{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:12:40Z","timestamp":1760955160417},"reference-count":145,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1984,8]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Neurotropic viruses cause a number of important infectious syndromes including encephalitis, myelitis, meningitis, and radiculopathy. In this review, the biology of conventional and unconventional viruses is examined. The host immune response to viruses is discussed, and patterns of viral pathogenesis are explained. The clinical features, laboratory findings, management of important viral infections, such as herpes simplex encephalitis and epidemic encephalitis, are presented. Post-infection syndromes, such as the Guillain-Barr\u00e9 syndrome, and chronic viral infections, such as those causing progressive multifocal leukoencephalopathy and subacute sclerosing panencephalitis, are discussed. Current knowledge concerning the nature of unconventional virus-like agents of the spongiform encephalopathies, including kuru and Creutzfeldt-Jakob disease, is summarized. Finally, viral infections of immunocompromised patients and the possible role of viruses in the newly described acquired immunodeficiency syndrome (AIDS) are examined.<\/jats:p>","DOI":"10.3171\/jns.1984.61.2.0207","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T16:21:56Z","timestamp":1241799716000},"page":"207-224","source":"Crossref","is-referenced-by-count":37,"title":["Viral infections of the nervous system"],"prefix":"10.3171","volume":"61","author":[{"given":"Leslie P.","family":"Weiner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John O.","family":"Fleming","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Postgrad Med J","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1136\/pgmj.49.572.393","article-title":"Herpes simplex encephalitis: a clinical and pathological analysis of twenty-two cases.","volume":"49","author":"Adams","year":"1973"},{"key":"b2","series-title":"Infect Immun","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1128\/iai.21.2.442-447.1978","article-title":"Possible role of Fc receptors on cells infected and transformed by herpesvirus: escape from immune cytolysis.","volume":"21","author":"Adler","year":"1978"},{"key":"b3","series-title":"Recent Advances in Clinical Virology.","first-page":"21","article-title":"Subacute sclerosing panencephalitis","volume":"1","author":"Agnarsd\u00f3ttir","year":"1977"},{"key":"b4","series-title":"Psychoneuroimmunology.","first-page":"355","article-title":"Hormonal influences on immunologic and related phenomena","author":"Ahlquist","year":"1981"},{"key":"b5","series-title":"J Exp Med","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1084\/jem.117.6.879","article-title":"Activation of lysosomal enzymes in virus-infected cells and its possible relationship to cytopathic effects.","volume":"117","author":"Allison","year":"1963"},{"key":"b6","series-title":"Adv Immunol","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/S0065-2776(08)60835-4","article-title":"The biology of monoclonal lymphokines secreted by T cell lines and hybridomas.","volume":"33","author":"Altman","year":"1982"},{"key":"b7","series-title":"Adv Hum Genet","first-page":"137","article-title":"HLA \u2014 a central immunological agency of man.","volume":"10","author":"Amos","year":"1980"},{"key":"b8","series-title":"Prog Med Virol","first-page":"40","article-title":"Structural and functional alterations in cultured cells infected with cytocidal viruses.","volume":"19","author":"Bablanian","year":"1975"},{"key":"b9","series-title":"Bacteriol Rev","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1128\/br.35.3.235-241.1971","article-title":"Expression of animal virus genomes.","volume":"35","author":"Baltimore","year":"1971"},{"key":"b10","series-title":"Prog Med Virol","first-page":"1","article-title":"Herpes simplex virus infection of nervous tissue in animals and man.","volume":"20","author":"Baringer","year":"1975"},{"key":"b11","series-title":"Ann Neurol","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1002\/ana.410040303","article-title":"Experimental scrapie in mice: ultrastructural observations.","volume":"4","author":"Baringer","year":"1978"},{"key":"b12","series-title":"J Virol","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1128\/jvi.32.3.779-789.1979","article-title":"Membrane proteins specified by herpes simplex viruses. 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