{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T17:46:14Z","timestamp":1759599974268},"reference-count":12,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1984,4]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 The natural history of intracranial arterial stenosis is not well understood. The lesions are pathologically quite diverse, and are subject to resolution, progression, or occlusion. The authors undertook an investigation to examine what effects, if any, extracranial-intracranial (EC-IC) bypass surgery had on the evolution of intracranial arterial stenosis in 18 patients undergoing EC-IC bypass procedures for ipsilateral hemispheric ischemia. There was inaccessible internal carotid artery stenosis in 14 patients, and middle cerebral artery stenosis in four patients. Early (within 2 weeks) and late (at 6 months) postoperative angiography was performed in all patients. During the period of the study, there was a significant change in the arterial stenosis in 50% of the patients (nine of 18). The stenotic artery became occluded in four patients while the grafts were widely patent. The occlusion occurred within a few days after the operation in three of the four cases, and was accompanied by an ischemic stroke in these patients. There was improvement or resolution of the stenotic lesion in five patients; the graft became occluded in two of these cases and was patent but showed poor cortical artery filling in the other three. All these patients remained asymptomatic and the change was detected on routine late postoperative angiograms. It is concluded that arterial stenoses should not be viewed as static or inflexible lesions, and that EC-IC bypass procedures can modify the hemodynamic parameters across stenotic lesions, predisposing them to improvement or worsening. This, in turn, may affect bypass patency. Such hemodynamic interactions are accompanied by ischemic symptoms in some patients, and contribute to the relatively higher morbidity associated with EC-IC bypass surgery in the setting of arterial stenosis.<\/jats:p>","DOI":"10.3171\/jns.1984.60.4.0771","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T16:19:25Z","timestamp":1241799565000},"page":"771-776","source":"Crossref","is-referenced-by-count":40,"title":["Changes in intracranial stenotic lesions after extracranial-intracranial bypass surgery"],"prefix":"10.3171","volume":"60","author":[{"given":"Issam","family":"Awad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony J.","family":"Furlan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Little","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Cereb Blood Flow Metab","first-page":"596","article-title":"Regional cerebral blood flow in extracranial-intracranial bypass surgery.","volume":"3","author":"Awad","year":"1983"},{"key":"b2","series-title":"AJR","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2214\/ajr.104.1.1","article-title":"Natural history and surgical treatment of occlusive cerebrovascular disease evaluated by serial arteriography.","volume":"104","author":"Bauer","year":"1968"},{"key":"b3","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1161\/01.STR.13.6.825","article-title":"Intracranial internal carotid artery 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