{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:44:16Z","timestamp":1773423856887,"version":"3.50.1"},"reference-count":30,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1982,7]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 The efficacy of thromboxane synthetase inhibitor in the prevention of cerebral vasospasm after subarachnoid hemorrhage (SAH) was evaluated in a prolonged experiment using dogs. Changes in the diameter of the basilar artery were followed by angiography, and morphological changes were studied by photomicroscopy and electron microscopy. As a thromboxane synthetase inhibitor, OKY-1581 (sodium-(E)-3-(4(-3-pyridylmethyl)phenyl)-2-methylacrylate)was used. Dogs received intravenous injections of 160 mg of OKY-1581 dissolved in 2 ml of physiological saline immediately after subarachnoid blood injection. Subsequently, the animals received continuous intravenous infusion of the drug at the rate of 4 gm\/50 ml\/24 hours until sacrifice 4 days after induction of SAH. Control dogs received subarachnoid blood injection without treatment with OKY-1581.<\/jats:p>\n<jats:p content-type=\"fine-print\">Angiographic examination revealed that the late spasm was almost completely abolished by the treatment with OKY-1581. Early spasm was also prevented, but the drug's effect was less prominent than it was on the late spasm. Morphological study revealed degenerative changes in the endothelium and myonecrotic changes in the tunica media following SAH in the basilar arteries of the treated as well as the untreated dogs. However, corrugation of the internal elastic lamina was almost completely absent in the treated dogs.<\/jats:p>\n<jats:p content-type=\"fine-print\">The above results indicate that a disproportionate synthesis of thromboxane A<jats:sub>2<\/jats:sub> plays an important role in the evolution of chronic cerebral vasospasm following SAH, and that drugs such as OKY-1581 that selectively inhibit thromboxane synthetase might be useful in the prevention of vasospasm.<\/jats:p>","DOI":"10.3171\/jns.1982.57.1.0074","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T13:57:50Z","timestamp":1241791070000},"page":"74-82","source":"Crossref","is-referenced-by-count":59,"title":["Prevention of cerebral vasospasm after SAH with a thromboxane synthetase inhibitor, OKY-1581"],"prefix":"10.3171","volume":"57","author":[{"given":"Tomio","family":"Sasaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Wakai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Asano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kintomo","family":"Takakura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Sano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Neurol Res","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1080\/01616412.1980.11739583","article-title":"Pathogenesis of cerebral vasospasm.","volume":"2","author":"Alksne","year":"1980"},{"key":"b2","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1161\/01.STR.10.6.638","article-title":"Prevention of experimental subarachnoid hemorrhage-induced intracranial arterial vasonecrosis with phosphodiesterase inhibitor phthalazinol (EG-626).","volume":"10","author":"Alksne","year":"1979"},{"key":"b3","series-title":"Neurol Med Chir","article-title":"In vitro evaluation of the inhibitory action of PGI2 on vasoconstrictions induced by various prostaglandins, serotonin and hemoglobin using the canine basilar artery.","author":"Asano"},{"key":"b4","series-title":"No To Shinkei","first-page":"33","article-title":"[Lipid peroxidation and cerebral vasospasm.]","volume":"33","author":"Asano","year":"1981"},{"key":"b5","series-title":"Cerebral Arterial Spasm","first-page":"190","article-title":"Possible participation of free radical reactions initiated by clot lysis in the pathogenesis of vasospasm after subarachnoid hemorrhage","author":"Asano","year":"1981"},{"key":"b6","series-title":"Adv Gerontol Res","first-page":"355","article-title":"Lipid peroxidation: its measurement, occurrence and significance in animal tissues.","volume":"2","author":"Barber","year":"1967"},{"key":"b7","series-title":"Br J Clin Pharmacol","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/j.1365-2125.1979.tb00914.x","article-title":"Responses of human and baboon arteries to prostaglandin endoperoxides and biologically generated and synthetic prostacyclin: their relevance to cerebral arterial spasm in man.","volume":"7","author":"Boullin","year":"1979"},{"key":"b8","series-title":"Prostaglandins","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/0090-6980(79)90008-X","article-title":"Effects of prostacyclin on the canine isolated basilar artery.","volume":"17","author":"Chapleau","year":"1979"},{"key":"b9","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1161\/01.STR.8.4.480","article-title":"Cerebral arterial smooth muscle contraction by thromboxane A2.","volume":"8","author":"Ellis","year":"1977"},{"key":"b10","series-title":"Eur J Pharmacol","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/0014-2999(81)90464-7","article-title":"OKY-1581, a potential selective thromboxane synthetase inhibitor.","volume":"69","author":"Feuerstein","year":"1981"},{"key":"b11","series-title":"Biochemistry and Mode of Action of Hormones II. 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