{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T01:46:16Z","timestamp":1783647976139,"version":"3.55.0"},"reference-count":27,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1983,8]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Giant-cell tumor rarely affects the sphenoid bone. Ten cases of this tumor seen at the Mayo Clinic are reviewed, bringing the number of cases in the world literature to 31. These tumors, which present in the second and third decades of life and are slightly more frequent in women than in men, may present with various symptoms, including headache, visual field defects, blindness, and diplopia. The symptom complex and roentgenographic findings are seldom, if ever, sufficiently characteristic to allow preoperative diagnosis. The microscopic differential diagnosis of giant-cell tumor of the sphenoid region includes giant-cell reparative granuloma, aneurysmal bone cyst, fibrous dysplasia, and \u201cbrown tumor\u201d of hyperparathyroidism. Interesting features of this series include the presence of multifocal giant-cell tumor in one case, and the absence of Paget's disease of bone in every case. Complete follow-up review in these cases allowed a discussion of therapy and prognosis; it appears that subtotal excision with postoperative radiation therapy is the treatment of choice. While the histological appearance of giant-cell tumor is characteristic, caution must be exercised in interpreting small samples, and various reparative and metabolic disorders must be considered in the differential diagnosis.<\/jats:p>","DOI":"10.3171\/jns.1983.59.2.0322","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T16:17:02Z","timestamp":1241799422000},"page":"322-327","source":"Crossref","is-referenced-by-count":80,"title":["Giant-cell tumor of the sphenoid bone"],"prefix":"10.3171","volume":"59","author":[{"given":"James T.","family":"Wolfe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd W.","family":"Scheithauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Dahlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Ital J Orthop Traumatol","first-page":"249","article-title":"Giant-cell tumours of bone: a study of 209 cases with long-term follow-up in 130.","volume":"1","author":"Campanacci","year":"1975"},{"key":"b2","series-title":"Bone Tumors: General Aspects and Data on 6,221 Cases","author":"Dahlin","year":"1978"},{"key":"b3","series-title":"Cancer","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1002\/1097-0142(197005)25:5<1061::AID-CNCR2820250509>3.0.CO;2-E","article-title":"Giant-cell tumor: a study of 195 cases.","volume":"25","author":"Dahlin","year":"1970"},{"key":"b4","series-title":"Can J Neurol Sci","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1017\/S0317167100025257","article-title":"Giant cell tumor of the sphenoid bone.","volume":"4","author":"Doshi","year":"1977"},{"key":"b5","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3171\/jns.1945.2.1.0016","article-title":"Giant cell tumor of the sphenoid bone. 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Diagnostic criteria and review of the literature with the first case described in the temporal bone.","volume":"5","author":"Hirschl","year":"1974"},{"key":"b15","series-title":"Arch Pathol","first-page":"993","article-title":"Giant cell tumor of bone. Its pathologic appearance, grading, supposed variants and treatment.","volume":"30","author":"Jaffe","year":"1940"},{"key":"b16","series-title":"Neurol India","first-page":"57","article-title":"Giant cell tumour of the skull. (A case report.)","volume":"14","author":"Kanaka","year":"1966"},{"key":"b17","series-title":"Surg Neurol","first-page":"105","article-title":"Giant cell tumor of sphenoid bone: malignant transformation following radiotherapy.","volume":"2","author":"Martins","year":"1974"},{"key":"b18","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"169","DOI":"10.3171\/jns.1949.6.2.0169","article-title":"Giant-cell tumor of bones of the skull. 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