56.3.0339","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[1982,3]]}}}