{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:35:52Z","timestamp":1790300152087,"version":"4.1.0"},"reference-count":58,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1983,12]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Earlier reports have suggested that low-dose ionizing irradiation might be involved in induction of intracranial meningiomas. One of the problems in evaluating irradiation-induced neoplasms is the belief that these tumors have no distinguishing features to indicate their etiology. In an attempt to identify such features in meningiomas following irradiation, a group of 42 post-irradiation meningiomas (PIM's) has been compared with a group of 84 non-PIM control meningiomas. These 42 PIM's included all the intracranial meningiomas diagnosed at the Hadassah University Hospital during the years 1952 to 1981 in individuals treated in childhood with low-dose x-ray therapy for tinea capitis. Although the individual PIM does not seem to differ from a \u201cspontaneous\u201d meningioma, this study indicates that PIM's as a group have distinct characteristics, namely, their location at the site of maximal irradiation, and features suggesting rapid growth and aggressive biological behavior. There was a significantly higher number of calvarial tumors (p &lt; 0.001), a high proportion of multiple meningiomas, a higher recurrence rate following apparent complete excision (p &lt; 0.02), and an increased number of histologically malignant meningiomas (p &lt; 0.01). The demonstration of features that distinguish PIM's from meningiomas of other etiology supports the suggestion that low-dose ionizing irradiation was involved in the pathogenesis of these tumors.<\/jats:p>","DOI":"10.3171\/jns.1983.59.6.1048","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T16:20:59Z","timestamp":1241799659000},"page":"1048-1053","source":"Crossref","is-referenced-by-count":126,"title":["Intracranial meningiomas following low-dose irradiation to the head"],"prefix":"10.3171","volume":"59","author":[{"given":"Dov","family":"Soffer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Pittaluga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Feiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron J.","family":"Beller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Acta Neurochir","first-page":"279","article-title":"Multiple meningiomas.","volume":"31","author":"Abtahi","year":"1975"},{"key":"b2","series-title":"Neurochirurgia (Stuttg)","first-page":"67","article-title":"Multiple meningiomas.","volume":"24","author":"Andrioli","year":"1981"},{"key":"b3","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1227\/00006123-197903000-00001","article-title":"Head trauma and subsequent brain tumors.","volume":"4","author":"Annegers","year":"1979"},{"key":"b4","series-title":"Neurochirurgia (Stuttg)","first-page":"135","article-title":"The possible relationship between small dose irradiation to the scalp and intracranial meningiomas.","volume":"15","author":"Beller","year":"1972"},{"key":"b5","series-title":"Acta Neurochir","first-page":"285","article-title":"Survey on 101 meningiomas (1965\u20131973).","volume":"31","author":"Bockhorn","year":"1975"},{"key":"b6","series-title":"Surg Neurol","first-page":"379","article-title":"The possible role of radiation in oncogenesis of meningioma.","volume":"2","author":"Bogdanowicz","year":"1974"},{"key":"b7","author":"Bryk"},{"key":"b8","series-title":"Cancer","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1002\/1097-0142(196811)22:6<1323::AID-CNCR2820220632>3.0.CO;2-H","article-title":"Some epidemiologic aspects of neoplastic diseases in Israeli immigrant population. 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