{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:07:08Z","timestamp":1761743228733},"reference-count":30,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1982,7]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 The authors present a case of proximal myopathy secondary to epsilon-aminocaproic acid (EACA) administration. This well recognized entity does not occur immediately after institution of therapy, but follows a delay of several days and a cumulative dose. Its consequences include a spectrum of symptoms from myalgias to severe myopathy with rhabdomyolysis, myoglobinuria, and acute tubular necrosis. A presenting symptom of calf pain in a patient receiving EACA should not automatically imply deep vein thrombosis. Serial creatine phosphokinase measurements are essential in monitoring a patient undergoing EACA therapy, especially after 2 weeks of treatment and a total dose of greater than 500 gm.<\/jats:p>","DOI":"10.3171\/jns.1982.57.1.0130","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T13:57:50Z","timestamp":1241791070000},"page":"130-134","source":"Crossref","is-referenced-by-count":24,"title":["Myopathy induced by epsilon-aminocaproic acid"],"prefix":"10.3171","volume":"57","author":[{"given":"Jeffrey A.","family":"Brown","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert L.","family":"Wollmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean","family":"Mullan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Acta Chir Scand","first-page":"552","article-title":"Antifibrinolytic treatment with epsilonaminocaproic acid in connection with prostatectomy.","volume":"127","author":"Andersson","year":"1964"},{"key":"b2","series-title":"Acta Chir Scand","first-page":"251","article-title":"Fibrinolytic states in prostatic disease and their treatment with epsilon-amino-caproic acid.","volume":"126","author":"Andersson","year":"1963"},{"key":"b3","series-title":"Postgrad Med J","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1136\/pgmj.47.554.813","article-title":"Hypokalaemic myopathy and myoglobinuria due to carbenoxolone sodium.","volume":"47","author":"Barnes","year":"1971"},{"key":"b4","series-title":"Postgrad Med J","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1136\/pgmj.48.561.440","article-title":"Myopathy from E-aminocaproic acid: a second case.","volume":"48","author":"Bennet","year":"1972"},{"issue":"6","key":"b5","series-title":"Med Clin North Am","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1016\/S0025-7125(16)33112-1","article-title":"The complications of therapy with epsilonaminocaproic acid.","volume":"50","author":"Bergin","year":"1966"},{"key":"b6","series-title":"Br Med J","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1136\/bmj.281.6233.115-a","article-title":"Acute renal failure and myopathy after treatment with aminocaproic acid.","volume":"281","author":"Biswas","year":"1980"},{"key":"b7","series-title":"Arch Neurol","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1001\/archneur.1980.00500520085021","article-title":"Rhabdomyolysis during treatment with epsilon-aminocaproic acid.","volume":"37","author":"Britt","year":"1980"},{"key":"b8","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"690","DOI":"10.3171\/jns.1980.53.5.0690","article-title":"Myoglobinuria following epsilon-aminocaproic acid (EACA) therapy. 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