{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:04:35Z","timestamp":1758816275559},"reference-count":24,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1984,5]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 A case is reported of malignant schwannomatosis (malignant transformation of von Recklinghausen's disease) with catecholamine production in a patient with multiple intracranial aneurysms. The patient had a history of episodic hypertension and elevated levels of catecholamines in the serum and 24-hour urinary excretion. Postmortem examination revealed diffuse central nervous sytem (CNS) dissemination of the tumor from the thoracolumbar spinal malignant schwannoma. A high concentration of catecholamines was demonstrated in the tumor tissue, and histochemical and electron microscopy studies suggested the presence of catecholamines in the cytoplasm of some of the tumor cells. This patient's clinical and radiological features, including severe headache, vomiting, stiff neck, ptosis of the eye ipsilateral to the internal carotid-posterior communicating artery aneurysms, and local arterial narrowing, mimicked those of subarachnoid hemorrhage from a ruptured aneurysm. However, the clinical picture was caused by diffuse CNS dissemination of the tumor, another primary malignant schwannoma of the oculomotor nerve, and intimal fibrous thickening of the arterial wall.<\/jats:p>","DOI":"10.3171\/jns.1984.60.5.1089","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T18:33:32Z","timestamp":1241807612000},"page":"1089-1094","source":"Crossref","is-referenced-by-count":18,"title":["Catecholamine-secreting malignant schwannoma in a patient with multiple intracranial aneurysms"],"prefix":"10.3171","volume":"60","author":[{"given":"Hiroshi","family":"Hasegawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoji","family":"Bitoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Otsuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomio","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Acta Neurol Psychiat Belg","first-page":"529","article-title":"A propos des an\u00e9vrysmes des art\u00e8res c\u00e9r\u00e9brales associ\u00e9s \u00e0 d'autres malformations.","volume":"51","author":"Bergouignan","year":"1951"},{"key":"b2","series-title":"Hum Pathol","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/S0046-8177(74)80021-3","article-title":"The neurocristopathies. 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