{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T12:44:45Z","timestamp":1767703485577},"reference-count":19,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1984,3]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 This study has been carried out to evaluate the effect of supratentorial mass lesions on the local cerebral blood flow (CBF) of the brain stem. Local CBF of the thalamus, inferior colliculus, and medulla oblongata, and supra- and infratentorial pressure were serially measured in 52 cats with intracranial hypertension produced by supratentorial balloon expansion. The mean control local CBF's in the thalamus, inferior colliculus, and medulla oblongata were 37.5, 42.1, and 30.7 ml\/100 gm\/min, respectively. At 20 to 30 mm Hg of supratentorial pressure, the local CBF of the thalamus started to decrease, and at 20 mm Hg of infratentorial pressure, the local CBF of the inferior colliculus began to decrease. Finally, at 40 to 60 mm Hg of infratentorial pressure, the local CBF of the medulla oblongata was affected. At the beginning of uncal herniation, indicated by anisocoria, the mean local CBF of the inferior colliculus abruptly decreased from 33.7 to 19.6 ml\/100 gm\/min in 16 cats. The Cushing response was evoked at a mean supratentorial pressure of 93.4 mm Hg and infratentorial pressure of 49.9 mm Hg in 16 cats. When the systemic arterial pressure was increased to the highest level in 13 cats, the mean local CBF of the medulla oblongata did not show significant change (a decrease from 22.8 to 20.9 ml\/100 gm\/min). The results suggest that at the beginning of uncal herniation, the local CBF of the upper brain stem markedly decreased. During the Cushing response, the local CBF of the medulla oblongata did not change significantly.<\/jats:p>","DOI":"10.3171\/jns.1984.60.3.0566","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T16:22:49Z","timestamp":1241799769000},"page":"566-571","source":"Crossref","is-referenced-by-count":39,"title":["Acute intracranial hypertension and brain-stem blood flow"],"prefix":"10.3171","volume":"60","author":[{"given":"Seigo","family":"Nagao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norio","family":"Sunami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takumi","family":"Tsutsui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Honma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiyuki","family":"Momma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsukasa","family":"Nishiura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Nishimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Neurol Neurosurg Psychiatry","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1136\/jnnp.37.6.627","article-title":"Effects of increased supratentorial pressure in cats.","volume":"37","author":"Beks","year":"1974"},{"key":"b2","series-title":"Bull Johns Hopkins Hosp","first-page":"290","article-title":"Concerning a definite regulatory mechanism of the vaso-motor centre which controls blood pressure during cerebral compression.","volume":"12","author":"Cushing","year":"1901"},{"key":"b3","series-title":"Transtentorial Herniation.","first-page":"53","author":"Finney","year":"1962"},{"key":"b4","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"601","DOI":"10.3171\/jns.1973.39.5.0601","article-title":"Vascular pathology of the brain stem due to experimentally increased intracranial pressure: changes noted in the micro- and macrocirculation.","volume":"39","author":"Goodman","year":"1973"},{"key":"b5","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"514","DOI":"10.3171\/jns.1972.37.5.0514","article-title":"The effects of mass-induced intracranial pressures on arterial hypertension and survival in awake cats.","volume":"37","author":"Goodman","year":"1972"},{"key":"b6","series-title":"Arch Neurol","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1001\/archneur.1961.00450120013003","article-title":"Experimental brain compression. 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Part 1: Changes in the auditory brain-stem and somatosensory evoked responses in intracranial hypertension in cats.","volume":"51","author":"Nagao","year":"1979"},{"key":"b11","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"846","DOI":"10.3171\/jns.1979.51.6.0846","article-title":"Acute intracranial hypertension and auditory brain-stem responses. Part 2: The effects of brain-stem movement on the auditory brain-stem responses due to transtentorial herniation.","volume":"51","author":"Nagao","year":"1979"},{"key":"b12","series-title":"The Diagnosis of Stupor and Coma","first-page":"73","author":"Plum","year":"1972"},{"key":"b13","series-title":"Acta Neurol Scand","first-page":"520","article-title":"Brain stem blood flow during raised intracranial pressure.","volume":"56","author":"Rowan","year":"1977"},{"key":"b14","series-title":"Arch Neurol Psychiatry","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1001\/archneurpsyc.1945.02300040035006","article-title":"Transtentorial herniation of the brain stem. A characteristic clinicopathologic syndrome; pathogenesis of hemorrhages in the brain stem.","volume":"53","author":"Scheinker","year":"1945"},{"key":"b15","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"594","DOI":"10.3171\/jns.1974.40.5.0594","article-title":"Interrelationship between blood pressure and regional cerebral blood flow in experimental intracranial hypertension.","volume":"40","author":"Shalit","year":"1974"},{"key":"b16","series-title":"A Stereotaxic Atlas of the Cat Brain.","author":"Snider","year":"1961"},{"key":"b17","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"664","DOI":"10.3171\/jns.1959.16.6.0664","article-title":"Dynamic axial brain-stem distortion as a mechanism explaining the cardiorespiratory changes in increased intracranial pressure.","volume":"16","author":"Thompson","year":"1959"},{"key":"b18","series-title":"Brain","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1093\/brain\/76.3.364","article-title":"Ischaemic lesions in the brain-stem associated with raised supratentorial pressure.","volume":"76","author":"Wolman","year":"1953"},{"key":"b19","series-title":"Intracranial Pressure V.","article-title":"Cerebral blood flow in the brain stem during increased ICP","author":"Zierski"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/60\/3\/article-p566.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/60\/3\/article-p566.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/60\/3\/article-p566.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,24]],"date-time":"2022-07-24T19:43:18Z","timestamp":1658691798000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/60\/3\/article-p566.xml"}},"subtitle":["An experimental study"],"short-title":[],"issued":{"date-parts":[[1984,3]]},"references-count":19,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3171\/jns.1984.60.3.0566","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[1984,3]]}}}