{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T23:27:20Z","timestamp":1698535640194},"reference-count":24,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1984,3]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 High-dose sodium thiopental is frequently used in neuroanesthesia. The authors performed a study to compare a shorter-acting barbiturate, methohexital, to sodium thiopental in producing high-dose barbiturate anesthesia. In two groups of five mongrel dogs each, regional cerebral blood flow (CBF) was determined using the radioactive-microsphere technique, and cardiovascular parameters were measured before, during, and 1 hour after a 1\u00bdhour period of deep barbiturate anesthesia with either sodium thiopental or methohexital. Doses of the barbiturates were adjusted to produce electroencephalogram burst suppression of greater than 30 seconds.<\/jats:p>\n<jats:p content-type=\"fine-print\">Both agents produced a similar degree of cardiac depression, reduction in CBF, and decrease in cerebral metabolic rate of oxygen (CMRO<jats:sub>2<\/jats:sub>). Changes in cerebral and peripheral vascular resistance indicated that methohexital caused less vasoconstriction than sodium thiopental. When the barbiturate infusions were discontinued, CMRO<jats:sub>2<\/jats:sub> and CBF returned more rapidly toward control values in the methohexital group than in the thiopental group. The more rapid recovery time and decrease in cerebral vascular resistance with methohexital suggest that it may have some advantage over sodium thiopental during certain neurosurgical procedures.<\/jats:p>","DOI":"10.3171\/jns.1984.60.3.0602","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T16:22:49Z","timestamp":1241799769000},"page":"602-608","source":"Crossref","is-referenced-by-count":12,"title":["Comparison of sodium thiopental and methohexital for high-dose barbiturate anesthesia"],"prefix":"10.3171","volume":"60","author":[{"given":"David J.","family":"Boarini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neal F.","family":"Kassell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans C.","family":"Coester","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Anesthesiology","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1097\/00000542-198003000-00002","article-title":"Brain intracellular pH, blood flow, and blood-brain barrier differences with barbiturate and halothane anesthesia in the cat.","volume":"52","author":"Anderson","year":"1980"},{"key":"b2","series-title":"Anesthesiology","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1097\/00000542-197809000-00008","article-title":"Plasma levels of thiopental necessary for anesthesia.","volume":"49","author":"Becker","year":"1978"},{"key":"b3","series-title":"Anesthesiology","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1097\/00000542-197809000-00009","article-title":"Cardiovascular effects of plasma levels of thiopental necessary for anesthesia.","volume":"49","author":"Becker","year":"1978"},{"key":"b4","series-title":"J Pharmacol Exp Ther","first-page":"108","article-title":"The relative potencies of methohexital and thiopental.","volume":"129","author":"Bellville","year":"1960"},{"key":"b5","series-title":"Anesthesiology","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1097\/00000542-196305000-00013","article-title":"Physiologic disposition of methohexital in man.","volume":"24","author":"Brand","year":"1963"},{"key":"b6","series-title":"Surg Gynecol Obstet","first-page":"427","article-title":"Comparison of the recovery from methohexital and thiopental anesthesia in man.","volume":"109","author":"Egbert","year":"1959"},{"key":"b7","series-title":"Lancet","first-page":"68","article-title":"Recovery after intravenous barbiturate anaesthesia. 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