{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T05:11:38Z","timestamp":1761109898403},"reference-count":20,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1983,10]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 The authors describe six patients with pituitary macroadenomas hypersecreting only the alpha subunit of the glycoprotein hormones. These patients had been previously diagnosed as having \u201cnon-functioning chromophobe adenomas.\u201d All of the patients had visual field abnormalities and partial hypopituitarism. The elevated serum alpha concentrations showed a variable response to stimulation by thyrotropin-releasing hormone, and could not be suppressed by thyroid hormone administration. Immunological, gel chromatographic, and immunocytochemical studies documented that only the alpha subunit was present. Following pituitary surgery and radiotherapy, serum alpha levels decreased. These patients represent a new subset of functioning pituitary tumors. Determination of alpha subunit concentration is useful in managing some patients with pituitary tumors previously thought to have non-functioning chromophobe adenomas.<\/jats:p>","DOI":"10.3171\/jns.1983.59.4.0585","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T16:17:29Z","timestamp":1241799449000},"page":"585-589","source":"Crossref","is-referenced-by-count":40,"title":["Pure alpha subunit-secreting pituitary tumors"],"prefix":"10.3171","volume":"59","author":[{"given":"Anne","family":"Klibanski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. Chester","family":"Ridgway","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas T.","family":"Zervas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Clin Endocrinol Metab","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1210\/jcem-38-4-674","article-title":"Radioimmunological characterization of human thyrotropin and its subunits: applications for the measurement of human TSH.","volume":"38","author":"Binoux","year":"1974"},{"key":"b2","series-title":"J Clin Endocrinol Metab","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1210\/jcem-42-1-132","article-title":"Hyperprolactinemic anovulatory syndrome.","volume":"42","author":"Bohnet","year":"1976"},{"key":"b3","series-title":"N Engl J Med","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1056\/NEJM197810192991602","article-title":"Prolactin-secreting tumors and hypogonadism in 22 men.","volume":"299","author":"Carter","year":"1978"},{"key":"b4","series-title":"Br Med J","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1136\/bmj.1.5958.604","article-title":"Prolactin studies in \u201cfunctionless\u201d pituitary tumours.","volume":"1","author":"Child","year":"1975"},{"issue":"1","key":"b5","series-title":"Clin Endocrinol Metab","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/S0300-595X(78)80043-7","article-title":"Unusual types of hyperthyroidism.","volume":"7","author":"Cooper","year":"1978"},{"key":"b6","series-title":"J Clin Endocrinol Metab","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1210\/jcem-43-3-650","article-title":"FSH-secreting pituitary adenomas: stimulation and suppression studies in two patients.","volume":"43","author":"Friend","year":"1976"},{"key":"b7","series-title":"J Clin Endocrinol Metab","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1210\/jcem-45-3-534","article-title":"Thyrotropin-induced hyperthyroidism: use of alpha and beta subunit levels to identify patients with pituitary tumors.","volume":"45","author":"Kourides","year":"1977"},{"key":"b8","series-title":"Endocrinology","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1210\/endo-94-5-1411","article-title":"Alpha and beta subunits of human thyrotropin: purification and development of specific radioimmunoassays.","volume":"94","author":"Kourides","year":"1974"},{"key":"b9","series-title":"Clin Endocrinol","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1111\/j.1365-2265.1978.tb01511.x","article-title":"Thyroid hormone, oestrogen, and glucocorticoid effects on two different pituitary glycoprotein hormone alpha subunit pools.","volume":"9","author":"Kourides","year":"1978"},{"key":"b10","series-title":"J Clin Endocrinol Metab","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1210\/jcem-37-5-836","article-title":"Increase in the beta subunit of human TSH in hypothyroid serum after thyrotropin releasing hormone.","volume":"37","author":"Kourides","year":"1973"},{"key":"b11","series-title":"J Clin Endocrinol Metab","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1210\/jcem-40-5-872","article-title":"Pituitary secretion of free alpha and beta subunit of human thyrotropin in patients with thyroid disorders.","volume":"40","author":"Kourides","year":"1975"},{"key":"b12","series-title":"J Clin Endocrinol Metab","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1210\/jcem-43-1-97","article-title":"Secretion of alpha subunit of glycoprotein hormones by pituitary adenomas.","volume":"43","author":"Kourides","year":"1976"},{"key":"b13","series-title":"J Clin Pathol","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1136\/jcp.29.3.250","article-title":"Localization of prolactin in chromophobe pituitary adenomas: study of human necropsy material by immunoperoxidase technique.","volume":"29","author":"Kovacs","year":"1976"},{"key":"b14","series-title":"Clin Endocrinol","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1111\/j.1365-2265.1980.tb01045.x","article-title":"Glycoprotein hormone \u03b1 subunit secretion by pituitary adenomas: influence of external irradiation.","volume":"13","author":"Macfarlane","year":"1980"},{"key":"b15","series-title":"J Clin Endocrinol Metab","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1210\/jcem-52-4-692","article-title":"Luteinizing hormone- and \u03b1-subunit-secreting pituitary tumor: positive feedback of estrogen.","volume":"52","author":"Peterson","year":"1981"},{"key":"b16","series-title":"Endocrinology","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1210\/endo-89-6-1331","article-title":"Eli Lilly Lecture: The subunits of pituitary thyrotropin \u2014 their relationship to other glycoprotein hormones.","volume":"89","author":"Pierce","year":"1971"},{"key":"b17","series-title":"N Engl J Med","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1056\/NEJM198105213042102","article-title":"Pure alpha-secreting pituitary adenomas.","volume":"304","author":"Ridgway","year":"1981"},{"key":"b18","series-title":"J Clin Invest","doi-asserted-by":"publisher","first-page":"2783","DOI":"10.1172\/JCI107474","article-title":"Suppression of pituitary TSH secretion in the patient with a hyperfunctioningthyroidnodule.","volume":"52","author":"Ridgway","year":"1973"},{"key":"b19","series-title":"J Clin Endocrinol Metab","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1210\/jcem-42-3-544","article-title":"Hypersecretion of LH and FSH by a pituitary adenoma.","volume":"42","author":"Snyder","year":"1976"},{"key":"b20","series-title":"Arch Pathol Lab Med","first-page":"113","article-title":"Immunoperoxidase techniques. Practical and theoretical aspects.","volume":"102","author":"Taylor","year":"1978"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/59\/4\/article-p585.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/59\/4\/article-p585.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/59\/4\/article-p585.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,13]],"date-time":"2022-11-13T03:56:03Z","timestamp":1668311763000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/59\/4\/article-p585.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,10]]},"references-count":20,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.3171\/jns.1983.59.4.0585","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[1983,10]]}}}