{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:41:29Z","timestamp":1760298089595},"reference-count":15,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1983,11]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 In order to examine the effects of verapamil on intracranial pressure (ICP) in patients with compromised intracranial compliance, five hypertensive patients with supratentorial tumors were given verapamil, 5 mg intravenously, at the time of anesthesia induction. Within 4 minutes, ICP increased 67% from 18 \u00b1 4 mm Hg (standard error) to 27 \u00b1 5 mm Hg (p &lt; 0.05), whereas mean arterial pressure decreased 20% from 111 \u00b1 7 mm Hg to 89 \u00b1 4 mm Hg (p &lt; 0.05), and cerebral perfusion pressure (CPP) decreased 33% from 93 \u00b1 11 mm Hg to 62 \u00b1 6 mm Hg (p &lt; 0.05). The increases in ICP responded promptly to hyperventilation and intravenous lidocaine (1.5 mg\/kg). A control group of five hypertensive patients with supratentorial tumors received the same anesthetic agents without verapamil. In this group, ICP and CPP were unchanged. The authors conclude that calcium entry-blockers, such as verapamil, should be avoided in patients with compromised intracranial compliance unless ICP is being monitored and proper therapy for intracranial hypertension can be rapidly instituted.<\/jats:p>","DOI":"10.3171\/jns.1983.59.5.0800","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T16:18:54Z","timestamp":1241799534000},"page":"800-802","source":"Crossref","is-referenced-by-count":24,"title":["Adverse impact of a calcium entry-blocker (verapamil) on intracranial pressure in patients with brain tumors"],"prefix":"10.3171","volume":"59","author":[{"given":"Robert F.","family":"Bedford","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph","family":"Dacey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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