{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:37:04Z","timestamp":1715553424003},"reference-count":21,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1984,11]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Experimental delayed cerebral vasospasm was produced in the canine basilar artery by intracisternal injections of blood 2 days apart. The spastic basilar artery was exposed via the transclival route under a surgical microscope, and was dilated by topical application of chlorpromazine, a calmodulin antagonist. Dilatation was dose-dependent, with a median effective dose of 37 \u00b1 16 <jats:italic>\u00b5<\/jats:italic>M. In addition, 100 <jats:italic>\u00b5<\/jats:italic>M chlorpromazine was inserted into the cisterna magna until the intracranial pressure (ICP) reached 200 mm H<jats:sub>2<\/jats:sub>O for 30 minutes, inducing a complete reversal of angiographic delayed cerebral vasospasm in two of five animals. In other studies, the intracisternal perfusion of 100 <jats:italic>\u00b5<\/jats:italic>M chlorpromazine at 1.48 ml\/min for 30 minutes with an ICP of less than 200 mm H<jats:sub>2<\/jats:sub>O induced no serious abnormalities in mean arterial blood pressure and pulse rate of normal animals. Electroencephalography during the intracisternal perfusion of chlorpromazine showed a slight to moderate increase in occurrence of theta waves. No neurological deficits or significant histological abnormalities ascribable to intracisternal chlorpromazine were found.<\/jats:p>","DOI":"10.3171\/jns.1984.61.5.0857","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T16:20:37Z","timestamp":1241799637000},"page":"857-863","source":"Crossref","is-referenced-by-count":16,"title":["Effects of chlorpromazine on experimental delayed cerebral vasospasm"],"prefix":"10.3171","volume":"61","author":[{"given":"Masaru","family":"Nakano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiichi","family":"Tani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toyokazu","family":"Fukumori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Yokota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Surg Neurol","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/0090-3019(82)90118-5","article-title":"Experimental cerebral vasospasm: resolution by chlorpromazine.","volume":"17","author":"Blaumanis","year":"1982"},{"key":"b2","series-title":"Biochemistry","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1021\/bi00595a010","article-title":"Modulator protein as a component of the myosin light chain kinase from chicken gizzard.","volume":"17","author":"Dabrowska","year":"1978"},{"key":"b3","series-title":"Mol Pharmacol","first-page":"66","article-title":"Calcium-regulated modulator protein interacting agents inhibit smooth muscle calcium-stimulated protein kinase and ATPase.","volume":"17","author":"Hidaka","year":"1980"},{"key":"b4","series-title":"Mol Pharmacol","first-page":"49","article-title":"Selective inhibitors of Ca2+-binding modulator of phosphodiesterase produce vascular relaxation and inhibit actin-myosin interaction.","volume":"15","author":"Hidaka","year":"1979"},{"key":"b5","series-title":"Electroencephalogr Clin Neurophysiol","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/0013-4694(58)90040-3","article-title":"The effect of orally administered chlorpromazine on the electroencephalogram of man.","volume":"10","author":"J\u00f6rgensen","year":"1958"},{"key":"b6","series-title":"J Pharmacol Exp Ther","first-page":"494","article-title":"Effects of N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide and other calmodulin antagonists (calmodulin interacting agents) on calcium-induced contraction of rabbit aortic strips.","volume":"217","author":"Kanamori","year":"1981"},{"key":"b7","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"90","DOI":"10.3171\/jns.1960.17.1.0090","article-title":"Local spasm in cerebral arteries.","volume":"17","author":"Lende","year":"1960"},{"key":"b8","series-title":"Mol Pharmacol","first-page":"690","article-title":"Binding of trifluoperazine to the calcium-dependent activator of cyclic nucleotide phosphodiesterase.","volume":"13","author":"Levin","year":"1977"},{"key":"b9","series-title":"Mol Pharmacol","first-page":"581","article-title":"Mechanism by which psychotropic drugs inhibit adenosine cyclic 3\u2032,5\u2032-monophosphate phosphodiesterase of brain.","volume":"12","author":"Levin","year":"1976"},{"key":"b10","series-title":"J Pharmacol Exp Ther","first-page":"454","article-title":"Selective binding of antipsychotics and other psychoactive agents to the calcium-dependent activator of cyclic nucleotide phosphodiesterase.","volume":"208","author":"Levin","year":"1979"},{"key":"b11","series-title":"J Biol Chem","doi-asserted-by":"publisher","first-page":"8378","DOI":"10.1016\/S0021-9258(18)43501-6","article-title":"Inhibitory action of chlorpromazine, dibucaine, and other phospholipid-interacting drugs on calcium-activated, phospholipid dependent protein kinase.","volume":"255","author":"Mori","year":"1980"},{"key":"b12","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"94","DOI":"10.3171\/jns.1963.20.2.0094","article-title":"Prevention of serotonin-produced cerebral vasospasm. 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Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters.","volume":"143","author":"van Rossum","year":"1963"},{"key":"b20","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3171\/jns.1983.58.1.0011","article-title":"Delayed cerebral vasospasm is not reversible by aminophylline, nifedipine, or papaverine in a \u201ctwo-hemorrhage\u201d canine model.","volume":"58","author":"Varsos","year":"1983"},{"key":"b21","series-title":"Adv Cyclic Nucleotide Res","first-page":"285","article-title":"Mechanism for selectively inhibiting the activation of cyclic nucleotide phosphodiesterase and adenylate cyclase by antipsychotic agents.","volume":"9","author":"Weiss","year":"1978"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/61\/5\/article-p857.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/61\/5\/article-p857.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/61\/5\/article-p857.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,24]],"date-time":"2022-07-24T18:18:45Z","timestamp":1658686725000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/61\/5\/article-p857.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,11]]},"references-count":21,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.3171\/jns.1984.61.5.0857","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[1984,11]]}}}