{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T12:23:44Z","timestamp":1772195024537,"version":"3.50.1"},"reference-count":32,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1982,9]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 The authors have studied the ability of prostacyclin to reverse contractions of human basilar arteries <jats:italic>in vitro<\/jats:italic> that were induced by a wide range of substances implicated in the etiology of cerebral arterial spasm. Prostacyclin (10\u221210 to 10\u22126M) caused a dose-related reversal of contractions induced by 5-hydroxytryptamine, noradrenaline, angiotensin II, prostaglandin (PG)F<jats:sub>2\u03b1<\/jats:sub>, and U-46619 (a thromboxane-A<jats:sub>2<\/jats:sub> mimetic). These agents were tested at concentrations or volumes that produced almost maximum or maximum responses and those that produced approximately 50% of the maximum response. Contractions induced by maximum concentrations of angiotensin II and U-46619 were least affected by prostacyclin. In addition, contractions induced by thromboxane-A<jats:sub>2<\/jats:sub> generated from guinea-pig lung were reversed in a dose-dependent fashion by prostacyclin. This ability of prostacyclin to physiologically antagonize contractions of the human basilar artery <jats:italic>in vitro<\/jats:italic> induced by high concentrations of various spasmogenic agents suggests that such a potent vasodilator agent or more stable analogue may be of value in the treatment of such disorders as cerebral arterial spasm following subarachnoid hemorrhage.<\/jats:p>","DOI":"10.3171\/jns.1982.57.3.0334","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T13:57:07Z","timestamp":1241791027000},"page":"334-340","source":"Crossref","is-referenced-by-count":39,"title":["Prostacyclin and cerebral vessel relaxation"],"prefix":"10.3171","volume":"57","author":[{"given":"Kamal S.","family":"Paul","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric T.","family":"Whalley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Forster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Lye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Dutton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"440","DOI":"10.3171\/jns.1974.41.4.0440","article-title":"Experimental catecholamine-induced chronic cerebral vasospasm. 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