{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T07:04:04Z","timestamp":1742799844119},"reference-count":26,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1983,12]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 The authors report a 12-year follow-up review of 33 patients treated with chymopapain (Discase) injection for intervertebral disc disease. This carefully controlled series of patients was treated under local anesthesia in the prone position. Only the single offending disc that correlated with the myelographic and clinical pathology (without the use of discography) was injected with Discase. Anaphylaxis is treated instantly at the first sign of disturbance, and no patients suffered shock. The percentage of patients who were completely cured or improved continues at about 70%. Aside from sensitivity, complications attributable to proper use of the enzyme remain at zero. Follow-up review of those patients over 10 years would indicate that there is no risk of delayed organ toxicity, no risk of carcinogenesis, and no apparent risk of first-generation teratogenesis.<\/jats:p>","DOI":"10.3171\/jns.1983.59.6.0990","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T16:20:59Z","timestamp":1241799659000},"page":"990-993","source":"Crossref","is-referenced-by-count":20,"title":["Late results of treatment of intervertebral disc disease with chymopapain"],"prefix":"10.3171","volume":"59","author":[{"given":"Dwight","family":"Parkinson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Surg Clin North Am","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/S0039-6109(16)40541-4","article-title":"Chemonucleolysis in the treatment of low back pain and sciatica.","volume":"55","author":"Apfelbach","year":"1975"},{"key":"b2","series-title":"Clin Biochem","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/S0009-9120(83)90291-6","article-title":"Increased glycosaminoglycan excretion after chymopapain injection of intervertebral discs.","volume":"16","author":"Bowness","year":"1983"},{"key":"b3","series-title":"Clin Orthop","first-page":"94","article-title":"Clinical studies on chemonucleolysis.","volume":"67","author":"Brown","year":"1969"},{"key":"b4","series-title":"Orthop Rev","first-page":"25","article-title":"Chymopapain (Discase) for chemonucleolysis for lumbar discs in United States.","volume":"7","author":"Ford","year":"1978"},{"key":"b5","series-title":"Spine","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1097\/00007632-198211000-00016","article-title":"Chymopapain for the treatment of intervertebral disc herniation. 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